Journals / Klinik Psikofarmakoloji Bülteni / 2011 / Cilt: 21 - Sayı: 2

Asperger sendromu ile şizofreni birlikteliği ve klozapin kullanımı

Comorbid Asperger’s syndrome and schizophrenia and use of clozapine

Pages
147–149
Publication Date
2022-10-17
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Clozapine might be a safe and effective treatment choice in patients with co-morbid Asperger’s syndrome and schizophrenia.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:There is a debate concerning comorbid Asperger’s syndrome and schizophrenia which eventually influences patient management.
📊
Key Findings & Data:A 26 year old man with insomnia, irritability, aggressive behaviors, delusions (reference, persecutory and thought broadcasting), auditory hallucinations, and loss of pleasure in his interests for two years was admitted to our inpatient unit.
💡
Conclusion & Impact:Clozapine might be a safe and effective treatment choice in patients with co-morbid Asperger’s syndrome and schizophrenia.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

There is a debate concerning comorbid Asperger’s syndrome and schizophrenia which eventually influences patient management. Comorbid schizophrenia with Asperger’s syndrome cases have been mostly treated with risperidone. A 26 year old man with insomnia, irritability, aggressive behaviors, delusions (reference, persecutory and thought broadcasting), auditory hallucinations, and loss of pleasure in his interests for two years was admitted to our inpatient unit. His initial assessment, according to the positive and negative syndrome scale (PANSS) was 109 points and clozapine 12.5mg/day was initiated and titrated up to 200mg/day. In his childhood he had been diagnosed with Asperger’s Syndrome because of stereotypic behaviors and odd interests. He was discharged with a PANSS score of 65 points at week seven. Clozapine might be a safe and effective treatment choice in patients with co-morbid Asperger’s syndrome and schizophrenia.

Özet

Asperger sendromu ve şizofreni birlikteliği ile ilgili şüphe vardır ve bu hastalığın tedavisini etkilemektedir. Asperger sendromu ve şizofreni tanı birlikteliğinde çoğunlukla risperidon kullanılmıştır. 26 yaşındaki erkek hastada son 2 yılda giderek artan miktarda, uykusuzluk, irritabilite, agresif davranışlar, referans, perseküsyon ve düşünce yayınlanması hezeyanları, daha önceki ilgi alanlarına karşı zevk alamama şikayetleri ile servise yatışı yapıldı. Klinikteki ilk değerlendirmesinde pozitif ve negatif sendrom skalası (PANSS) puanı 109‘du ve klozapin 12.5 mg/gün başlanarak, doz arttırımı ile 200 mg/ güne yükseltildi. Çocukluk çağında stereotipik ve değişik ilgi alanları nedeniyle Asparger sendromu tanısı almış. Hastanın tedavisinin 7. haftasının sonunda PANSS skoru 65 puana geriledi. Klozapin, Asperger sendromu ve şizofreni birlikteliğinde güvenilir ve etkin bir tedavi ajanı olabilir.

🔖

Cite This Article

YANARTAŞ, Ö., ÇITAK, S., YILMAZ, Y., KARA, H., SAYGILI, İ. (2022). Asperger sendromu ile şizofreni birlikteliği ve klozapin kullanımı. Klinik Psikofarmakoloji Bülteni, Cilt: 21 - Sayı: 2, 147–149. https://ajindex.com/articles/574156

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (8)

  1. Lainhart JE. Psychiatric problems in individuals with autism, their parents and siblings. Int Rev Psychiatry 1999;11:278-98
  2. Skokauskas N, Gallagher L. Psychosis, Affective Disorders and Anxiety in Autistic Spectrum Disorder: Prevalence and Nosological Considerations. Psychopathology 2010;43:8-16
  3. Raja M, Azzoni A. Thought disorder in Asperger syndrome and schizophrenia: Issues in the differential diagnosis. A series of case reports. The World Journal of Biological Psychiatry 2009; 10(4):944-52
  4. Bilgic A, Kilic GB, Kilic ZE. An adolescent case with asperger disorder and comorbid schizophrenia responded clozapine. Bull Clinical Psychopharmacology 2009; 19(4):423-7
  5. Wheeler A, Humberstone V, Robinson G. Outcomes for schizophrenia patients with clozapine treatment: how good does it get? J Psychopharmacology 2009;23(8): 957-65
  6. McEvoy JP, Lieberman JA, Stroup TS, Davis SM, Meltzer HY, Rosenheck RA. et al. Effectiveness of clozapine versus olanzapine, quetiapine, and risperidone in patients with chronic schizophrenia who did not respond to prior atypical antipsychotic treatment. Am J Psychiatry 2006;163(4):600-10
  7. Niemine-von Wendt TS, Metsahonkala L, Kulomaki TA, Aalto S, Autti TH, Vanhala R. et al. Increased presynaptic dopamine function in Asperger syndrome. NeuroReport 2004;15(5): 757-60
  8. Krakowski MI, Czobor P, Citrome L, Bark N, Cooper TB. Atypical antipsychotic agents in the treatment of violent patients with schizophrenia and schizoaffective disorder. Arch Gen Psychiatry 2006;63(6):622-9.