Journals / Southern Clinics of Istanbul Eurasia / 2018 / Cilt: 29 - Sayı: 4

The Role of the C-Reactive Protein and Procalcitonin in the Early Diagnosis of Intraabdominal Infection in Critical Patients With a History of Gastrointestinal Surgery

Gastrointestinal Cerrahi Geçirmiş Kritik Hastalarda Erken İntraabdominal Enfeksiyonun Tanısında C-Reaktif Protein ve Prokalsitoninin Rolü

Pages
268–275
Publication Date
2022-10-19
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

The predictivityof postoperative PCT concentrations at the $48^{th}$ and $72^{nd}$ hours is higher regarding infectivecomplications compared to CRP

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The purpose of this study is to determine the roles of c-reactive protein (CRP)and procalcitonin (PCT) in the intraabdominal infective complications of patients undergoinggastrointestinal surgery.Methods: This study is a prospective, single-blinded study.
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Key Findings & Data:The patients’ serum CRP and PCT levels were measured during the $1^{st}$, $24^{th}$, $48^{th}$,and 72nd hours after surgery.
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Conclusion & Impact:The predictivityof postoperative PCT concentrations at the $48^{th}$ and $72^{nd}$ hours is higher regarding infectivecomplications compared to CRP
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: The purpose of this study is to determine the roles of c-reactive protein (CRP)and procalcitonin (PCT) in the intraabdominal infective complications of patients undergoinggastrointestinal surgery.Methods: This study is a prospective, single-blinded study. The subjects were critical patients undergoing gastrointestinal system surgery who had been transferred to the intensivecare unit. The patients’ serum CRP and PCT levels were measured during the $1^{st}$, $24^{th}$, $48^{th}$,and 72nd hours after surgery. Patients with intraabdominal infections were recorded.Results: The study included 49 patients. Of these patients, 38% developed intraabdominalinfections, and the mortality rate was 4%. It was observed that the PCT levels in particularwere statistically very significant at the $48^{th}$ and $72^{nd}$ hours. The sensitivity and specificity ofthe CRP level at the postoperative $48^{th}$ and $72^{nd}$ hours were 78.9% and 70%, respectively.The sensitivity and specificity of the PCT level were 73.7% and 96.7%, respectively, at thepostoperative $48^{th}$ hour, and 84.2% and 90%, respectively, at the $72^{nd}$ hour.Conclusion: The elevated serum PCT and CRP concentrations at the 48- and 72-hourmarkers are critical for the early diagnosis of the intraabdominal infections. The predictivityof postoperative PCT concentrations at the $48^{th}$ and $72^{nd}$ hours is higher regarding infectivecomplications compared to CRP

Özet

Amaç: Bu çalışmanın amacı gastrointestinal cerrahi hastalarının intraabdominal infektif komplikasyonlarında C-reaktif protein (CRP) ve prokalsitoninin (PCT) rolünü belirlemektir. Gereç ve Yöntem: Bu çalışma ileriye yönelik, tek kör bir çalışmadır. Hastalar yoğun bakım ünitesine transfer edilen kritik gastrointestinal sistem cerrahisi hastalarıydı. Hastaların serum CRP ve PCT düzeyleri ameliyat sonrası 1., 24., 48. ve 72. saatlerde ölçüldü. İntraabdominal enfeksiyonlu hastalar kaydedildi. Bulgular: Çalışmaya 49 hasta dahil edilmiştir. Bu hastaların %38’inde intraabdominal enfeksiyon gelişti ve mortalite oranı %4 idi. Özellikle PCT düzeylerinin 48 ve 72. saatlerde istatistiksel olarak anlamlı olduğu görüldü. Duyarlılık ve özgüllük ameliyat sonrası 48. ve 72. saatlerde CRP düzeyinin sırasıyla %78.9 ve %70 olduğu saptandı. PCT düzeyinin duyarlılığı ve özgüllüğü ameliyat sonrası 48. saatte sırasıyla %73.7 ve %96.7 ve 72. saatte sırasıyla %84.2 ve %90 idi. Sonuç: Kırk sekiz ve 72. saatlerde artmış serum PCT ve CRP konsantrasyonları, intraabdominal enfeksiyonların erken teşhisi için kritiktir. Ameliyat sonrası PCT konsantrasyonlarının 48 ve 72. saatlerdeki prediktifliği, CRP’ye kıyasla enfektif komplikasyonlar açısından daha yüksektir

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Cite This Article

TÜRK, H. Ş., ALTINAY, M., AKKER, M., ÇINAR, S. (2022). The Role of the C-Reactive Protein and Procalcitonin in the Early Diagnosis of Intraabdominal Infection in Critical Patients With a History of Gastrointestinal Surgery. Southern Clinics of Istanbul Eurasia, Cilt: 29 - Sayı: 4, 268–275. https://ajindex.com/articles/584721

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