Journals / Cukurova Medical Journal / 2014 / Cilt: 39 - Sayı: 4

The Clinicopathological Study of Lupus Nephritis

Lupus Nefritinin Klinikopatolojik Çalışması

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Publication Date
2014-07-22
DOI
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Conclusion: Males had more severe type of lupus nephritis than females.

📌 3 Key Takeaways

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Objective & Hypothesis:Purpose: Lupus nephritis is one of the most serious manifestations of Systemic lupus erythematosis and it is a major cause of morbidity and mortality.
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Key Findings & Data:Material and Methods: A cross-sectional study performed on forty five patients with biopsy proven Lupus Nephritis including 32 females and 13 males.
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Conclusion & Impact:Conclusion: Males had more severe type of lupus nephritis than females.
🔬Design:Survey & Empirical Study
📍Scope:Comprehensive Sample
⚙️Variables:Sistemik lupuseritematozus · Lupus nefriti · cinsiyet

Abstract

Purpose: Lupus nephritis is one of the most serious manifestations of Systemic lupus erythematosis and it is a major cause of morbidity and mortality. The aim of this study is to compare males and females in lupus nephritis presentations. Material and Methods: A cross-sectional study performed on forty five patients with biopsy proven Lupus Nephritis including 32 females and 13 males. All patients assessed by questionnaire form and investigated for hematological, biochemical, immunological, serological, urinalysis, and 24hrs urinary protein excretion. Results: The current study shows female predominance 32(71.1%) compared with 13(28.9%) male. Class IV 15(33.3%) nephritis was the most common type followed by class III 9(20.9%).The male patients develop nephritis early in the course of Systemic lupus erythematosis than females, and they were more commonly had hypertension and edema, and the hematological, cardiovascular, pulmonary, and central nervous system were the most common extra renal manifestation in males while mucocutaneous manifestations were the commonest in females, and further more males had more proliferative type of Lupus nephritis than females. Conclusion: Males had more severe type of lupus nephritis than females.

Özet

Amaç:Lupus nefriti sistemik lupuseritematozusun en ciddi belirtilerinden biridir ve morbidite ve mortalitenin esas sebebidir. Bu çalışmanın amacı lupus nefriti olgularında erkek ve kadınlar arasında karşılaştırma yapmaktır. Materyal ve Metod:Biyopsi ile Lupus nefriti olduğu kanıtlanmış 45 hasta (32 kadın, 13 erkek) üzerinde kesitsel çalışma uygulandı. Tüm hastalara anket yapıldı. Hastalara biyokimyasal, immünolojik, serolojik, hematolojik tetkikler ve idrar tahlili yapıldı. 24 saatlik idrarda protein atılımına bakıldı. Bulgular:Yapılan çalışmaya göre kadınların (32, %71.1) erkeklere (13, %28.9) nazaran daha baskın olduğu görülmüştür. En yaygın tip olarak 4. sınıf nefriti (15, %33.3) sonrasında ise 3. sınıf nefriti (9, %20.9) görülmüştür.Sistemik lupuseritematozuslu erkek hastalar, kadınlardan daha erken bir dönemde nefriti geliştirmişlerdir.Erkeklerde daha yaygın hipertansiyon ve ödem vardı.Kadınlarda böbrek dışında en yaygın belirti mukokutanöziken erkeklerdehematolojik, kardiyovasküler, solunum ve merkezi sinir sistemi manifestasyonu görülür.Kadınlara nazaran erkeklerde daha fazla proliferatif tipte lupus nefriti gözlenmiştir. Sonuç:Erkeklerde kadınlara nazaran daha ciddi tipte lupus nefriti görülmüştür.

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Cite This Article

MERZA, R. R., ALİ, A. O., KHAN, H. A. E. K. (2014). The Clinicopathological Study of Lupus Nephritis. Cukurova Medical Journal, Cilt: 39 - Sayı: 4, 0. https://ajindex.com/articles/56913

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