Journals / Klinik Psikofarmakoloji Bülteni / 2011 / Cilt: 21 - Sayı: 3

Neurosyphilis in the differential diagnosis of late onset psychiatric disorders: Case reports

Geç başlangıçlı psikiyatrik tabloların ayırıcı tanısında nörosifiliz: Olgu sunumları

Pages
258–261
Publication Date
2022-10-17
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This report shows the importance of neurosyphilis in the differential diagnosis of late onset psychiatric disorders and atypical clinical presentations.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Neurosyphilis is a form of tertiary syphilis infection caused by the spirochete bacterium Treponema Pallidum.
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Key Findings & Data:Frequent use of antibiotics has altered the natural course of syphilis and late-stage neurosyphilis has begun to be seen in different clinical forms.
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Conclusion & Impact:This report shows the importance of neurosyphilis in the differential diagnosis of late onset psychiatric disorders and atypical clinical presentations.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Neurosyphilis is a form of tertiary syphilis infection caused by the spirochete bacterium Treponema Pallidum. Frequent use of antibiotics has altered the natural course of syphilis and late-stage neurosyphilis has begun to be seen in different clinical forms. Neurosyphilis may present with neuropsychiatric symptoms and may mimic virtually any psychiatric disorder, such as psychosis, delirium, personality changes and mood disorders. Here, we present two patients investigated for syphilis serology because of late-onset psychiatric illness with predominant mood symptoms. The first case was diagnosed as confirmed neurosyphilis and the second case as presumptive neurosyphilis. They were given penicillin treatment and marked improvement in the clinical picture was observed. This report shows the importance of neurosyphilis in the differential diagnosis of late onset psychiatric disorders and atypical clinical presentations.

Özet

Nörosifiliz, bir spiroket olan Treponema Pallidumun sebep olduğu sifilizin klinik bir formudur. Antibiyotiklerin yaygın kullanımı, sifilizin doğal seyrini değiştirerek geç dönem nörosifilizin farklı klinik görünümlerde ortaya çıkmasına sebep olmuştur. Nörosifiliz, nöropsikiyatrik belirtilerle kendini gösterebilir ve psikoz, deliryum, kişilik değişiklikleri, duygudurum bozuklukları gibi bir çok psikiyatrik bozukluğu taklit edebilir. Duygudurum belirtileri belirgin geç başlangıçlı psikiyatrik tablo sebebiyle sifiliz serolojisinin araştırıldığı iki olgu sunulmuştur. İlk olguya kesin nörosifiliz , ikinci olguyaolası nörosifiliz tanısıyla penisilin tedavisi uygulanmış ve klinik cevap elde edilmiştir. Bu yazı, geç başlangıçlı psikiyatrik hastalıkların ve atipik klinik tabloların ayırıcı tanısında nörosifilizin önemini vurgulamaktadır.

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Cite This Article

GENÇ, A., KARAMUSTAFALIOĞLU, N., İLNEM, C., YENER, F., GÜNGÖR, F. C. (2022). Neurosyphilis in the differential diagnosis of late onset psychiatric disorders: Case reports. Klinik Psikofarmakoloji Bülteni, Cilt: 21 - Sayı: 3, 258–261. https://ajindex.com/articles/574191

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References (14)

  1. Öncel Ç, Erdoğan Ç, Oğuzhanoğlu A, Can İ. Atipik bir nörosifiliz vakası. Düşünen Adam: Psikiyatri ve Nörolojik Bilimler Dergisi 2007; 20(1):54-8
  2. Akın L. Türkiye’de cinsel yolla bulaşan enfeksiyonların epidemiyolojisi. Türkiye Klinikleri 2006; 26 (6): 655-65
  3. Schmidt RP. Neurosyphilis. In Clinical Neurology Vol. 2 Chap
  4. Joynt RJ (editor). Rev ed. JB Lippincott Company Philadelphia: 1992. p.1-23
  5. Stamm WE, Handsfield HH, Rompalo AM. The association of genital ulcer disease and the acquisition of HIV infection in homosexual men. JAMA 1998; 260 (10):1429
  6. Mandell GL, Bennett JE and R Dolin. Mandel, Douglas, and Bennett’s: Principles and Practice of Infectious Diseases. 6th ed. Churchill Livingstone; 2005 6. Ropper AH, Brown RH. Adams and Victor’s Principles of Neurology. Murat Emre (çev.ed) 8.baskı, İstanbul:Güneş Kitabevi, 2006. p.592-31
  7. Ghanem KG. Neurosyphilis: A Historical Perspective and Review CNS Neurosci Ther 2010;16(5):157-68
  8. French P. Clinical Review: Syphilis. BMJ 2007; 334(7585):143-7
  9. Hutto B. Syphilis in clinical psychiatry: a review. Psychosomatics 2001;42(6):453-60
  10. Russouw HG, Roberts MC, Emsley RA, Truter R. Psychiatric manifestations and magnetic resonance imaging in HIV-negative neurosyphilis. Biol Psychiatry 1997;41(4):467-73
  11. Tselis A, Booss J. Behavioral consequences of infections of the central nervous system: with emphasis on viral infections. J Am Acad Psychiatry Law 2003; 31(3):289-98
  12. Tomruk NB, Karamustafalıoğlu N, Kükürt R, Alpay N. Nörosifiliz: bir vaka sunumu. Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology 1998; 8(4):235-40
  13. Larsen SA, Steiner BM, Rudolph AH. Laboratory diagnosis and interpretation of tests for syphilis. Clin Microbiol Rev 1995;8(1):1- 21
  14. Workowski KA, Berman SM. Centers for Disease Control and Prevention. Sexually transmitted diseases treatment guidelines. MMWR Recomm Rep 2006;55 (1):1-94.