Journals / Respiratory Case Reports / 2022 / Cilt: 11 - Sayı: 2

Diffuse Alveolar Hemorrhage Induced by Sevoflurane

Sevofluran ile İndüklenen Diffüz Alveolar Hemoraji

Pages
73–76
Publication Date
2022-10-18
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

None of the predisposing factors or causative reasons for DAH were detected in our case, and so it can be concluded that the use of sevoflurane as an inhaled anesthetic was responsible for the DAH.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:We present here a case of diffuse alveolar hemorrhage (DAH) following exposure to inhaled anesthetic sevoflurane.
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Key Findings & Data:A 29-year-old male was admitted to the plastic surgery department with gynecomastia.
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Conclusion & Impact:None of the predisposing factors or causative reasons for DAH were detected in our case, and so it can be concluded that the use of sevoflurane as an inhaled anesthetic was responsible for the DAH.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

We present here a case of diffuse alveolar hemorrhage (DAH) following exposure to inhaled anesthetic sevoflurane. A 29-year-old male was admitted to the plastic surgery department with gynecomastia. Surgery was performed without complication under general anesthesia with intravenously administered midazolam (4mg), fentanyl and inhaled sevoflurane. Immediate hypoxemia and massive hemorrhage was detected at the end of the operation, and a chest radiography revealed bilateral widespread alveolar infiltrates. The serum hemoglobin level dropped by 2.5 g/dl (from 13 to 10.5 gr) in the postoperative setting. The patient was treated with methylprednisolone (1 gr) administered intravenously daily for 3 days. The hypoxemia resolved and alveolar infiltrates on the chest radiograph disappeared on the 4th day. There is limited data in literature reporting on the association between sevoflurane and DAH. None of the predisposing factors or causative reasons for DAH were detected in our case, and so it can be concluded that the use of sevoflurane as an inhaled anesthetic was responsible for the DAH.

Özet

İnhale anestezik sevoflurana maruz kaldıktan sonra yaygın alveolar hemoraji (DAH) gelişen bir olguyu sunmayı amaçladık. Burada sunulan hasta, jinekomasti nedeniyle plastik cerrahiye başvuran 29 yaşında bir erkek idi. Genel anestezi altında intravenöz midazolam (4mg), fentanil ve inhale sevofluran ile komplikasyonsuz cerrahi uygulandı. Ameliyat sonunda ani hipoksemi ve masif kanama tespit edildi. Akciğer grafisinde bilateral yaygın alveolar infiltratlar görüldü. Ameliyat sonrası dönemde serum hemoglobin düzeyi 2,5 g/dl (13'ten 10,5 gr'a) düştü. Hastaya 3 gün süreyle intravenöz olarak günlük metilprednizolon (1 gr) tedavisi verildi. Dördüncü günde hipoksemi düzeldi ve akciğer grafisinde alveolar infiltratlar kayboldu. Literatürdeki sınırlı veriler, sevofluran ve DAH arasında bir ilişki olduğunu göstermektedir. Bizim olgumuzda DAH' gelişimine neden olan sebepler ve zemin hazırlayan faktörlerin hiçbiri saptanmadı. Bu nedenle, DAH'dan inhale anestezik olarak sevofluran'ın sorumlu olduğu düşünülmektedir.

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Cite This Article

HATTATOĞLU, D. G., KAYA, F. O., YILDIZ, B. P. (2022). Diffuse Alveolar Hemorrhage Induced by Sevoflurane. Respiratory Case Reports, Cilt: 11 - Sayı: 2, 73–76. https://ajindex.com/articles/588857

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References (1)

  1. Lara AR, Schwarz MI. Diffuse alveolar hemorrhage. Chest 2010; 137:1164-71. [CrossRef] 2. Gentz BA, Malan TP Jr. Renal toxicity with sevoflurane: a storm in a teacup? Drugs 2001; 61:2155-62. [CrossRef] 3. Shayevitz JR, Traystman RJ, Adkinson NF, Sciuto AM, Gurtner GH. Inhalation anesthetics augment oxidantinduced pulmonary vasoconstriction: evidence for a membrane effect. Anesthesiology 1985; 63:624-32. [CrossRef] 4. Kim JP, Park JJ, Kim NJ, Woo SH. A case of diffuse alveolar hemorrhage after tonsillectomy -A case report-. Korean J Anesthesiol 2012; 63:165-8. [CrossRef] 5. Austin A, Modi A, Judson MA, Chopra A. Sevoflurane induced diffuse alveolar hemorrhage in a young patient. Respir Med Case Rep 2016; 20:14-5. [CrossRef] 6. Hirakata H, Ushikubi F, Narumiya S, Hatano Y, Nakamura K, Mori K. The effect of inhaled anesthetics on the platelet aggregation and the ligand-binding affinity of the platelet thromboxane A2 receptor. Anesth Analg 1995; 81:114-8. [CrossRef] 7. Doğan IV, Ovali E, Eti Z, Yayci A, Göğüş FY. The in vitro effects of isoflurane, sevoflurane, and propofol on platelet aggregation. Anesth Analg 1999; 88:432-6. [CrossRef] 8. Khanna AK, Cummings KC 3rd. Pulmonary hemorrhage in an outpatient ophthalmic anesthesia setting - it's never "just a cataract". J Anaesthesiol Clin Pharmacol 2012; 28:520-3. [CrossRef] 9. Kim CA, Liu R, Hsia DW. Diffuse alveolar hemorrhage induced by sevoflurane. Ann Am Thorac Soc 2014; 11:853-5. [CrossRef] 10. Murray AW, Smith JD, Ibinson JW. Diffuse alveolar hemorrhage, anesthesia, and cannabis. Ann Am Thorac Soc 201; 11:1338-9. [CrossRef] 11. Mersh R, Ross C. Postoperative diffuse alveolar haemorrhage: insidious negative pressure or sevoflurane induced? BMJ Case Rep 2018; 2018:bcr2017222010. [CrossRef] 12. Hao D, Basnet S, Melnick S, Kim J. Negative pressure pulmonary edema-related diffuse alveolar hemorrhage associated with Sevoflurane and cigarette smoking. J Community Hosp Intern Med Perspect 2019; 9:247-51. [CrossRef] 13. Cengiz O, Kivrak A, Yegen M, Demir M. Sevoflurane induced diffuse alveolar haemorrhage in a young patient after orthopedic surgery: A case report. Niger J Clin Pract 2020; 23:120-2. [CrossRef]