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Journals / Medeniyet Medical Journal / 2016 / Cilt: 31 - Sayı: 3

Evaluation of red cell distribution width (RDW) in diabetic nephropathy patients

Diyabetik nefropati hastalarında eritrosit dağılım aralığının (RDW) değerlendirilmesi

Mümtaz TAKIR
Ahsen YILMAZ
Murat AYDIN
Bülent BİLİR
Betül EEKİZ BİLİR
Neslihan SOYSAL ATİLE
Pages
156–160
Publication Date
2022-10-19
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Fasting blood glucose, HbA1c, LDLcholesterol levels and duration of diabetes were statistically significantly different (respectively p=0.01, 0.01, 0.048,

📌 3 Key Takeaways

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Objective & Hypothesis:Diabetic nephropathy (DN) is an important cause of morbidity andmortality of diabetes mellitus (DM) patients.
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Key Findings & Data:We aimed to compare levels RDWwhich is a marker of inflammation between DM patients with andwithout diabetic nephropathy and also evaluate the effect of diabetic nephropathy on RDW in a total of 101 type 2 DM patients (58diabetic nephropathy patients and 43 patients without diabeticnephropathy).
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Conclusion & Impact:Fasting blood glucose, HbA1c, LDLcholesterol levels and duration of diabetes were statistically significantly different (respectively p=0.01, 0.01, 0.048,
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Diabetic nephropathy (DN) is an important cause of morbidity andmortality of diabetes mellitus (DM) patients. Inflammation has apivotal role in DN pathogenesis. Red cell distribution width (RDW)is a current parameter which has been supposed to be a markerof ineffective erythropoiesis depending on chronic inflammationand neurohumoral activation. We aimed to compare levels RDWwhich is a marker of inflammation between DM patients with andwithout diabetic nephropathy and also evaluate the effect of diabetic nephropathy on RDW in a total of 101 type 2 DM patients (58diabetic nephropathy patients and 43 patients without diabeticnephropathy). All clinical and laboratory data including BUN, creatinine, hemogram, fasting blood glucose, HbA1c, lipid profile, andblood pressure levels were recorded. SPSS 17.0 was used for thestatistical analysis of data. RDW values of diabetic nephropathypatients was significantly higher than those of patients without diabetic nephropathy (p=0.032). Fasting blood glucose, HbA1c, LDLcholesterol levels and duration of diabetes were statistically significantly different (respectively p=0.01, 0.01, 0.048,

Özet

Diyabetik nefropati, diyabetes mellitüsün (DM) en sık mortalite ve morbidite nedenlerindendir. Diyabetik nefropatinin patogenezinde ve ilerlemesinde inflamasyonun önemli bir rolü vardır. Eritrosit dağılım aralığı (RDW), kronik inflamasyon ve nörohumoral aktivasyona bağlı inefektif eritropoezisi gösterdiği düşünülen yeni bir risk belirteci olarak tanımlanmış güncel bir parametredir. Bu çalışmada, nefropatisi olan ve olmayan toplam 101 tip 2 DM (58 diyabetik nefropati ve 43 nefropatisi olmayan diyabetik) hastada, bir inflamasyon belirteci olarak RDW düzeylerini karşılaştırıp, diyabetik nefropatinin bu parametre üzerinde etkisini incelemeyi amaçladık. Hastaların üre, kreatinin, hemogram, açlık kan şekeri, HbA1c, lipid profili ve kan basıncı düzeyini içeren klinik ve laboratuvar verileri kaydedildi. İstatistiksel analizler SPSS 17.0 versiyonu ile yapıldı. Diyabetik nefropati grubunda RDW düzeyi nefropatisi olmayan diyabetik gruptan anlamlı olarak yüksek bulunmuştur (p=0,032). Gruplar arası karşılaştırmada; AKŞ, HbA1c, LDL ve DM yaşı açısından istatistiksel olarak anlamlı fark saptanırken (p değerleri sırasıyla; 0,01, 0,01, 0,048,

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Cite This Article

TAKIR, M., YILMAZ, A., AYDIN, M., BİLİR, B., BİLİR, B. E., ATİLE, N. S. (2022). Evaluation of red cell distribution width (RDW) in diabetic nephropathy patients. Medeniyet Medical Journal, Cilt: 31 - Sayı: 3, 156–160. https://ajindex.com/articles/579351

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