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Journals / The European Research Journal / 2018 / Cilt: 4 - Sayı: 1

Gender dysphoria in an adolescent diagnosed with Klinefelter syndrome over a follow-up period

Ozden Sukran UNERİ
Zeynep GOKER
Gulser DİNC
Sabide Duygu TUNAS
Pages
48–51
Publication Date
2022-10-18
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Further studies, which are randomized-controlled ones, can help to better understand the subject

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Although genetic factors have been thought to be main cause for gender dysphoria, its etiology is still notclearly understood.
📊
Key Findings & Data:Herein, we report a 16year-old adolescent patient displaying gender dysphoria features, who has revealed Klinefelter syndrome aftergenetic examination, and has been treated with testosterone hormone, and his gender dysphoria symptomshave disappeared.
💡
Conclusion & Impact:Further studies, which are randomized-controlled ones, can help to better understand the subject
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Although genetic factors have been thought to be main cause for gender dysphoria, its etiology is still notclearly understood. Klinefelter syndrome is the most seen sex chromosomal disorder. In the literature, thereare fewer case reports in connection with Klinefelter syndrome and gender dysphoria. Herein, we report a 16year-old adolescent patient displaying gender dysphoria features, who has revealed Klinefelter syndrome aftergenetic examination, and has been treated with testosterone hormone, and his gender dysphoria symptomshave disappeared. In our case, chromosomal anomaly and lower levels of androgen could play a role in theetiopathogenesis of gender dysphoria. Bringing Klinefelter syndrome disorder to mind in gender dysphoriacases, even it is a rare disorder, could positively affect the course of the treatment as was in our case. Therelation between psychiatric symptoms, which can be seen in gender dysphoria, and testosterone is not knownexactly. Further studies, which are randomized-controlled ones, can help to better understand the subject

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Cite This Article

UNERİ, O. S., GOKER, Z., DİNC, G., TUNAS, S. D. (2022). Gender dysphoria in an adolescent diagnosed with Klinefelter syndrome over a follow-up period. The European Research Journal, Cilt: 4 - Sayı: 1, 48–51. https://ajindex.com/articles/597661

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References (16)

  1. Smith ES, Junger J, Derntl B, Habel U. The transsexual brain--A review of findings on the neural basis of transsexualism. Neurosci Biobehav Rev 2015;59:251-66
  2. Heylens G, De Cuypere G, Zucker KJ, Schelfaut C, Elaut E, Vanden Bossche H, et al. Gender identity disorder in twins: a review of the case report literature. J Sex Med 2012;9:751-7
  3. Green R. Family cooccurrence of ‘‘gender dysphoria’’: ten sibling or parent-child pairs. Arch Sex Behav 2000;29:499-507
  4. Haberman M, Hollingsworth F, Falek A, Michael RP. Gender identity confusion, schizophrenia and a 47 XYY karyotype: a case report. Psychoneuroendocrinology 1975;1:207-9
  5. Buhrich N, Barr R, Lam-Po-Tang PR. Two transsexuals with 47,XYY karyotype. Br J Psychiatry 1978;133:77-81
  6. Snaith RP, Penhale S, Horsfield P. Male-to-female transsexual with XYY karyotype. Lancet 1991;337:557-8
  7. Taneja N, Ammini AC, Mohapatra I, Saxena S, Kucheria K. A transsexual male with 47, XYY karyotype. Br J Psychiatry 1992;161:698-9
  8. Turan MT, Esel E, Dundar M, Candemir Z, Basturk M, Sofuoglu S, et al. Female-to-male transsexual with 47, XXX karyotype. Biol Psychiatry 2000;48:1116-7
  9. Mepham N, Bouman WP, Arcelus J, Hayter M, Wylie KR. People with gender dysphoria who self-prescribe cross-sex hormones: prevalence, sources, and side effects knowledge. J Sex Med 2014;11:2995-3001
  10. Khandelwal A, Agarwal A, Jiloha RC. A 47-XXY female with gender identity disorder. Arch Sex Behav 2010;39:1021-3
  11. Fisher AD, Castellini G, Casale H, Fanni E, Bandini E, Campone B, et al. Hypersexuality, paraphilic behaviors, and gender dysphoria in individuals with Klinefelter's syndrome. J Sex Med 2015;12:2413-24
  12. Kawahara K, Jono T, Nishi Y, Ushijima H, Ikeda M. Effects of testosterone therapy on bipolar disorder with Klinefelter syndrome. Gen Hosp Psychiatry 2015;37:192e1-e2
  13. American Psychiatric Association. Diagnostic and statistical manual of mental disorders (DSM-5). American Psychiatric Pub, 2013
  14. Bao AM, Swaab DF. Sexual differentiation of the human brain: relation to gender identity, sexual orientation and neuropsychiatric disorders. Front Neuroendocrinol 2011;32:214-26
  15. Lanfranco F, Kamischke A, Zitzmann M, Nieschlag E. Klinefelter's syndrome. Lancet 2004;364:273-83
  16. Kovacs D, Vassos E, Liu X, Sun X, Hu J, Breen G, et al. The androgen receptor gene polyglycine repeat polymorphism is associated with memory performance in healthy Chinese individuals. Psychoneuroendocrinology 20