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Journals / Kartal Eğitim ve Araştırma Hastanesi Tıp Dergisi / 2016 / Cilt: 27 - Sayı: 3

Klinefelter Sendromu ve Kötü Kontrollü Diyabeti Olan Bir Olguda Androjen Replasman Tedavisinin Kan Şekeri Regülasyonu Üzerine Etkileri

The Effects of Androgen Replacement Therapy on Glycemic Control in a Case with Klinefelter Syndrome and Poorly Controlled Diabetes

Ayşenur ÖZDERYA
Şule TEMİZKAN
Kadriye AYDIN TEZCAN
Pages
227–232
Publication Date
2022-10-17
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Testosterone replacement therapy can improve glycemic control in these patients

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Klinefelter syndrome (KS) is the most common sex chromosome anomaly among men.
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Key Findings & Data:It is usually characterized by hypergonadotropic hypogonadism, eunuchoid body structure, and most often, 47,XXY karyotype.
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Conclusion & Impact:Testosterone replacement therapy can improve glycemic control in these patients
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Klinefelter syndrome (KS) is the most common sex chromosome anomaly among men. It is usually characterized by hypergonadotropic hypogonadism, eunuchoid body structure, and most often, 47,XXY karyotype. Studies have shown that KS patients have high risk of developing autoimmune diseases and diabetes, and the hypogonadism that accompanies the syndrome makes regulation of diabetes more difficult. A 39-year-old man with KS was admitted to Endocrinology and Metabolic Diseases Polyclinic because of increased blood glucose level: His glycated hemoglobin (HbA1c) value was 14.9%. He had diabetes for approximately 5 years and was using 80 IU insulin daily at time of admission, but after testosterone replacement therapy, his insulin requirement decreased to 60 units. Follow-up HbA1c was 7.7% after 2 months of androgen replacement therapy. Hypoandrogenemia may contribute to development of newly diagnosed diabetes or deterioration of pre-existing diabetes. Testosterone replacement therapy can improve glycemic control in these patients

Özet

Hipergonadotropik hipogonadizm ve önikoid vücut yapısı ile karakterize olan Klinefelter sendromu (KS), erkeklerde en sık rastlanan seks kromozom anomalisi olup, genellikle 47,XXY karyotipine sahiptir. Klinefelter sendromunda, otoimmün hastalık ve diyabet gelişme riskinin yüksek olduğu ve eşlik eden hipoandrojeneminin diyabet regülasyonunu kötüleştirdiği çalışmalarda gösterilmiştir. Otuz dokuz yaşındaki erkek hasta, kan şekeri yüksekliği nedeniyle endokrinoloji ve metabolizma hastalıkları polikliniğine başvurdu. Yaklaşık beş yıldır diyabet tanısı olan hastanın HbA1c değeri %14.9 olarak belirlendi. Başvuru sırasında günlük yaklaşık 80 ünite insülin kullanan hastanın androjen replasman tedavisi sonrası insülin ihtiyacı yaklaşık 60 üniteye kadar geriledi. Takiplerinde, androjen replasman tedavisi başlandıktan iki ay sonraki kontrol HbA1c değeri %7.7 olarak belirlendi. Hipoandrojenemi diyabet gelişimi ve mevcut diyabetin regülasyonunda bozulmaya sebep olmaktadır. Bu hastalarda testosteron replasmanı, glisemik kontrolü düzeltebilir

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Cite This Article

ÖZDERYA, A., TEMİZKAN, Ş., TEZCAN, K. A. (2022). Klinefelter Sendromu ve Kötü Kontrollü Diyabeti Olan Bir Olguda Androjen Replasman Tedavisinin Kan Şekeri Regülasyonu Üzerine Etkileri. Kartal Eğitim ve Araştırma Hastanesi Tıp Dergisi, Cilt: 27 - Sayı: 3, 227–232. https://ajindex.com/articles/571256

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