Journals / Klinik Psikofarmakoloji Bülteni / 2006 / Cilt: 16 - Sayı: 3

Factors associated with response to pharmacotherapy in obsessive-compulsive disorder

Obsesif kompulsif bozuklukta ilaç tedavisine yanıt ile ilişkili etkenler

Pages
207–212
Publication Date
2022-10-17
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

In our article, sociodemographic, clinical and biological factors associated with response to pharmacotherapy in OCD are reviewed

📌 3 Key Takeaways

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Objective & Hypothesis:In the last two decades, although pharmacotherapy of obsessivecompulsive disorder (OCD) has made notable advance with the use of serotonin reuptake inhibitors (SRIs), a considerable proportion of patients with OCD remain as non-responders or partially responders.
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Key Findings & Data:For this reason, the studies evaluating the clinical and biological factors associated with the positive response to pharmacotherapy in OCD patients have increased.
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Conclusion & Impact:In our article, sociodemographic, clinical and biological factors associated with response to pharmacotherapy in OCD are reviewed
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

In the last two decades, although pharmacotherapy of obsessivecompulsive disorder (OCD) has made notable advance with the use of serotonin reuptake inhibitors (SRIs), a considerable proportion of patients with OCD remain as non-responders or partially responders. For this reason, the studies evaluating the clinical and biological factors associated with the positive response to pharmacotherapy in OCD patients have increased. To date consensus regarding the factors associated positive response to pharmacotherapy has not yet been reached. In our article, sociodemographic, clinical and biological factors associated with response to pharmacotherapy in OCD are reviewed

Özet

Obsesif kompulsif bozukluğun (OKB) ilaç tedavisinde son yirmi yılda serotonin gerialım inhibitörlerinin (SGİ) kullanımı ile ilgili önemli gelişmeler olmasına rağmen, OKB’li hastaların önemli bir kısmı ilaç tedavisine yanıt vermemekte veya kısmi yanıt vermektedir. Bundan dolayı OKB hastalarında ilaç tedavisine yanıtla ilişkili etkenleri inceleyen çalışmalar giderek artmaktadır. Ancak ilaç tedavisine yanıt ile ilişkili özellikler hakkında hâlâ bir görüş birliği oluşmamıştır. Bu derleme yazısında OKB’de ilaç tedavisine yanıtla ilişkili sosyodemografik, klinik ve biyolojik etkenler gözden geçirilmiştir.

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Cite This Article

AŞKIN, R., UĞUZ, F. (2022). Factors associated with response to pharmacotherapy in obsessive-compulsive disorder. Klinik Psikofarmakoloji Bülteni, Cilt: 16 - Sayı: 3, 207–212. https://ajindex.com/articles/574395

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References (12)

  1. Goodman WK, McDougle CJ, Price LH. Pharmacotherapy of obsessive-compulsive disorder. J Clin Psychiatry 1992; 53(Suppl.4): S29-S37 Perugi G, Akiskal HS, Gemignani A, Pfanner C, Presta S, Milanfranchi A, Lensi P, Ravagli S, Maremmani I, Cassano GB. Epizodic course in obsessive-compulsive disorder. Eur Arch Psychiatry Clin Neurosci 1998; 248: 240-244
  2. Fontanelle LF, Mendlowicz AAV, Marques C, Versiani M. Early- and late-onset obsessive-compulsive disorder in adult patients: an expiatory clinical and therapeutic study. J Psychiatr Res 2003; 37: 127-133
  3. Steketee G, Eisen JL, Dyck I, Warshaw M, Rasmussen S. Predictors of course in obsessive-compulsive disorder. Psychiatry Res 1999; 89:229-238
  4. Eisen JL, Goodman WK, Keller MB, Warshaw MG, DeMarco LM, Luce DD, Rasmussen SA. Patterns of remission and relaps in obsessive-compulsive disorder: A 2-year prospective study. J Clin Psychiatry 1999; 60: 346-351
  5. Ackerman DL, Greenland S, Bystritsky A. Clinical characteristics of response to fluoksetine treatment of obsessive-compulsive disorder. J Clin Psychopharmacol 1998; 18:185-192
  6. Erzegovesi S, Cavallini MC, Cavedini P, Diaferia G, Locatelli M, Bellodi L. Clinical predictors of drug response in obsessive- compulsive disorder. J Clin Psychopharmacol 2001; 21: 488-492
  7. Denys D, Burger H, van Megan H, de Geus F, Westenberg H. A score for predicting response to pharmacotherapy in obsessive- compulsive disorder. Int Clin Psychopharmacol 2003; 18: 315-322
  8. Kishore RV, Samar R, Janardhan Reddy YC, Chandrasekhar CR, Thennarasu K. Clinical characteristics and treatment response in poor and good insight obsessive-compulsive disorder. Eur Psychiatry 2004; 19: 202-208
  9. Alonso P, Menchon JM, Pifarre J, Mataix-Cols D, Torres L, Salgado P, Vallejo J. Long-term follow-up and predictors of clinical outcome in obsessive-compulsive patients treated with serotonin reuptake inhibitors and behavioral therapy. J Clin Psychiatry 2001; 62: 535- 540 Stein DJ, Montgomery SA, Kasper S, Tanghoj P. Predictors of response to pharmacotherapy with citalopram in obsessive- compulsive disorder. Int Clin Psychopharmacol 2001; 16: 357-361
  10. Alarcon RD, Libb JW, Spitler D. A predictive study of obsessive- compulsive disorder. J Clin Psychopharmacol 1993; 13: 210-213
  11. Ackerman DL, Greenland S, Bystritsky A, Morgenstern H, Katz RJ. Predictors of treatment response in obsessive-compulsive disorder: Multivarite analyses from a multicenter trial of clomipramine. J Clin Psychopharmacol 1994; 14: 247-254
  12. Moritz S, Fricke