Importance of transition zone PSA density for the diagnosis of prostate cancer

Objective & Hypothesis:In this study, we investigated whether transition zone PSA density could be an adjunct in the diagnosis of prostate cancer and avoid unnecessary prostate biopsies.

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Key Findings & Data:Between November 2002-March 2003,50 patients with lower urinary tract complaints and known plasma PS A levels were included in the study.

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Conclusion & Impact:PSA-TZ, which shows high sensitivity and specificity values, could be used for diagnosis of prostate cancer and helps avoiding unnecessary biopsies.

🔬Design:Research Article

📍Scope:2002 Verileri

⚙️Variables:Domain Parameters

Abstract

In this study, we investigated whether transition zone PSA density could be an adjunct in the diagnosis of prostate cancer and avoid unnecessary prostate biopsies. Between November 2002-March 2003,50 patients with lower urinary tract complaints and known plasma PS A levels were included in the study. Transrectal ultrasound guided sextant biopsies with two additional transition zone (TZ) biopsies were performed. Total PSA (tPSA), PSA density (PSAD), PSA density of transition zone (PSAD-TZ) and free/total PSA (f/t PSA) levels of the patients were measured and calculated. Of 50 patients, 37 had histologically benign and 13 malignant results. Sensitivity of the tPSA, PSAD and f/t PSAD were found 92.3%, 76.9% and 50%; and specificity 15.6%, 59.25% and 46.6%, respectively. Sensitivity and specificity of the PSAD-TZ were 67.5% and 69.2%, respectively. PSA-TZ, which shows high sensitivity and specificity values, could be used for diagnosis of prostate cancer and helps avoiding unnecessary biopsies.

Özet

Çalışmamızda transizyonel zon PSA dansitesinin (PSAD-TZ) prostat kanserinin tanısında ve gereksiz prostat biyopsilerinden kaçınmada kullanılabilirliğini araştırdık. Kasım 2002-Mart 2003 tarihleri arasında alt üriner sistem şikayetleri olan ve serum PSA seviyeleri bilinen 50 hasta çalışmaya alınmıştır. Tüm hastalara transrektal ultrasonografi (TRUS) eşliğinde 6 kadran biyopsiye ilave olarak bilateral transizyonel zon (TZ) biyopsileri uygulanmıştır. Olguların total PSA (tPSA), PSA dansitesi (PSAD), PSAD-TZ ve serbest/total PSA (s/t PSA) değerleri tespit edilmiştir. Histopatolojik inceleme sonucunda olguların 37'si benign, 13 "ü de malign olarak rapor edilmiştir. tPSA, PSAD ve s/t PSA'mn duyarlılık değerleri sırasıyla %92,3, %76,9 ve %50; özgüllük değerleri ise %15.6, %59,25 ve %46.6 olarak bulunmuştu-. PSAD-TZ'nin özgüllük değeri %67,5, duyarlılık değeri %69,2 olarak tespit edilmiştir. Gerek özgüllük değeri ve gerekse duyarlılık değeri yüksek bulunan PSAD-TZ, prostat karsinomu tanısı ve gereksiz biyopsilerden kaçınmada kullanılabilir bir parametredir.

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Cite This Article

TARHAN, F., BARIŞIK, C. C., BENEK, Y. Z., YILDIZ, A. C., BARIŞIK, Ö. N., SUNGURLU, F. (2022). Importance of transition zone PSA density for the diagnosis of prostate cancer. Kartal Eğitim ve Araştırma Hastanesi Tıp Dergisi, Cilt: 14 - Sayı: 3, 153–155. https://ajindex.com/articles/571580

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