Further, compounds 3a, 5, and 6j were also confirmed by X-ray diffraction data.
📌 3 Key Takeaways
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Objective & Hypothesis:A small library of new azomethine derivatives of 3-aryl-2-thioxo-2,3-dihydroquinazolin-4(1 H) -ones was syn- thesized.
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Key Findings & Data:The key intermediates 2-thioxo-quinazolinones (3a e), obtained in 2 steps from the corresponding anilines, were treated with methyl chloroacetate to afford S-substituted esters (4a,d), which were then converted into corre- sponding acetohydrazides (5a,d).
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Conclusion & Impact:Further, compounds 3a, 5, and 6j were also confirmed by X-ray diffraction data.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Abstract
A small library of new azomethine derivatives of 3-aryl-2-thioxo-2,3-dihydroquinazolin-4(1 H) -ones was syn- thesized. The key intermediates 2-thioxo-quinazolinones (3a e), obtained in 2 steps from the corresponding anilines, were treated with methyl chloroacetate to afford S-substituted esters (4a,d), which were then converted into corre- sponding acetohydrazides (5a,d). Further, acetohydrazide (5d) was converted to the azomethines derivatives (6a k) by reacting with a number of suitably substituted benzaldehydes. FTIR,1 H NMR, 13 C NMR, GC-MS, and elemental analyses were used to confirm the assigned structures of the synthesized compounds. Further, compounds 3a, 5, and 6j were also confirmed by X-ray diffraction data.
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Cite This Article
FLORKE, U., SAEED, A., MAHMOOD, S. (2022). Synthesis and characterization of new (E)-N'-(substituted benzylidene)-2-(3-(2- methyl)-4-oxo-3,4-dihydroquinazolin-2-ylthio)acetohydrazides. Turkish Journal of Chemistry, Cilt: 38 - Sayı: 2, 275–287. https://ajindex.com/articles/589478
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