Journals / Respiratory Case Reports / 2022 / Cilt: 11 - Sayı: 2

Coexistence of Sarcoidosis and Silicosis: Case Series

Sarkoidoz ve Silikozis Birlikteliği: Olgu Serisi

Pages
59–64
Publication Date
2022-10-18
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In the light of these cases, it is aimed to draw attention to the usefulness of a wellreceived occupational history in the differential diagnosis and etiology of sarcoidosis and silicosis.

📌 3 Key Takeaways

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Objective & Hypothesis:The differential diagnosis of silicosis includes sarcoidosis, berylliosis, hypersensitivity pneumonia, malignancy, tuberculosis and other granulomatous infections.
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Key Findings & Data:Sarcoidosis is a systemic granulomatous disease with an unknown etiology, although it is thought that occupational exposure to such substances as silica and beryllium may be a trigger.
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Conclusion & Impact:In the light of these cases, it is aimed to draw attention to the usefulness of a wellreceived occupational history in the differential diagnosis and etiology of sarcoidosis and silicosis.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

The differential diagnosis of silicosis includes sarcoidosis, berylliosis, hypersensitivity pneumonia, malignancy, tuberculosis and other granulomatous infections. Sarcoidosis is a systemic granulomatous disease with an unknown etiology, although it is thought that occupational exposure to such substances as silica and beryllium may be a trigger. An incomplete occupational history may lead to a diagnosis of sarcoidosis rather than pneumoconiosis in many cases, although various associations of these two diseases, such as the coexistence and detection of one before or after the other, have been reported in literature. The coexistence of sarcoidosis and silicosis is discussed in the present study with reference to five cases who applied to the Occupational Diseases department of a university hospital. Active pulmonary tuberculosis and lung malignancy were excluded in all cases, and histopathologic examinations of all samples were reported as non-caseating granulomatous inflammation. In the specimen of one case, a birefringent body was identified upon polarized microscopy. In the light of these cases, it is aimed to draw attention to the usefulness of a wellreceived occupational history in the differential diagnosis and etiology of sarcoidosis and silicosis.

Özet

Silikozisin ayırıcı tanısı sarkoidoz, berilyoz, hipersensitivite pnömonisi, malignite, tüberküloz ve diğer granülomatöz enfeksiyonları içerir. Sarkoidoz etiyolojisi tam olarak bilinmeyen sistemik granülomatöz bir hastalıktır ve silika, berilyum gibi mesleki maruziyet faktörlerin tetikleyici ajan olarak rol oynayabileceği düşünülmektedir. Eksik ve dikkatsiz bir meslek öyküsü birçok olguda pnömokonyoz yerine sarkoidoz tanısına yol açabilir. Ek olarak bu iki hastalığın bir arada görülmesine veya bir diğerinin ötekinden önce saptaması gibi durumlara da çeşitli makalelerde dikkat çekilmiştir. Bu yazıda bir üniversite hastanesinin iş ve meslek hastalıkları bölümüne başvuran beş olgu üzerinden sarkoidoz ve silikoz birlikteliği tartışılmıştır. Tüm olgularda aktif akciğer tüberkülozu ve akciğer malignitesi dışlandı. Tüm olguların biyopsi materyallerinin histopatolojik incelemeleri kazeifiye olmayan granülomatöz inflamasyon olarak rapor edildi. Bir olguda polarize mikroskopta ışığı çift kıran cisim gösterildi. Burada, bu olgular ışığında iyi alınmış bir meslek öyküsünün sarkoidoz ve silikozisin ayırıcı tanısı ve etiyolojisini saptamadaki faydasına dikkat çekmek amaçlanmıştır.

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Cite This Article

DEMİRAL, Y., YAVUZ, M. Y. (2022). Coexistence of Sarcoidosis and Silicosis: Case Series. Respiratory Case Reports, Cilt: 11 - Sayı: 2, 59–64. https://ajindex.com/articles/588872

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References (1)

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