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Journals / The European Research Journal / 2022 / Cilt: 8 - Sayı: 3

Protective effect of Tulbaghia violacea extract on cardiac damage: deep circulatory arrest rat model

Fatih GÜNGÖREN
Bişar AMAÇ
Mehmet Salih AYDIN
Nazım KANKILIÇ
Yusuf ÇAKMAK
Muhammet Emin GÜLDÜR
İsmail KOYUNCU
Emine Zeynep TARİNİ
Mesut ENGİN
Şenol YAVUZ
Pages
396–403
Publication Date
2022-10-18
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusions: As a result of our study, we revealed that T. violacea extract has a protective effect on organ and tissue damage in the TCA model.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: Total circulatory arrest (TCA) technique is a method used in cardiac surgery accompanied by cardiopulmonary bypass (CPB).
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Key Findings & Data:It has been shown that Tulbaghia violacea extract increases antioxidant capacity, regulates blood pressure, decreases lipid peroxide, and reduces atherosclerosis.
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Conclusion & Impact:Conclusions: As a result of our study, we revealed that T. violacea extract has a protective effect on organ and tissue damage in the TCA model.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Circulation · arrest · protective agent

Abstract

Objectives: Total circulatory arrest (TCA) technique is a method used in cardiac surgery accompanied by cardiopulmonary bypass (CPB). It has been shown that Tulbaghia violacea extract increases antioxidant capacity, regulates blood pressure, decreases lipid peroxide, and reduces atherosclerosis. In this experimental study, we aimed to investigate the effect of T. violacea extract administration on serum oxidative stress parameters (Total antioxidant status [TAS], total oxidant status [TOS] and oxidative stress index [OSI] and deoxyribonucleic acid [DNA] damage level with 8-Hydroxy-2-Deoxyguanosine [8-OHdG]) and histopathological changes in the heart and other organs in rats with deep circulatory arrest model. Methods: In this study, 48 Wistar Albino adult rats, 24 female and 24 male, obtained from Harran University Experimental Animals Research Center were used. The average weight of female rats was 250-300 g, and the average weight of male rats was 450-500 g. These rats were randomly divided into four groups. 6 male and 6 female rats were used in each group (Group 1 = Sham, Group 2 = Injury, Group 3 = Treatment and Injury, Group 4 = Treatment). Results: As a result of this experimental study, the changes in the biochemical 8-OHdG, TOS, OSI and TAS levels of the groups were found to be statistically significant (p < 0.001). In the subgroup analyzes of the data, 8-OHdG level, which is an oxidative DNA damage marker in Group 2 was higher than the Group 1, Group 3 and Group 4 and there was a statistically significant difference (p < 0.001, p = 0.027 and p < 0.001; respectively). The TOS level of the injury group was higher than Group 1, Group 3 and Group 4 and there was a statistically significant difference (p < 0.001, p = 0.003 and p < 0.001; respectively). Conclusions: As a result of our study, we revealed that T. violacea extract has a protective effect on organ and tissue damage in the TCA model.

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Cite This Article

GÜNGÖREN, F., AMAÇ, B., AYDIN, M. S., KANKILIÇ, N., ÇAKMAK, Y., GÜLDÜR, M. E., KOYUNCU, İ., TARİNİ, E. Z., ENGİN, M., YAVUZ, Ş. (2022). Protective effect of Tulbaghia violacea extract on cardiac damage: deep circulatory arrest rat model. The European Research Journal, Cilt: 8 - Sayı: 3, 396–403. https://ajindex.com/articles/597371

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