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Journals / Klinik Psikofarmakoloji Bülteni / 2012 / Cilt: 22 - Sayı: 3

Restless Legs Syndrome in an Elderly Patient Induced by Combined Use of Low Dose Quetiapine and Citalopram

Yaşlı bir hastada düşük doz ketiapin ve sitalopram kombinasyonuna bağlı huzursuz bacaklar sendromu

Şadiye Visal BUTURAK
Aylin Ertekin YAZICI
Ayşe BAŞTERZİ DEVRİM
Şenel TOT
Kemal YAZICI
Pages
271–273
Publication Date
2022-10-17
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Dopaminergic dysfunction and achange in the regulation of iron homeostasis leading toiron depletion in the central nervous system (CNS) arethought to be involved in the pathophysiology of RLS.The aim of this paper is to point out the side effectswith off-label use of antipsychotics and call attention tooften overlooked RLS by describing an elderly patientwho developed RLS symptoms after addition of 50mg/d quetiapine to preexisting 20 mg/d citalopramtreatment.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Restless legs syndrome (RLS) is a relatively commonsensory-motor disorder.
📊
Key Findings & Data:However, it is frequentlyunrecognized.
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Conclusion & Impact:Dopaminergic dysfunction and achange in the regulation of iron homeostasis leading toiron depletion in the central nervous system (CNS) arethought to be involved in the pathophysiology of RLS.The aim of this paper is to point out the side effectswith off-label use of antipsychotics and call attention tooften overlooked RLS by describing an elderly patientwho developed RLS symptoms after addition of 50mg/d quetiapine to preexisting 20 mg/d citalopramtreatment.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Restless legs syndrome (RLS) is a relatively commonsensory-motor disorder. However, it is frequentlyunrecognized. The main clinical characteristics ofRLS are “an urge to move” and “uncomfortable andunpleasant sensations” in the legs, which can affectquality of daily life and sleep. The diagnosis is based onclinical findings. Polysomnography can reveal its impacton sleep physiology. Dopaminergic dysfunction and achange in the regulation of iron homeostasis leading toiron depletion in the central nervous system (CNS) arethought to be involved in the pathophysiology of RLS.The aim of this paper is to point out the side effectswith off-label use of antipsychotics and call attention tooften overlooked RLS by describing an elderly patientwho developed RLS symptoms after addition of 50mg/d quetiapine to preexisting 20 mg/d citalopramtreatment.

Özet

Huzursuz bacaklar sendromu (HBS) nispeten sık görülen ancak sıklıkla tanınmayan ve etyolojisi bilinmeyen duyusal-motor bozukluktur. HBS’nin temel klinik belirtisi hastaların bacaklarında ortaya çıkan, günlük yaşam ve uyku kalitesini etkileyebilen, “hareket ettirme dürtüsü” ve “hoş olmayan hisler”dir. HBS’nin tanısı klinik bulgulara dayanılarak konulur. Polisomniografi, rahatsızlığın uyku fizyolojisi üzerindeki etkilerini göstermede faydalı olabilir. Merkezi sinir sistemindeki (MSS) dopaminerjik bir disfonksiyonun veya bir demir hemostazında deplesyona yol açacak bir değişikliğin, HBS’nin fizyopatolojisinde etkili olabileceği düşünülmektedir. Bu makalede, 20mg/gün dozunda sitalopram tedavisine 50 mg/gün dozunda ketiapin eklenmesinden sonra HBS semptomları geliştiren yaşlı bir erkek hastanın klinik tablosu tanımlanarak, genellikle gözden kaçırılan HBS‘ye ve antipsikotiklerin normal endikasyonları dışında kullanımları esnasında ortaya çıkabilecek yan etkilere dikkat çekilmesi amaçlanmıştır.

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Cite This Article

BUTURAK, Ş. V., YAZICI, A. E., DEVRİM, A. B., TOT, Ş., YAZICI, K. (2022). Restless Legs Syndrome in an Elderly Patient Induced by Combined Use of Low Dose Quetiapine and Citalopram. Klinik Psikofarmakoloji Bülteni, Cilt: 22 - Sayı: 3, 271–273. https://ajindex.com/articles/574134

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