Journals / Selçuk Tıp Dergisi / 2018 / Cilt: 34 - Sayı: 1

A Retrospective Analysis of Oral Mucosa Pathologies: A Single-Center Trial

Oral Mukozal Patolojilere Ait Retrospektif Klinik Çalışma: Tek Merkeze Ait Sonuçlar

Pages
11–17
Publication Date
2022-10-17
DOI
—
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⚡ TL;DR(Too Long; Didn't Read)

A commerciallyavailable statistical package (SPSS17.0) was used for descriptive statistical analysis.Results: The results showed that benign epithelial proliferations and reactive pathologies were the mostfrequently diagnosed lesion, accounting for 22.7% of the total number of patients.

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Objective & Hypothesis:Aim: Oral cancer is the sixth most common cancer worldwide however a wide range of diseases mayaffect the oral mucosa.
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Key Findings & Data:We aim to determine the prevalence of the oral mucosal pathologies in our patientseries and discuss the final diagnosis in relation to sex, age and subsite distribution.Patients and Methods: This was a cross sectional descriptive study, including 288 patients with oralmucosal pathologies, diagnosed at Baskent University Konya Hospital between January 2002 andDecember 2014.
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Conclusion & Impact:A commerciallyavailable statistical package (SPSS17.0) was used for descriptive statistical analysis.Results: The results showed that benign epithelial proliferations and reactive pathologies were the mostfrequently diagnosed lesion, accounting for 22.7% of the total number of patients.
🔬Design:Research Article
📍Scope:2002 Verileri
⚙️Variables:Domain Parameters

Abstract

Aim: Oral cancer is the sixth most common cancer worldwide however a wide range of diseases mayaffect the oral mucosa. We aim to determine the prevalence of the oral mucosal pathologies in our patientseries and discuss the final diagnosis in relation to sex, age and subsite distribution.Patients and Methods: This was a cross sectional descriptive study, including 288 patients with oralmucosal pathologies, diagnosed at Baskent University Konya Hospital between January 2002 andDecember 2014. Data were retrieved from archives of pathology laboratory, retrospectively. A commerciallyavailable statistical package (SPSS17.0) was used for descriptive statistical analysis.Results: The results showed that benign epithelial proliferations and reactive pathologies were the mostfrequently diagnosed lesion, accounting for 22.7% of the total number of patients. Among this reactivepathologies, squamous papillomas were the most common (n: 31; 9,9%), followed by fibroepithelial polyps(n:24;7,7%) and irritation fibromas (n:16; 5,1%). Oral mucosal dermatoses were the second commonbenign lesions, accounting for 21,8% (n:63) of all cases. Of the 288 oral mucosal pathologies 15,3%(n:44) were malignant and 17,7% (n:51) were precancerous. Squamous cell carcinoma were comprised of95,5% of all the malignant lesions. Premalignant lesions were with the following distribution: squamouscell hyperplasia (n:47; 16% ), moderate dysplasia (n:2; 0,7% ) and lichenoid dysplasia (n:2; 0,7% ). Lipwas the most frequently involved site for squamous cell carcinoma. The male to female ratio was almostequal in both sex for premalignant lesions however there was slight male predominance for squamouscell carcinoma (p>0.1). Squamous cell carcinoma was commonly seen in the older age group comparedto benign and precancerous lesions.Conclusion: The similar clinical appearance of oral mucosal pathologies in a very wide spectrum isa compelling element for clinicians in the process of diagnosis. Especially in malignant lesions earlydiagnosis may be life saving. Therefore, it is important to reveal our own series about these pathologies.This study, by demonstrating distribution of histopathologically classified lesions according to someclinical features such as location, age and gender, will guide and facilitate the clinical diagnosis.

Özet

Amaç: Oral skuamöz hücreli karsinom dünyada en sık görülen 6. tümör olarak karsımıza çıkmaktadır. Bununla birlikte pek çok hastalık oral mukozada lezyon olusturabilmektedir. Bu çalısmada 10 yıllık süreçte kendi hasta serimize ait oral mukoza patolojierini olusturan lezyonlar histopatolojik tanılara göre sınıflandırılmıs ve tanılara göre lezyonların yeri, yas ve cinsiyet dagılımları tespit edilmis ve malignite ile iliskileri belirlenmeye çalısılmıstır. Hastalar ve Yöntem: Çalısmamız 2002-2014 yılları arasında Baskent Üniversitesi, Tıp Fakültesi Konya Uygulama ve Arastırma hastanesi kulak burun bogaz hastalıkları bölümü tarafından tanı amacıyla biopsi alınarak patoloji laboratuarına gönderilen 288 hastaya ait oral mukoza lezyonunun retrospektif analizini içermektedir. Hastalara ait histopatolojik tanı, yas, cinsiyet ve lokalizasyon bilgisi patoloji rapor arsivinden elde edilmistir. Istatistiksel tanımlayıcı analiz SPSS17.0 programı ile yapılmıstır. Bulgular: Olguların büyük çogunlugunu benign epitelyal proliferasyon ve reaktif patolojiler olusturmaktadır(%22,7). Bu grupta en sık skuamöz papillom(n: 31; % 9,9) görülmüs olup bunu fibroepitelyal polip (n:24; %7,7) ve irritasyon fibromu (n:16; %5,1) izlemektedir. Benign patolojiler içerisinde oral mukozal dermatozlar en sık görülen ikinci lezyondur (n:63, % 21,8). Çalısmamızda 288 oral mukozal lezyonun % 15,3’ünü (n:44) malign patolojiler ve % 17,7’sini (n:51) prekanseröz lezyonlar olustumaktadır. Skuamöz hücreli karsinom tüm malign patolojilerin %95,5’idir.Tespit edilen premalign lezyonlar; skuamöz hücreli hiperplazi (n:47; 16%), orta dereceli displazi (n:2; % 0,7) ve likenoid displazidir (n:2; % 0,7). Skuamöz hücreli karsinom en sık dudakta lokalizedir. Kadın erkek oranı premalign lezyonlar için hemen hemen esit olup skuamöz hücreli karsinom erkeklerde biraz daha fazladır (p>0.1). Sonuç: Skuamöz hücreli karsinom, benign lezyonlar ve premalign lezyonlara göre daha yaslı hastalarda görülmektedir. Çok genis spektrumdaki birçok oral mukozal patolojinin benzer bir klinik görüntüsü olması klinisyenleri tanı asamasında zorlayıcı bir unsurdur. Özellikle malign lezyonlarda erken teshis hayat kurtarıcı olabilir. Bu nedenle patolojilere yönelik kendi serilerimizi olusturmak önemlidir. Histopatolojik tanılarına göre sınıflandırılmıs lezyonların lokalizasyon, yas ve cinsiyet gibi bazı klinik özelliklerine göre dagılımını veren bu serimiz klinik tanıda yol gösterici ve kolaylastırıcı olacaktır.

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Cite This Article

TOPAL, O., ERİNANC, H. (2022). A Retrospective Analysis of Oral Mucosa Pathologies: A Single-Center Trial. Selçuk Tıp Dergisi, Cilt: 34 - Sayı: 1, 11–17. https://ajindex.com/articles/591877

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