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Journals / Neurological sciences and neurophysiology (Online) / 2021 / Cilt: 38 - Sayı: 3

Antiviral MicroRNA Expression Signatures are Altered in Subacute Sclerosing Panencephalitis

Jens ALLMER
Kürşat Bora ÇARMAN
Erhan BAYRAM
Uluç YİŞ
Yasemin TOPÇU
Semra HIZ
Kemal Uğur TÜFEKÇİ
Şermin GENÇ
Pages
166–172
Publication Date
2022-10-19
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Our findings suggest that antiviral miRNAs are upregulated in patients with SSPE, which could be a part of the host antiviral defense mechanism.

📌 3 Key Takeaways

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Objective & Hypothesis:Background: Subacute sclerosing panencephalitis (SSPE) is a chronic, progressive disease caused by a persistent infection of the measles virus.
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Key Findings & Data:Peripheral blood mononuclear cell levels of miR‐196b, miR‐296, miR‐431, and miR‐448 were analyzed using quantitative polymerase chain reaction.
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Conclusion & Impact:Conclusion: Our findings suggest that antiviral miRNAs are upregulated in patients with SSPE, which could be a part of the host antiviral defense mechanism.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background: Subacute sclerosing panencephalitis (SSPE) is a chronic, progressive disease caused by a persistent infection of the measles virus. Despite extensive efforts, the exact neurodegeneration mechanism in SSPE remains unknown. MicroRNAs (miRNAs) have emerged as an essential part of cellular antiviral defense mechanisms and can be modulated by antiviral cytokines Such as interferon‐beta (IFN‐β). Aims and Objectives: In this study, we aimed to elucidate the role of antiviral miRNAs in the pathogenesis of SSPE and analyze the interaction between host antiviral miRNAs and virus genes. Materials and Methods: Thirty‐seven patients who were followed with SSPE and age‐matched healthy children were included in the study. Peripheral blood mononuclear cell levels of miR‐196b, miR‐296, miR‐431, and miR‐448 were analyzed using quantitative polymerase chain reaction. Target predictions and pathway constructions of deregulated miRNAs were assessed. Results: Here, we showed that IFN‐β‐ modulated miR‐196b, miR‐296, and miR‐431 were significantly upregulated in patients with SSPE compared with healthy controls. Besides, sequence complementarity analysis showed that miR‐296 and miR‐196b predicted binding regions in measles virus genomic RNA. Conclusion: Our findings suggest that antiviral miRNAs are upregulated in patients with SSPE, which could be a part of the host antiviral defense mechanism.

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Cite This Article

ALLMER, J., ÇARMAN, K. B., BAYRAM, E., YİŞ, U., TOPÇU, Y., HIZ, S., TÜFEKÇİ, K. U., GENÇ, Ş. (2022). Antiviral MicroRNA Expression Signatures are Altered in Subacute Sclerosing Panencephalitis. Neurological sciences and neurophysiology (Online), Cilt: 38 - Sayı: 3, 166–172. https://ajindex.com/articles/584314

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