SavedAdd your journal

Journals / Kartal Eğitim ve Araştırma Hastanesi Tıp Dergisi / 2015 / Cilt: 26 - Sayı: 2

The Importance of Pregnancy-associated Plasma Protein-A Level for the Prediction of Preeclampsia

Gebelikle İlişkili Plazma Protein-A Değerinin Preeklampsi Öngörüsündeki Önemi

Cihan İNAN
Halenur BOZDAĞ
Erhan KARAALP
Erdem BAŞKENT
Meriç Çağrı AĞIR
Pages
115–121
Publication Date
2022-10-17
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Results: The PAPP-A multiple of the median (MoM) level in thepreeclampsia group was significantly decreased (MoM=0.76,p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Background: The aim of this study was to identfy the predic- tive value of maternal pregnancy-associated plasma protein-A(PAPP-A) levels as a predictor of risk of preeclampsia.
📊
Key Findings & Data:Methods: Maternal serum PAPP-A levels in the first trimesterfrom 53 singleton pregnancies developed preeclampsia, and53 normotensive singleton pregnancies were identified.
💡
Conclusion & Impact:Results: The PAPP-A multiple of the median (MoM) level in thepreeclampsia group was significantly decreased (MoM=0.76,p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background: The aim of this study was to identfy the predic- tive value of maternal pregnancy-associated plasma protein-A(PAPP-A) levels as a predictor of risk of preeclampsia. Methods: Maternal serum PAPP-A levels in the first trimesterfrom 53 singleton pregnancies developed preeclampsia, and53 normotensive singleton pregnancies were identified. Theassociation between PAPP-A levels and the incidence of pre- eclampsia was investigated by determining a cut-off value. Results: The PAPP-A multiple of the median (MoM) level in thepreeclampsia group was significantly decreased (MoM=0.76,p

Özet

Amaç: Gebelikte gebelikle ilişkili plazma protein-A (PAPP-A)düzeyinin preeklampsi öngörüsünde kullanılabilirliğini be- lirlemek bu çalışmanın temel amacıdır. Gereç ve Yöntem: Preeklampsi gelişen 53 gebe ve normo- tansif olan 50 gebenin birinci trimestr maternal serumPAPP-A MoM düzeyleri belirlendi. PAPP-A için kestirim de- ğeri belirlenerek PAPP-A ve preeklampsi insidansı arasındakiilişki ortaya konulmaya çalışıldı. Bulgular: Preeklampsi gelişen grupta PAPP-A değerininanlamlı bir şekilde daha düşük olduğu görüldü (0.76 MoM,p

🔖

Cite This Article

İNAN, C., BOZDAĞ, H., KARAALP, E., BAŞKENT, E., AĞIR, M. Ç. (2022). The Importance of Pregnancy-associated Plasma Protein-A Level for the Prediction of Preeclampsia. Kartal Eğitim ve Araştırma Hastanesi Tıp Dergisi, Cilt: 26 - Sayı: 2, 115–121. https://ajindex.com/articles/571335

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (13)

  1. Dekker G, Sibai B. Primary, secondary, and tertiary pre- vention of pre-eclampsia. Lancet 2001;357(9251):209– 15
  2. Özdemir İ, Gül ÖK, Yücel O. Preeklampsi, eklampsi ve HELLP sendromunda maternal morbidite ve mortalite nedenleri. Düzce Tıp Fakültesi Dergisi 2003;3(1):5–9
  3. Berg CJ, Harper MA, Atkinson SM, Bell EA, Brown HL, Hage ML, et al. Preventability of pregnancy-related deaths: results of a state-wide review. Obstet Gynecol 2005;106(6):1228–34
  4. Lin TM, Galbert SP, Kiefer D, Spellacy WN, Gall S. Charac- terization of four human pregnancy-associated plasma proteins. Am J Obstet Gynecol 1974;118(2):223–36
  5. Hughes G, Bischof P, Wilson G, Klopper A. Assay of a placental protein to determine fetal risk. Br Med J 1980;280(6215):671–3
  6. Consuegra-Sanchez L, Fredericks S, Kaski JC. Pregnancy- associated plasma protein A: Has this biomarker crossed the boundary from research to clinical practice? Drug News Perspect 2009;22(6):341–8
  7. Barnea ER, Bischoff P, Page C, DeCherney AH, Herrmann W, Naftolin F. Placental and circulating pregnancy- associated plasma protein A concentrates in normal and pathological term pregnancies. Obstet Gynecol 1986;68(3):382–6
  8. Meloni P, D’Angeli I, Piazze J, Cerekya A, Simari T, Pala A, et al. First trimester PAPP-A levels associated with early prediction of pregnancy induced hypertension. Hyper- tens Pregnancy 2009;28(4):361–8
  9. Pilalis A, Souka AP, Antsaklis P, Daskalakis G, Papanto- niou N, Mesogitis S, et al. Screening for pre-eclampsia and fetal growth restriction by uterine artery Doppler and PAPP-A at 11-14 weeks’ gestation. Ultrasound Ob- stet Gynecol 2007;29(2):135–40
  10. Spencer K, Cowans NJ, Nicolaides KH. Low levels of ma- ternal serum PAPP-A in the first trimester and the risk of pre-eclampsia. Prenat Diagn 2008;28(1):7–10
  11. Huang T, Hoffman B, Meschino W, Kingdom J, Okun N. Prediction of adverse pregnancy outcomes by combina- tions of first and second trimester biochemistry markers used in the routine prenatal screening of Down syn- drome. Prenat Diagn 2010;30(5):471–7
  12. Spencer K, Cowans NJ, Chefetz I, Tal J, Meiri H. First- trimester maternal serum PP-13, PAPP-A and second- trimester uterine artery Doppler pulsatility index as markers of pre-eclampsia. Ultrasound Obstet Gynecol 2007;29(2):128–34
  13. Goetzinger KR, Singla A, Gerkowicz S, Dicke JM, Gray DL, Odibo AO. Predicting the risk of pre-eclampsia between 11 and 13 weeks’ gestation by combining maternal char- acteristics and serum anal