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Journals / The Turkish Journal of Ear Nose and Throat / 2019 / Cilt: 29 - Sayı: 2

May zonula occludens proteins regulate the pathogenesis of allergic rhinitis?

Sevinç İNAN
Esra TOPRAK KANIK
Ahmet TÜRKELİ
Ercan PINAR
Hasan YÜKSEL
Özge YILMAZ
Elgin TÜRKÖZ ULUER
Pages
100–106
Publication Date
2022-10-19
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Occludin, claudin-1, and JAM scores were significantly lower in the mucosal samples fromatopic patients, compared to the non-atopic patients (median 142.5 vs. 288, 153 vs. 296, and 156 vs. 312, respectively; p

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: This study aims to investigate the expression pattern of zonula occludens (ZO) proteins, namely occludin, claudin-1,tricellulin, junctional adhesion molecules (JAM), and ZO-1, -2, and -3 in nasal mucosal biopsies of individuals with and without allergicsensitization.Patients and Methods: Between August 2011 and August 2012, a total of 69 patients (38 males, 31 females; mean age 28.0 years,range, 18 to 61 years) who underwent surgery for nasal septum deviation were included in this cross-sectional study.
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Key Findings & Data:These samples were stained immunohistochemically for occludin, claudin-1, tricellulin, JAM, and ZOs.
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Conclusion & Impact:Occludin, claudin-1, and JAM scores were significantly lower in the mucosal samples fromatopic patients, compared to the non-atopic patients (median 142.5 vs. 288, 153 vs. 296, and 156 vs. 312, respectively; p
🔬Design:Research Article
📍Scope:2011 Verileri
⚙️Variables:Domain Parameters

Abstract

Objectives: This study aims to investigate the expression pattern of zonula occludens (ZO) proteins, namely occludin, claudin-1,tricellulin, junctional adhesion molecules (JAM), and ZO-1, -2, and -3 in nasal mucosal biopsies of individuals with and without allergicsensitization.Patients and Methods: Between August 2011 and August 2012, a total of 69 patients (38 males, 31 females; mean age 28.0 years,range, 18 to 61 years) who underwent surgery for nasal septum deviation were included in this cross-sectional study. All patientsunderwent skin prick test with environmental allergen mixtures. Cup forceps biopsy samples were obtained from the inferior turbinateduring septoplasty. These samples were stained immunohistochemically for occludin, claudin-1, tricellulin, JAM, and ZOs. Stainingintensity was graded semi-quantitatively using the H-Score.Results: Of all patients, 14 were atopic. Occludin, claudin-1, and JAM scores were significantly lower in the mucosal samples fromatopic patients, compared to the non-atopic patients (median 142.5 vs. 288, 153 vs. 296, and 156 vs. 312, respectively; p

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Cite This Article

İNAN, S., KANIK, E. T., TÜRKELİ, A., PINAR, E., YÜKSEL, H., YILMAZ, Ö., ULUER, E. T. (2022). May zonula occludens proteins regulate the pathogenesis of allergic rhinitis?. The Turkish Journal of Ear Nose and Throat, Cilt: 29 - Sayı: 2, 100–106. https://ajindex.com/articles/597938

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