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Journals / Kafkas Üniversitesi Veteriner Fakültesi Dergisi / 2021 / Cilt: 27 - Sayı: 3

Association of BMPR-1B Gene 3’-UTR Region Polymorphism with Litter Size in Tibetan Sheep

Tibet Koyunlarında BMPR-1B Geni 3’-UTR Bölgesi Polimorfizmi İle Batın Genişliği İlişkisi

Jianlei JIA
Dejuan XIE
Yingying ZHANG
Huaixia ZHANG
Liping ZHANG
Shengzhen HOU
Qian CHEN
Pages
285–289
Publication Date
2022-10-17
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The χ2 independence test analyses indicatedthat the A1354G variant of BMPR-1B gene 3’UTR region polymorphisms was signifi cantly correlated with litter size in all-types Tibetan sheep (P

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Bone Morphogenetic Protein Receptor-1B (BMPR-1B) is considered as the primary gene in sheep for follicular development and litter size trait.
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Key Findings & Data:Ithas been defi ned as the most major candidate gene for genetic markers of sheep reproductive performance.
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Conclusion & Impact:The χ2 independence test analyses indicatedthat the A1354G variant of BMPR-1B gene 3’UTR region polymorphisms was signifi cantly correlated with litter size in all-types Tibetan sheep (P
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Bone Morphogenetic Protein Receptor-1B (BMPR-1B) is considered as the primary gene in sheep for follicular development and litter size trait. Ithas been defi ned as the most major candidate gene for genetic markers of sheep reproductive performance. In our study, polymorphisms in theBMPR-1B gene 3’-UTR region were investigated in 363 Tibetan sheep (119 Plateau-type Tibetan sheep, 141 Valley-type Tibetan sheep, and 103Oula-type Tibetan sheep) by DNA sequencing analysis. Two single nucleotide polymorphisms (SNPs) were identifi ed, which were G1339A andA1354G. The frequencies of SNPs were in Hardy-Weinberg equilibrium (Chi-square test, P>0.05). AA and AG genotypes were found in the A1354Gvariant of the 3’UTR region, that AA and A were the preponderant genotype and allele, respectively. The χ2 independence test analyses indicatedthat the A1354G variant of BMPR-1B gene 3’UTR region polymorphisms was signifi cantly correlated with litter size in all-types Tibetan sheep (P

Özet

Kemik Morfogenetik Protein Reseptörü-1B (BMPR-1B), koyunlarda foliküler gelişim ve batın genişliği özelliği için birincil gen olarak kabul edilir. Bu gen, koyunlarda üreme performansının genetik belirteçleri için en önemli aday gen olarak tanımlanmıştır. Çalışmamızda, 363 Tibet koyununda (119 plato tipi Tibet koyunu, 141 vadi tipi Tibet koyunu ve 103 Oula tipi Tibet koyunu) BMPR-1B geninin 3’-UTR bölgesindeki polimorfi zmler DNA dizi analizi ile araştırıldı. G1339A ve A1354G adlı iki single nükleotid polimorfi zm (SNP) saptandı. SNP’lerin frekansları Hardy-Weinberg dengesi içerisindeydi (Ki-kare testi, P>0.05). 3’UTR bölgesinin A1354G varyantında AA ve AG genotipleri saptandı ve AA ve A sırasıyla baskın genotip ve aleldi. χ2 bağımsızlık testi analizleri, BMPR-1B geni 3’UTR bölgesi polimorfi zmlerinden A1354G varyantının, tüm Tibet koyun türlerinde batın genişliği ile yakından ilişkili olduğunu gösterdi (P

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Cite This Article

JIA, J., XIE, D., ZHANG, Y., ZHANG, H., ZHANG, L., HOU, S., CHEN, Q. (2022). Association of BMPR-1B Gene 3’-UTR Region Polymorphism with Litter Size in Tibetan Sheep. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, Cilt: 27 - Sayı: 3, 285–289. https://ajindex.com/articles/569848

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References (1)

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