SavedAdd your journal

Journals / Namık Kemal Tıp Dergisi / 2018 / Cilt: 6 - Sayı: 3

MEAN PLATELET VOLUMES OF INFANTS WITH ACUTE BRONCHIOLITIS, IS THERE A CORRELATION BETWEEN THEM?

Akut Bronşiolit Tanılı İnfantlarda Ortalama Platelet Hacmi, İkisi Arasında Bir Korelasyon Var Mı?

Burçin NALBANTOĞLU
Ayşin NALBANTOĞLU
Mustafa Metin DONMA
Nedim SAMANCI
Nuriye Ece MİNTAŞ
Pages
109–116
Publication Date
2022-10-19
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Interms of hospitalization need, no significant difference wasdetected between the MPV values of the hospitalized groupand the outpatients (8,3±0,8 fL; 8,2±0.7 fL, respectively).Conclusions: In conclusion, our data show that MPV valuesare significantly elevated in acute bronchiolitis compared tohealthy infants.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: Acute bronchiolitis is the most common lowerrespiratory tract infection of children younger than 2 years ofage.
📊
Key Findings & Data:Mean platelet volume (MPV) has shownto be effected in inflammatory conditions and to ourknowledge there's only one recent study in children with acutebronchiolitis that demonstrated an association between MPVchange and acute brınchiolitis.Materials and Methods: In this retrospective study weenrolled 555 children diagnosed with Acute bronchiolitis and516 healthy infants with a matching age and sex.Results: MPV levels were found significantly higher in patientgroup (8,2 ± 0,8 fL) than the control group (7,9 ± 0,8 fL).
💡
Conclusion & Impact:Interms of hospitalization need, no significant difference wasdetected between the MPV values of the hospitalized groupand the outpatients (8,3±0,8 fL; 8,2±0.7 fL, respectively).Conclusions: In conclusion, our data show that MPV valuesare significantly elevated in acute bronchiolitis compared tohealthy infants.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: Acute bronchiolitis is the most common lowerrespiratory tract infection of children younger than 2 years ofage. There aren't any standardized diagnostic criteria andseverity assessment classifications for acute bronchiolitisavailable in literature. Mean platelet volume (MPV) has shownto be effected in inflammatory conditions and to ourknowledge there's only one recent study in children with acutebronchiolitis that demonstrated an association between MPVchange and acute brınchiolitis.Materials and Methods: In this retrospective study weenrolled 555 children diagnosed with Acute bronchiolitis and516 healthy infants with a matching age and sex.Results: MPV levels were found significantly higher in patientgroup (8,2 ± 0,8 fL) than the control group (7,9 ± 0,8 fL). Interms of hospitalization need, no significant difference wasdetected between the MPV values of the hospitalized groupand the outpatients (8,3±0,8 fL; 8,2±0.7 fL, respectively).Conclusions: In conclusion, our data show that MPV valuesare significantly elevated in acute bronchiolitis compared tohealthy infants. However, MPV can't be used as a guidance inattack severity nor can it predict hospitalization and systemicsteroid need.

Özet

Amaç: Akut bronşiolit, 2 yaşından küçük çocuklarda en sık görülen alt solunum yolu enfeksiyonudur. Literatürde akut bronşiolit için standart tanı kriterleri ve şiddet değerlendirme sınıflamaları mevcut değildir. Ortalama platelet hacminin (MPV) lokal inflamasyondan etkilendiği gösterilmiştir ve akut bronşiolit ile MPV ilişkisini gösteren tek bir çalışma bulunmaktadır. Materyal ve Metot: Bu çalışmada MPV ile akut bronşiyolit arasındaki ilişkiyi belirlemeyi amaçladık, ayrıca hastalığın şiddetini değerlendirmede yararlı bir belirteç olup olmadığını araştırdık. Bu retrospektif çalışmada akut bronşiolitis tanısı alan 555 çocuğa ve eşleştirilmiş yaş ve cinsiyete sahip 516 sağlıklı bebek çalışma grubuna dahil edilmiştir. Bulgular: MPV düzeyleri hasta grubunda (8,2 ± 0,8 fL) kontrol grubuna (7,9 ± 0,8 fL) göre anlamlı olarak yüksek bulundu. Hastaneye yatış açısından hastaneye yatırılan grup ve poliklinik hastalarının MPV değerleri arasında anlamlı bir fark saptanmamıştır (sırası ile, 8,3 ± 0,8 fL; 8,2 ± 0,7 fL) Sonuç: Sonuç olarak, verilerimiz, akut bronşiolit varlığında MPV değerlerinin sağlıklı bebeklere göre anlamlı derecede yükseldiğini göstermektedir. Bununla birlikte, MPV atak şiddetinde bir rehber olarak kullanılamaz ve hastaneye yatışı ve sistemik steroid ihtiyacını tahmin edemez.

🔖

Cite This Article

NALBANTOĞLU, B., NALBANTOĞLU, A., DONMA, M. M., SAMANCI, N., MİNTAŞ, N. E. (2022). MEAN PLATELET VOLUMES OF INFANTS WITH ACUTE BRONCHIOLITIS, IS THERE A CORRELATION BETWEEN THEM?. Namık Kemal Tıp Dergisi, Cilt: 6 - Sayı: 3, 109–116. https://ajindex.com/articles/584106

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (11)

  1. Neyzi O, Ertuğrul T. Pediatri 4. Baskı. Nobel Tıp Kitabevi, 2010;1086. Coates BM, Camarda LE, and Denise M. Goodman. Wheezing, Bronchitis and Bronchiolitis. In: Behrman RE, ed. Nelson Textbook of Pediatrics. 20th ed. Philadelphia: Elsevier Ltd, 2015;2044-8. García-Salido A, Oñoro G, Melen GJ, Gómez-Piña V, Serrano-González A, Ramírez-Orellana M, et al. Serum sRAGE as a Potential Biomarker for Pediatric Bronchiolitis: A Pilot Study. Lung. 2015;193(1):19-23.
  2. Oymar K, Skjerven HO, Mikalsen IB. Acute bronchiolitis in infants, a review. Scand J Trauma Resusc Emerg Med. 2014; 22: 23. Ralston SL, Lieberthal AS, Meissner HC, Alverson BK, Baley JE, Gadomski AM, et al. Clinical Practice Guideline: The Diagnosis, Management, and Prevention of Bronchiolitis. Pediatrics. 2014;134(5):1474-502.
  3. Mehta R, Scheffler M, Tapia L, Aideyan L, Patel KD, Jewell AM, et al. Lactate dehydrogenase and caspase activity in nasopharyngeal secretions are predictors of bronchiolitis severity. Influenza Other Respi Viruses. 2014;617-25.
  4. J. NP, K. ND. Platelets and the Vessel Wall. In: Orkin SH, Fisher DE, Ginsburg D, Look T, Lux SE, eds. Nathan and Oski’s Hematology and Oncology of Infancy and Childhood. 8th ed. Philadelphia: Elsevier Saunders, 2015; 951-61.
  5. Barrett KE, Barman SM, Boitano S, Brooks HL. Immunity, Infection and Inflammation. In: Barrett KE, Barman SM, Boitano S, Brooks HL, eds. Ganong’s Review of Medical Physiology. 25th ed. Mc Graw Hill Education; 2016;66-83.
  6. Rodgers GM, M.Lehman C. Disorders of Hemostasis and Coagulation. In: John GP, A. AD, Bertil G, F. LA, eds. Wintrobe’s Clinical Hematology. 13th ed. 45: Wolters Kluwer, Lippincott Williams & Wilkins; 2013:2419-2898.
  7. Thompson CB, Jakubowski JA. The pathophysiology and clinical relevance of platelet heterogeneity. Blood. 1988;72(1):1-8.
  8. Park Y, Schoene N, Harris W. Mean platelet volume as an indicator of platelet activation: Methodological issues. Platelets. 2002;13:301-6. Christof D. Thrombocytosis. In: Arceci RJ, Hann IM, Smith OP, Victor HA, eds. Pediatric Hematology. 3rd ed. Massachusetts: Blackwell Publishing Ltd.; 2006;548-51.
  9. Morrell CN, Aggrey AA, Chapman LM, Modjeski KL. Emerging roles for platelets as immune and inflammatory cells. Blood. 2016;123(18):2759-68.
  10. Golcuk Y, Golcuk B, Bilge A, Irik M, Dikmen O. Combination of mean platelet volume and the CURB-65 score better predicts 28-day mortality in patients with community-acquired pneumonia. Am J Emerg Med. 2015;33(5):648-52.
  11. Tural Kara T, Yılmaz Özbek Ö, Tahire