Journals / Selçuk Tıp Dergisi / 2019 / Cilt: 35 - Sayı: 3

The Role of Papanicolaou Test in the Diagnosis of Endometrial Carcinoma

Endometrial Karsinom Tanısında Papanicolaou Testinin Rolü

Pages
176–179
Publication Date
2022-10-17
DOI
—
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⚡ TL;DR(Too Long; Didn't Read)

The rate of the atypical endometrial cells encountered by Pap smears has increased as grade of the tumors increased.Conclusion: We have concluded that the detection rate of atypical cells by Pap smear in endometrial carcinomas is considerably high.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: Pap smear test is a commonly used and effective screening method in detection of cervical cancer and its precursor lesions.
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Key Findings & Data:We have aimed to investigate the incidence rate of atypical endometrial cells in Pap smears of the patients diagnosed with endometrial carcinoma and the correlation between these cells and clinicopathological parameters.Patients and Methods: In this study, patients who were diagnosed with endometrial carcinoma and who had smear sampling between January 2015 and September 2017 were examined retrospectively.
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Conclusion & Impact:The rate of the atypical endometrial cells encountered by Pap smears has increased as grade of the tumors increased.Conclusion: We have concluded that the detection rate of atypical cells by Pap smear in endometrial carcinomas is considerably high.
🔬Design:Research Article
📍Scope:2015 Verileri
⚙️Variables:Domain Parameters

Abstract

Aim: Pap smear test is a commonly used and effective screening method in detection of cervical cancer and its precursor lesions. There is a very limited number of studies on use of Pap smears in diagnosis of the endometrial carcinomas. We have aimed to investigate the incidence rate of atypical endometrial cells in Pap smears of the patients diagnosed with endometrial carcinoma and the correlation between these cells and clinicopathological parameters.Patients and Methods: In this study, patients who were diagnosed with endometrial carcinoma and who had smear sampling between January 2015 and September 2017 were examined retrospectively. Histological type, nuclear grade and Pap smear results of endometrial carcinoma cases were evaluated. Results: Pap smear sampling was concurrently performed in 59 of the 97 patients diagnosed with endometrial carcinoma. The ages of the patients who underwent smear sampling ranged between 42 and 82 years (mean 57.43±9.08 years). The menopausal status evaluation of the women revealed that 12 (20.3%) and 47 (79.7%) patients were premenopausal and postmenopausal, respectively. Endometrioid type carcinoma was encountered in 51 (86.4%) patients as the most commonly found histological type. Serous, clear cell and mucinous carcinomas were determined in 6 (10%), 1 (1.8%) and 1 (1.8%) patients, respectively. The results of Pap smear tests were atypical in 24 (40.7%) patients whereas normal results were obtained in 35 (59.3%) patients. Nuclear grade assessment of the carcinomas showed that grade 1, grade 2 and grade 3 carcinomas were discovered in 24 (40.7%), 25 (42.3%) and 10 (17%) patients, respectively. The rate of the atypical endometrial cells encountered by Pap smears has increased as grade of the tumors increased.Conclusion: We have concluded that the detection rate of atypical cells by Pap smear in endometrial carcinomas is considerably high. The incidence of atypical cells is higher in nonendometrioid and high- grade carcinomas.

Özet

Amaç: Pap smear testi, serviks kanseri ve öncü lezyonlarını taramak için en sık kullanılan ve etkili bir tarama yöntemidir. Endometrial karsinomların tanısında Pap smear testinin kullanımı ile ilgili çok az çalışma vardır. Biz bu çalışmada endometrial karsinom tanısı almış hastaların Pap smearlerinde atipik endometrial hücrelerin bulunma oranını ve klinikopatolojik parametrelerle korelasyonunu araştırmayı amaçladık. Hastalar ve Yöntem: Bu çalışmada Ocak 2015-Eylül 2017 yılları arasında endometrial karsinom tanısı konulmuş ve aynı zamanda Pap smear örneklemesi yapılmış hastalar retrospektif olarak incelenmiştir. Endometrial karsinom olgularının histolojik tip, nükleer derece ve Pap smear sonuçları değerlendirilmiştir. Bulgular: Çalışmaya dahil edilen endometrial karsinom tanısı konulmuş 97 hastanın 59’una aynı zamanda smear örneklemesi yapılmıştı. Smear örneklemesi yapılan hastaların yaşları 42-82 yaş aralığındaydı (ortalama57,43±9,08). Hastaların menopoz durumu değerlendirildiğinde 12’si (%20.3) premenopozal ve 47’si (%79.7) postmenopozal durumdaydı. En sık görülen histolojik tip endometrioid olup 51 hastada izlendi (%86.4). 6 hastada seröz (%10), 1 hastada şeffaf hücreli (%1.8) ve 1 hastada müsinöz karsinom (%1.8) mevcuttu. Pap smear sonucu 24 hastada atipik iken (%40.7), 35hastada normaldi (%59.3). Nükleer derece değerlendirildiğinde 24 hastada derece 1 (%40.7), 25 hastada derece 2 (%42.3), 10 hastada derece 3’tü (%17). Tümör derecesi arttıkça Pap smearlerde atipik endometrial hücre görülme oranı artmaktaydı. Sonuç: Endometrial karsinomlarda pap smear de atipik hücre saptama oranlarının azımsanmayacak kadar yüksek olduğu görüldü. Nonendometrioid ve yüksek dereceli karsinomlarda atipik hücre görülme oranları daha fazlaydı.

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Cite This Article

Turan, G., Usta, A. (2022). The Role of Papanicolaou Test in the Diagnosis of Endometrial Carcinoma. Selçuk Tıp Dergisi, Cilt: 35 - Sayı: 3, 176–179. https://ajindex.com/articles/591824

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