SavedAdd your journal

Journals / The European Research Journal / 2021 / Cilt: 7 - Sayı: 2

Comparison of the effects of isoflurane and sevoflurane on surgical stress in intracranial tumor surgery

Vuslat Muslu Erdem
Halil Erkan Sayan
Şefika Gülsen Korfalı
Pages
142–151
Publication Date
2022-10-18
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusions: Using isoflurane or sevoflurane for anesthesia during intracranial tumor surgery are not superior to each other regarding hemodynamic and hormonal stress response.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objectives: Surgeries can trigger stress responses including metabolic and hormonal changes.
📊
Key Findings & Data:Anesthesia was induced with sodium thiopental fentanyl and vecuronium bromide and maintained with a 50% oxygen-air mixture along with isoflurane or sevoflurane.
💡
Conclusion & Impact:Conclusions: Using isoflurane or sevoflurane for anesthesia during intracranial tumor surgery are not superior to each other regarding hemodynamic and hormonal stress response.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:surgical stress · isoflurane · sevoflurane

Abstract

Objectives: Surgeries can trigger stress responses including metabolic and hormonal changes. It is important to suppress stress response during surgery. We compared the effects of isoflurane and sevoflurane on surgical stress in intracranial tumor surgery. Methods: Thirty ASA physical status I, II, III patients, scheduled for elective craniotomies, were enrolled in this prospective, randomized study. Anesthesia was induced with sodium thiopental fentanyl and vecuronium bromide and maintained with a 50% oxygen-air mixture along with isoflurane or sevoflurane. Venous blood was sampled to measure cortisol, ACTH and prolactin levels 24 hours before surgery, 1 min before anesthesia induction, during tumor removal, 1 min after extubation, at 3, 6, 12, 24, 48 hours. Results: There was no statistically significant difference between two groups regarding demographic characteristics of patients. In group I, ACTH levels were significantly higher 1 min after extubation, at 3 and 6 hours. In Group S, significant increases were observed during tumor removal, 1 min after extubation, at 3 and 6 hours. Cortisol levels were significantly higher in both group after tumor removal, 1 min after extubation, at 3, 6, 12 and 24 hours. Prolactin levels were significantly higher in Group I during tumor removal, after extubation, at 3 and 6 hours. In group S, significant increase in prolactin level was observed only during tumor removal and 1 min after extubation. There were no significant differences in ACTH, cortisol and prolactin values between the two groups. Conclusions: Using isoflurane or sevoflurane for anesthesia during intracranial tumor surgery are not superior to each other regarding hemodynamic and hormonal stress response.

🔖

Cite This Article

Erdem, V. M., Sayan, H. E., Korfalı, Ş. G. (2022). Comparison of the effects of isoflurane and sevoflurane on surgical stress in intracranial tumor surgery. The European Research Journal, Cilt: 7 - Sayı: 2, 142–151. https://ajindex.com/articles/597404

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (18)

  1. Breslow MJ. Clinical Implications of the stress response to surgery. In: Rogers, MC., Tinker, JH., Covino, BG., Longnecker D, ed. Principles and Practice of Anesthesiology. 2nd. Mosby; 1998:103-120
  2. Chi OZ, Choi YK, Lee DI, Kim YS, Lee I. Intraoperative mild hypothermia does not increase the plasma concentration of stress hormones during neurosurgery. Can J Anaesth 2001;48:815-8
  3. Galley HF, DiMatteo MA, Webster NR. Immunomodulation by anaesthetic, sedative and analgesic agents: does it matter? Intensive Care Med 2000;26:267-74
  4. Torri G. Inhalation anesthetics: a review. Minerva Anestesiol 2010;76:215-28
  5. Milde LN. Cerebral protection. In: Cucchiara RF, Black S, Mchenfelder JD (eds.). Clinical Neuroanesthesia. New York: Churchill Livingstone, 1998: pp.177-228
  6. Yörükoğlu D. Tümör cerrahisinde anestezi. In: Kecik Y, ed. Nöroanestezi
  7. Baskı. Ankara: Atlas Yayıncılık; 2000:171-198
  8. Kehlet H. The surgical stress response: should it be prevented? Can J Surg 1991;34:565-7
  9. Chrousos GP. The role of stress and the hypothalamic–pituitary–adrenal axis in the pathogenesis of the metabolic syndrome: neuro-endocrine and target tissue-related causes. Int J Obes 2000;24:S50-5
  10. Aono H, Takeda A, Tarver SD, Goto H. Stress responses in three different anesthetic techniques for carbon dioxide laparoscopic cholecystectomy. J Clin Anesth 1998;10:546-50
  11. Desborough JP. The stress response to trauma and surgery. Br J Anaesth 2000;85:109-17
  12. Besnier E, Clavier T, Compere V. The hypothalamic-pituitary-adrenal axis and anesthetics: a review. Anesth Analg. 2017;124:1181-9
  13. Marana E, Annetta MG, Meo F, Parpaglioni R, Galeone M, Maussier ML, et al. Sevoflurane improves the neuroendocrine stress response during laparoscopic pelvic surgery. Can J Anesth 2003;50:348-54
  14. Naito Y, Tamai S, Shingu K, Shindo K, Matsui T, Segawa H, et al. Responses of plasma adrenocorticotropic hormone, cortisol, and cytokines during and after upper abdominal surgery. Anesthesiology 1992;77:426-31
  15. Liu S, Carpenter RL, Neal JM. Epidural anesthesia and analgesia: their role in postoperative outcome. Anesthesiology 1995;82:1474-506
  16. Weissman C. The metabolic response to stress: an overview and update. Anesthesiology 1990;73:308-27
  17. Geze S, Yilmaz AA, Tuzuner F. The effect of scalp block and local infiltration on the haemodynamic and stress response to skull-pin placement for craniotomy. Eur J Anaesthesiol 2009;26:298-303
  18. Kendrišić M, Šurbatović M, Djo