Journals / Klinik Psikofarmakoloji Bülteni / 2009 / Cilt: 19 - Sayı: 2

The effect of quetiapine on alcohol/drug dependents and its abuse: A case series and literature review

Alkol/madde bağımlılarında ketiapinin etkisi ve kötüye kullanımı: Olgu serisi ve gözden geçirme

Pages
148–154
Publication Date
2022-10-17
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

We also reviewed the literature concerning the effectiveness and abuse potentiality of quetiapine in substance dependent patients.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Quetiapine is an atypical antipsychotic drug, which has been found to be effective in the treatment of schizophrenia, bipolar disorder, and related disorders.
📊
Key Findings & Data:In this report we presented 3 cases of inpatients at an addiction treatment center with the suspicion of quetiapine abuse.
💡
Conclusion & Impact:We also reviewed the literature concerning the effectiveness and abuse potentiality of quetiapine in substance dependent patients.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Quetiapine is an atypical antipsychotic drug, which has been found to be effective in the treatment of schizophrenia, bipolar disorder, and related disorders. Recent studies report the effectiveness of quetiapine among patients with substance use disorders both as a single disorder and as a comorbid disorder with the aforementioned disorders. Case reports have accumulated evidence suggesting that quetiapine may also be abused. In this report we presented 3 cases of inpatients at an addiction treatment center with the suspicion of quetiapine abuse. We also reviewed the literature concerning the effectiveness and abuse potentiality of quetiapine in substance dependent patients.

Özet

Ketiapin atipik antipsikotik olarak değerlendirilen ve şizofrenik bozukluk, bipolar bozukluk ve ilişkili durumların tedavisinde etkinliği kanıtlanmış bir ilaçtır. Son dönemde yapılan çalışmalarda, hem bu bozukluklarla komorbid hem de tek başına olan alkol/madde kullanım bozukluğunda ketiapinin etkinliğinden bahsedilmektedir. Ancak aynı zamanda ketiapin kötüye kullanımını düşündüren vaka bildirimleri de giderek artmaktadır. Bu yazıda bir bağımlılık merkezinde aynı hafta içinde yatarak tedavi olan ve ketiapini kötüye kullandıkları şüphesi oluşan 3 olgu sunulmuştur. Ayrıca bu vakalar doğrultusunda ketiapinin alkol/madde bağımlılığında hem etkinliği hem de kötüye kullanımı ile ilgili literatür gözden geçirilmiştir

🔖

Cite This Article

AYDIN, A., EVREN, C., CAKMAK, D., KARATEPE, H. T., DALBUDAK, E. (2022). The effect of quetiapine on alcohol/drug dependents and its abuse: A case series and literature review. Klinik Psikofarmakoloji Bülteni, Cilt: 19 - Sayı: 2, 148–154. https://ajindex.com/articles/574300

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (15)

  1. Reeves RR, Brister JC. Additional Evidence of the Abuse Potential of Quetiapine. South Med J 2007;100:834-836
  2. Adityanjee Schulz SC. Clinical use of quetiapine in disease states other than schizophrenia. J Clin Psychiatry 2002;63 (Suppl 13):32–38
  3. Hussain MZ, Waheed W, Hussain S. Intravenous Quetiapine Abuse. Am J Psychiatry 2005;162:1755-1756
  4. Brown ES, Nejtek VA, Perantie DC, Bobadilla L. Quetiapine in bipolar disorder and cocaine dependence. Bipolar Disord 2002;4:406–411
  5. Cruz HA, Haider S. Effectiveness of quetiapine in patients with dual diagnosis (poster). Presented at the: APAInstitute on Psychiatr Serv, Orlando, FL, 2001
  6. Weisman RL. Quetiapine in the successful treatment of schizophrenia with comorbid alcohol and drug dependence: a case report. Int J Psychiatry Med 2003;33:85-89
  7. Brown ES, Nejtek VA, Perantie DC, Rajan Thomas N, Rush AJ. Cocaine and amphetamine use in patients with psychiatric illness: a randomized trial of typical antipsychotic continuation or discontinuation. J Clin Psychopharmacol 2003;23:384-388
  8. Potvin S, Stip E, Lipp O, Elie R, Mancini-Marië A, Demers MF, Roy MA, Bouchard RH, Gendron A. Quetiapine in patients with comorbid schizophrenia-spectrum and substance use disorders: an open-label trial. Curr Med Res Opin 2006;22:1277-1285
  9. Martinotti G, Andreoli S, Di Nicola M, Sarchiapone M, Janiri L. Quetiapine decreases alcohol consumption, craving, and psychiatric symptoms in dually diagnosed alcoholics. Hum Psychopharmacol 2008
  10. Brown ES, Garza M, Carmody TJ. A Randomized, Double-Blind, Placebo-Controlled Add-On Trial of Quetiapine in Outpatients With Bipolar Disorder and Alcohol Use Disorders. J Clin Psychiatry 2008:e1-e5
  11. Pinkofsky HB, Hahn AM, Campbell FA, Rueda J, Daley DC, Douaihy AB. Reduction of opioid-withdrawal symptoms with quetiapine. J Clin Psychiatry 2005;66:1285-1288
  12. Monnelly EP, Ciraulo DA, Knapp C, LoCastro J, Sepulveda I: Quetiapine for treatment of alcohol dependence. J Clin Psychopharmacol 2004;24:532–535
  13. Croissant B, Klein O, Gehrlein L, Kniest A, Hermann D, Diehl A, Mann K. Quetiapine in relapse prevention in alcoholics suffering from craving and affective symptoms: a case series. Eur Psychiatry 2006; 21: 570–573
  14. Mariani JJ, Levin FR. Quetiapine Treatment of Zolpidem Dependence. Am J Addict 2007;16:426
  15. Kampman KM, Pettinati HM, Lynch KG, Whittingham T, Macfadden W, Dackis C, Tirado C, Oslin DW, Sparkman T, O'Brien CP. A double-blind, placebo-controlled p