SavedAdd your journal

Journals / Klinik Psikofarmakoloji Bülteni / 2010 / Cilt: 20 - Sayı: 1

Obsesif kompulsif bozuklukta 5-HT1DB geni ile anahtar beyin bölgeleri arasındaki ilişki

Serotonin 5-HT1DB gene’s interaction with key brain regions in obsessive-compulsive disorder

Osman MERMİ
Murad ATMACA
Mustafa KOÇ
Sevda KORKMAZ
Ebru ONALAN
Hanefi YİLDİRİM
Sinan OZLER
Hüseyin YUCE
Bilge KARA
Pages
23–28
Publication Date
2022-10-17
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The stronger effect of 5-HT1DB polymorphism on brain morphology in OCD patients than those in controls were determined in the OFC (P

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: The interaction between neuroanatomical and genetic variables in obsessive-compulsive disorder (OCD) was not studied well.
📊
Key Findings & Data:The aim of this study was to examine whether the 5-HT1DB gene polymorphism has an impact on brain morphology in normal subjects and patients with OCD.Method: Forty-four patients and 44 healthy controls were studied.
💡
Conclusion & Impact:The stronger effect of 5-HT1DB polymorphism on brain morphology in OCD patients than those in controls were determined in the OFC (P
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: The interaction between neuroanatomical and genetic variables in obsessive-compulsive disorder (OCD) was not studied well. The aim of this study was to examine whether the 5-HT1DB gene polymorphism has an impact on brain morphology in normal subjects and patients with OCD.Method: Forty-four patients and 44 healthy controls were studied. Brain volume measurements of subjects’ structural MRI were performed on certain regions of interests such as orbito-frontal cortex (OFC) and thalamus. Genotyping for the 5-HT1B receptor gene G861C polymorphism was performed using venous blood samples.Results: We found significant genotype-diagnosis interaction effects on brain morphology. The stronger effect of 5-HT1DB polymorphism on brain morphology in OCD patients than those in controls were determined in the OFC (P

Özet

Amaç: Obsesif kompulsif bozuklukta (OKB) nöroanatomik ve genetik değişkenler arasındaki ilişkiyi inceleyen oldukça sınırlı sayıda çalışma bulunmaktadır. Bu çalışmanın amacı, 5-HT1DB gen polimorfizminin OKB’li hastalarla sağlıklı kontrollerde beyin morfolojisi üzerine olan etkilerini incelemektir.Metod: Çalışmada 44 hasta ve aynı sayıda kontrol denek değerlendirildi. Deneklerin talamus ve orbito-frontal korteks (OFC) bölgelerinin manyetik rezonans görüntülemesi gerçekleştirildi. Ek olarak venöz kan örneklemlerinden 5-HT1B reseptor geni G861C polimorfizmi için genotipleme yapıldı.Bulgular: Genotip ve tanı arasındaki ilişkinin çalışılan beyin volümleriyle ilişkili olduğunu gözlemledik. OFC bölgesinde 5-HT1DB polimorfizminin beyin morfolojisi üzerindeki etkisi hasta grubunda, kontrollere göre anlamlı olarak daha belirgindi (P

🔖

Cite This Article

MERMİ, O., ATMACA, M., KOÇ, M., KORKMAZ, S., ONALAN, E., YİLDİRİM, H., OZLER, S., YUCE, H., KARA, B. (2022). Obsesif kompulsif bozuklukta 5-HT1DB geni ile anahtar beyin bölgeleri arasındaki ilişki. Klinik Psikofarmakoloji Bülteni, Cilt: 20 - Sayı: 1, 23–28. https://ajindex.com/articles/574204

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (12)

  1. Demet MM. Obsesif kompulsif bozuklukta genetik çalışmalar. Klinik Psikofarmakoloji Bülteni 2005;15:45-52
  2. Yaşan A, Gürgen F. Obsesif kompulsif bozuklukta elektroensefalografi bulguları. Klinik Psikofarmakoloji Bülteni 2004; 14:61-67
  3. Whiteside SP, Port JD, Abramowitz JS. A meta-analysis of functional neuroimaging in obsessive-compulsive disorder. Psychiatry Res 2004;132:69-79
  4. Scarone S, Colombo C, Livian S, Abbruzzese M, Ronchi P, Locatelli M, Scotti G, Smeraldi E. Increased right caudate nucleus size in obsessive-compulsive disorder: detection with magnetic resonance imaging. Psychiatry Res 1992; 45:115–121
  5. Robinson D, Wu H, Munne RA, Ashtari M, Alvir JM, Lerner G, Koreen A, Cole K, Bogerts B. Reduced caudate nucleus volume in obsessive-compulsive disorder. Arch Gen Psychiatry 1995;52:393–398
  6. Szeszko PR, Robinson D, Alvir JM, Bilder RM, Lencz T, Ashtari M, Wu H, Bogerts B. Orbital frontal and amygdala volume reductions in obsessive-compulsive disorder. Arch Gen Psychiatry 1999;56:913–919
  7. Jenike MA, Breiter HC, Baer L, Kennedy DN, Savage CR, Olivares MJ, O'Sullivan RL, Shera DM, Rauch SL, Keuthen N, Rosen BR, Caviness VS, Filipek PA. Cerebral structural abnormalities in obsessive-compulsive disorder. A quantitative morphometric magnetic resonance imaging study. Arch Gen Psychiatry 1996; 53:625-632
  8. O'Sullivan RL, Rauch SL, Breiter HC, Grachev ID, Baer L, Kennedy DN, Keuthen NJ, Savage CR, Manzo PA, Caviness VS, Jenike MA. Reduced basal ganglia volumes in trichotillomania measured via morphometric magnetic resonance imaging. Biol Psychiatry 1997;42:39-45
  9. Bartha R, Stein MB, Williamson PC, Drost DJ, Neufeld RW, Carr TJ, Canaran G, Densmore M, Anderson G, Siddiqui AR. A short echo 1H spectroscopy and volumetric MRI study of the corpus striatum in patients with obsessive-compulsive disorder and comparison subjects. Am J Psychiatry 1998;155:1584–1591
  10. Rosenberg DR, Benazon NR, Gilbert A, Sullivan A, Moore GJ. Thalamic volume in pediatric obsessive–compulsive disorder patients before and after cognitive behavioral therapy. Biol Psychiatry 2000;48:294-300
  11. Riffkin J, Yucel M, Maruff P, Wood SJ, Soulsby B, Olver J, Kyrios M, Velakoulis D, Pantelis C. Amanual and automated MRI study of anterior cingulate and orbito-frontal cortices, and caudate nucleus in obsessive-compulsive disorder: comparison with healthy controls and patients with schizophrenia. Psychiatry Res 2005;138:99-113
  12. Atmaca M, Yildirim H, Ozdemi, H, Tezcan