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Journals / The European Research Journal / 2015 / Cilt: 1 - Sayı: 3

Relationship between fibroblast growth factor and arrhythmogenesis in normotensive patients with polycystic kidney disease

Fahriye VATANSEVER
Erhan TENEKECİOGLU
Kemal KARAAGAC
Osman Can YONTAR
Mehmet DEMİR
Abdulmecit YİLDİZ
Pages
106–112
Publication Date
2022-10-18
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In the correlation analyzes, FGF-23 was significantly correlated with Tp-e, Tp-e/QT and Tp-e/QTc (r=0.388, p=0.003; r=0.472, p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Autosomal dominant polycystic kidney disease (ADPKD) is the most common life-threatening genetic disease.
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Key Findings & Data:Recent prospective studies showed a powerful and dose dependent association between increasing FGF-23 levels and greater risk of mortality among chronic kidney disease patients.
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Conclusion & Impact:In the correlation analyzes, FGF-23 was significantly correlated with Tp-e, Tp-e/QT and Tp-e/QTc (r=0.388, p=0.003; r=0.472, p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives. Autosomal dominant polycystic kidney disease (ADPKD) is the most common life-threatening genetic disease. Recent prospective studies showed a powerful and dose dependent association between increasing FGF-23 levels and greater risk of mortality among chronic kidney disease patients. In this study, our aim is to evaluate electrocardiogram derived arrhythmogenesis markers such as Tp-e, Tp-e/QT and Tpe/QTc ratio ADPKD. Methods. Data of 31 patients with ADPKD and age-sex matched 26 healthy were gained for study. Electrocardiogram and echocardiogram measurements, various serum markers were compared between groups. Results. FGF-23 was significantly higher, and eGFR was significantly lower in the ADPKD patients. Myocardial thickness was also higher in ADPKD group. Corrected QT dispersion, Tpe, Tp-e/QT and Tp-e/QTc were also compared between groups. All indicators were significantly worse in ADPKD group. In the correlation analyzes, FGF-23 was significantly correlated with Tp-e, Tp-e/QT and Tp-e/QTc (r=0.388, p=0.003; r=0.472, p

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Cite This Article

VATANSEVER, F., TENEKECİOGLU, E., KARAAGAC, K., YONTAR, O. C., DEMİR, M., YİLDİZ, A. (2022). Relationship between fibroblast growth factor and arrhythmogenesis in normotensive patients with polycystic kidney disease. The European Research Journal, Cilt: 1 - Sayı: 3, 106–112. https://ajindex.com/articles/597824

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