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Journals / Klinik Psikofarmakoloji Bülteni / 2016 / Cilt: 26 - Sayı: 1

Association of the Neuropeptide Y LEU7PRO rs16139 and NEUREXIN 3 rs760288 polymorphisms with alcohol dependence

Cem SENGUL
Mehmet Emin ERDAL
Ceyhan Balci SENGUL
Ozlem Izci AY
Ahmet BUBER
Huseyin ALACAM
Mustafa Ertan AY
Hasan HERKEN
Pages
15–20
Publication Date
2022-10-17
DOI
—
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Conclusions: Neurexin gene polymorphisms might be an important factor in development of alcohol addiction.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Alcoholism is associated with genetic variants of genes related to alcohol metabolizing enzymes, dopaminergic, gamma-aminobutyric acidergic, glutamatergic, opioid, cholinergic, and serotonergic systems.
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Key Findings & Data:In the present study, we aimed to investigate the association of Neurpeptide Y LEU7PRO rs16139 and neurexin 3 gene rs760288 polymorphisms with alcohol dependence in patients with alcohol dependence and healthy control subjects.
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Conclusion & Impact:Conclusions: Neurexin gene polymorphisms might be an important factor in development of alcohol addiction.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Alcoholism is associated with genetic variants of genes related to alcohol metabolizing enzymes, dopaminergic, gamma-aminobutyric acidergic, glutamatergic, opioid, cholinergic, and serotonergic systems. Neurpeptide Y system and Neurexins were shown to be associated with alcohol dependence. Recent studies identified new genetic polymorphisms related to endogenous cannabinoid system, neuropetide Y and neurexin. In the present study, we aimed to investigate the association of Neurpeptide Y LEU7PRO rs16139 and neurexin 3 gene rs760288 polymorphisms with alcohol dependence in patients with alcohol dependence and healthy control subjects. Methods: 123 patients who were diagnosed with alcohol dependence according to the DSM-IV criteria and 159 healthy volunteers were included in the study. Blood samples were used to investigate polymorphisms. The genotyping of the neurexin 3 gene rs760288 and the neuropetide Y gene Leu7Pro rs16139 polymorphisms was performed using TaqMan SNP Genotyping Assays Real-Time PCR System. Results: Of the 2 genetic polymorphisms investigated in the present study, we detected association between and neurexin 3 gene rs760288 polymorphisms with alcohol dependence. Conclusions: Neurexin gene polymorphisms might be an important factor in development of alcohol addiction.

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Cite This Article

SENGUL, C., ERDAL, M. E., SENGUL, C. B., AY, O. I., BUBER, A., ALACAM, H., AY, M. E., HERKEN, H. (2022). Association of the Neuropeptide Y LEU7PRO rs16139 and NEUREXIN 3 rs760288 polymorphisms with alcohol dependence. Klinik Psikofarmakoloji Bülteni, Cilt: 26 - Sayı: 1, 15–20. https://ajindex.com/articles/573915

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