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Journals / Klinik Psikiyatri Dergisi / 2021 / Cilt: 24 - Sayı: 2

Ischemia modified albumin: A potentialmarker for global metabolic risk in genera lized anxiety disorder and panic disorder

İskemi modifiye albumin: Yaygın anksiyete bozukluğu ve panik bozuklukta ki genel metabolik risk için potansiyel bir belirteç

Murat İlhan ATAGÜN
Salim NEŞELİOĞLU
Esra KABADAYI ŞAHİN
Gökçen TURAN
Pages
153–159
Publication Date
2022-10-17
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The GAD and PD groups had sig nificantly higher serum IMA levels than healthy controls(p

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Ischemia modified albumin (IMA) is analtered type of albumin produced due to exposure tohypoxia, acidosis, inflammation, or oxidative stress.
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Key Findings & Data:Inthis study, we aimed to evaluate the serum IMA levels innewly diagnosed and medication-naive generalized an xiety disorder (GAD) and panic disorder (PD) patients.Method: This cross-sectional study included medication naive 23 GAD, 25 PD patients, and 28 healthy controls.The participants were evaluated with a sociodemograp hic form, the Beck Depression Inventory (BDI), and theBeck Anxiety Inventory (BAI).
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Conclusion & Impact:The GAD and PD groups had sig nificantly higher serum IMA levels than healthy controls(p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Ischemia modified albumin (IMA) is analtered type of albumin produced due to exposure tohypoxia, acidosis, inflammation, or oxidative stress. Inthis study, we aimed to evaluate the serum IMA levels innewly diagnosed and medication-naive generalized an xiety disorder (GAD) and panic disorder (PD) patients.Method: This cross-sectional study included medication naive 23 GAD, 25 PD patients, and 28 healthy controls.The participants were evaluated with a sociodemograp hic form, the Beck Depression Inventory (BDI), and theBeck Anxiety Inventory (BAI). Venous blood sampleswere collected from all participants, and IMA levels androutine biochemical parameters were measured.Results: There was no statistically significant differencebetween three groups in terms of age, gender, bodymass index (BMI) and routine biochemical markers of theparticipants (p>0.05). The GAD and PD groups had sig nificantly higher serum IMA levels than healthy controls(p

Özet

Amaç: İskemi modifiye albümin (İMA), hipoksi, asidoz,inflamasyon, oksidatif stres sonucu üretilen modifiye biralbümin türüdür. Bu çalışmada, yeni tanı alan ve dahaönce ilaç kullanmamış yaygın anksiyete bozukluğu (YAB)ve panik bozukluk (PB) hastalarında serum İMA düzey lerinin değerlendirilmesi amaçlanmıştır. Yöntem: Bukesitsel çalışmaya, daha önce ilaç kullanmamış 23 YAB,25 PB hastası ve 28 sağlıklı kontrol dahil edildi.Katılımcılar sosyodemografik veri formu, Beck DepresyonÖlçeği (BDÖ) ve Beck Anksiyete Ölçeği (BAÖ) iledeğerlendirildi. Tüm katılımcıların serum İMA düzeylerive rutin biyokimyasal parametreleri ölçüldü. Bulgular:Katılımcıların yaş, cinsiyet, vücut kitle indeksi (VKİ) vebiyokimyasal belirteçleri açısından gruplar arasındaistatistiksel olarak anlamlı fark yoktu (p> 0.05). SerumİMA düzeyleri YAB ve PB gruplarında sağlıklı kontrolleregöre anlamlı olarak daha yüksekken (p

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Cite This Article

ATAGÜN, M. İ., NEŞELİOĞLU, S., ŞAHİN, E. K., TURAN, G. (2022). Ischemia modified albumin: A potentialmarker for global metabolic risk in genera lized anxiety disorder and panic disorder. Klinik Psikiyatri Dergisi, Cilt: 24 - Sayı: 2, 153–159. https://ajindex.com/articles/573828

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References (14)

  1. Wittchen HU, Jacobi F, Rehm J, Gustavsson A, Svensson M, Jönsson B, Olesen J, Allgulander C, Alonso J, Faravelli C, Fratiglioni L. The size and burden of mental disorders and other disorders of the brain in Europe 2010. Eur Neuropsychopharmacol 2011;21:655-79
  2. Tyrer P, Baldwin D. Generalised anxiety disorder. Lancet 2006;368:2156–66
  3. Freire R, Zugliani M, Garcia R, Nardi A. Treatment–resistant panic disorder: a systematic review. Expert Opin Pharmacother 2016;17:159–68
  4. Bouayed J, Rammal H, Soulimani R. Oxidative stress and anxiety: relationship and cellular pathways. Oxid Med Cell Longev 2009;2:63–7
  5. Vogelzangs N, Beekman A, De Jonge P, Penninx B. Anxiety disorders and inflammation in a large adult cohort. Transl Psychiatry 2013;3:249
  6. Liguori I, Russo G, Curcio F, Bulli G, Aran L, Della-Morte D, Gargiulo G, Testa G, Cacciatore F, Bonaduce D, Abete P. Oxidative stress, aging, and diseases. Clin Interv Aging 2018;13:757
  7. Reyazuddin M, Azmi S, Islam N, Rizvi A. Oxidative stress and level of antioxidant enzymes in drug-naive schizophrenics. Indian J Psychiatry 2014;56:344
  8. Smaga I, Niedzielska E, Gawlik M, Moniczewski A, Krzek J, Pera J, Filip M. Pharmacological Reports Oxidative stress as an etiological factor and a potential treatment target of psychiatric disorders. Part 2. Depression, anxiety, schizophrenia and autism. Pharmacol reports 2015;67:569–80
  9. Savas H, Gergerlioglu H, Armutcu F, Herken H, Yilmaz H, Kocoglu E. Elevated serum nitric oxide and superoxide dismutase in euthymic bipolar patients: impact of past episodes. World J Biol Psychiatry 2006;7:51–5
  10. Sbarouni E, Georgiadou P, Voudris V. Ischemia modified albumin changes - review and clinical implications. Clin Chem Lab Med 2011;49:177–84
  11. Bar-Or D, Curtis G, Rao N, Bampos N, Lau E. Characterization of the Co(2+) and Ni(2+) binding amino-acid residues of the N-terminus of human albumin. Eur J Biochem. 2001;268:42–7
  12. Roy D, Quiles J, Gaze D, Collinson P, Kaski J, Baxter G. Role of reactive oxygen species on the formation of the novel diagnostic marker ischaemia modified albumin. Heart 2006;92:113–4
  13. Bar-Or D, Lau E, Winkler J. A novel assay for cobalt-albumin binding and its potential as a marker for myocardial ischemia-a preliminary report. J Emerg Med 2000;19:311–5
  14. Turan T, Akyüz A, Sahin S, Kul S, Yilmaz A, Kara F, Mentese SO, Aykan AÇ, Demir SE, Celik S, Karahan SC. Association between the plasma levels of IMA and coronary atheroscleroti