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Journals / Kocaeli Tıp Dergisi / 2019 / Cilt: 8 - Sayı: 1

Prohepcidin levels in Familial Mediterranean Fever: Possible effect of iron metabolism?

Ailesel Akdeniz Ateşinde prohepsidin seviyeleri: Demir metabolizmasının rolü var mı?

Mustafa KAPLAN
Yusuf YAZGAN
Şükrü ÖZAYDIN
Tolga DÜZENLİ
Levent DEMİRTÜRK
Ahmet Kemal GÜRBÜZ
Alparslan TANOĞLU
Osman Metin İPÇİOĞLU
Kemal ÖNCÜ
Melih ÖZEL
Pages
91–96
Publication Date
2022-10-18
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Prohepcidin, interleukin-6 (IL-6), serum iron, serum iron binding capacity, ferritin, fibrinogen and erythrocyte sedimentation rate were analyzed.RESULTS: Prohepcidin levels was significantly lower in patient group than control group, wheras IL-6 levels was significantly higher (p

📌 3 Key Takeaways

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Objective & Hypothesis:INTRODUCTION: Familial Mediterranean Fever (FMF) is a systemic autoinflammatory disorder.
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Key Findings & Data:Hepcidin is an acid peptide mainly involved in iron regulation that increases by inflammation and infection.
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Conclusion & Impact:Prohepcidin, interleukin-6 (IL-6), serum iron, serum iron binding capacity, ferritin, fibrinogen and erythrocyte sedimentation rate were analyzed.RESULTS: Prohepcidin levels was significantly lower in patient group than control group, wheras IL-6 levels was significantly higher (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

INTRODUCTION: Familial Mediterranean Fever (FMF) is a systemic autoinflammatory disorder. Hepcidin is an acid peptide mainly involved in iron regulation that increases by inflammation and infection. In this study; we aimed to evaluate the relationship between the hepcidin levels and FMF attacks, and to determine the likely role of hepcidin in the diagnosis of the disease.METHODS: 42 male patients and 28 healthy male controls were included in the study. Prohepcidin, interleukin-6 (IL-6), serum iron, serum iron binding capacity, ferritin, fibrinogen and erythrocyte sedimentation rate were analyzed.RESULTS: Prohepcidin levels was significantly lower in patient group than control group, wheras IL-6 levels was significantly higher (p

Özet

GİRİŞ ve AMAÇ: Ailesel Akdeniz Ateşi sistemik otoinflamatuar bir hastalıktır. Hepsidin ise demir metabolizamasında rol oynayan inflamasyon ve enfeksiyonda yükselen bir peptiddir. Biz çalışmamızda Ailesel Akdeniz Ateşi ataklarında hepsidin düzeylerini ve hastalık patogenezinde hepsidinin olası rolünü araştırmayı hedefledik. YÖNTEM ve GEREÇLER: Çalışmamıza 42 erkek hasta ve 28 erkek kontrol dahil edildi. Hastaların ataklı ve ataksız dönemlerinden ve kontrol hastalarından prohepsidin, interlökin-6, serum demiri, serum demir bağlama kapasitesi, ferritin, fibrinojen ve eritrosit sedimantasyon oranı değerleri analiz edildi. BULGULAR: Hasta grubunun serum prohepsidin seviyeleri kontrol grubuna göre düşük iken, IL-6 seviyeleri hasta grubunda anlamlı yüksek saptandı (p

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Cite This Article

KAPLAN, M., YAZGAN, Y., ÖZAYDIN, Ş., DÜZENLİ, T., DEMİRTÜRK, L., GÜRBÜZ, A. K., TANOĞLU, A., İPÇİOĞLU, O. M., ÖNCÜ, K., ÖZEL, M. (2022). Prohepcidin levels in Familial Mediterranean Fever: Possible effect of iron metabolism?. Kocaeli Tıp Dergisi, Cilt: 8 - Sayı: 1, 91–96. https://ajindex.com/articles/574771

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