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Journals / Psychiatry and behavioral sciences (Online) / 2019 / Cilt: 9 - Sayı: 3

Intermenstrual Vaginal Bleeding Due to Sertraline Treatment: A Case Report

Erol GOKA
Ömer ASAN
Pages
139–142
Publication Date
2022-10-19
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

We aimed to draw clinician’s attention to this side effect of SSRIs.

📌 3 Key Takeaways

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Objective & Hypothesis:Sertraline and other serotonin reuptake inhibitors are widely used in the treatment of psychiatric disorders such as anxiety disorders and depression.
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Key Findings & Data:SSRIs may increase the risk of bleeding through different mechanisms.
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Conclusion & Impact:We aimed to draw clinician’s attention to this side effect of SSRIs.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Sertraline and other serotonin reuptake inhibitors are widely used in the treatment of psychiatric disorders such as anxiety disorders and depression. Hematological adverse effects related to sertraline are uncommon; most of the reported cases presented with vaginal bleeding, epistaxis, purpura, hematuria, and rectal bleeding. SSRIs may increase the risk of bleeding through different mechanisms. The most emphasized mechanism is lowering platelet aggregation by reducing serotonin reuptake in platelets. This report includes a case of intermenstrual vaginal bleeding due to the use of sertraline and a review of the relevant literature. We aimed to draw clinician’s attention to this side effect of SSRIs.

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Cite This Article

GOKA, E., ASAN, Ö. (2022). Intermenstrual Vaginal Bleeding Due to Sertraline Treatment: A Case Report. Psychiatry and behavioral sciences (Online), Cilt: 9 - Sayı: 3, 139–142. https://ajindex.com/articles/588698

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References (13)

  1. Bottlender R, Dobmeier P, Möller HJ. The effect of selective serotonin reuptake inhibitors in blood coagulation. Fortschr Neurol Psychiatr 1998;66(1):32-35. (German
  2. Serebruany VL. Selective serotonin reuptake inhibitors and increased bleeding risk: are we missing something? Am J Med 2006;119(2):113-116
  3. Alderman CP, Moritz CK, Ben-Towim DI. Abnormal platelet aggregation associated with fluoxetine therapy. Ann Pharmacother 1992;26(12):1517-1519
  4. Nelva A, Guy C, Tardy-Poncet B, Beyens MN, Ratrema M, Benedetti C,Ollagnier M. Bleeding syndromes related to selective serotonin reuptake inhibitors (SSRIs). Seven case reports and literature review. La Revue de Medecine Interne 2000;21(2):152-160
  5. Halperin D, Reber G. Influence of antidepressants on hemostasis. Dialogues in Clinical Neuroscience. 2007;9.1 47
  6. Andrade C, Sharma E. Serotonin reuptake inhibitors and risk of abnormal bleeding. Psychiatr Clin North Am 2016;39(3):413- 426
  7. Joaquim HP, Talib LL, Forlenza OV, Diniz BS, Gattaz WF. Longterm sertraline treatment increases expression and decreases phosphorylation of glycogen syntase kinase 3-B in platelets of patients with late-life major depression. J Psychiatr Res 2012;46(8):1053-1058
  8. Andrade C, Sandarsh S, Chethan KB, Nagesh KS. Serotonin reuptake inhibitor antidepressants and abnormal bleeding: a review for clinicians and a reconsideration of mechanisms. J Clin Psychiatry 2010;71(12):1565-1575
  9. Schelleman H, Brensinger CM, Bilker WB, Hennessy S. Antidepressant-warfarin interaction and associated gastrointestinal bleeding risk in a case-control study. PLoS One 2011;6(6):e21447
  10. Dall M, Schaffalitzky de Muckadell OB, Lassen AT, Hansen JM, Hallas J. An association between selective serotonin reuptake inhibitor use and serious upper gastrointestinal bleeding. Clin Gastroenterol Hepatol 2009;7(12):1314–1321
  11. Kose S, Akin E, Cetin M. Adverse drug reactions and causality: the Turkish version of Naranjo Adverse Drug Reactions Probability Scale. Psychiatry and Clinical Psychopharmacology 2017;27(2):205-206
  12. Mathew D, Desmond P, Isaacs D. Bruising and bleeding with ssris. Australian Advers Drug Reactions Bulletin 1998;17:10-12
  13. Mirsal H, Kalyoncu A, Pektas O. Fluoksetin kullanimi ile ilişkili ekimoz: olgu sunumu [Ecchymosis Associated with The Use of Fluoxetine: Case Report]. Türk Psikiyatri Dergisi 2002;13(4):320-324. [Turkish] 14. Ay R. Paroksetin kullanimi ile ilişkili ekimoz: bir olgu sunumu [Ecchymosis associated wi