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Journals / Journal of the Turkish-German Gynecological Association / 2005 / Cilt: 6 - Sayı: 2

Büyük jinekolojik operasyonlarda profilatik antiemetik tedavi olarak intravenöz ondansetron infüzyonu ve dil üstü hızlı çözünen ondansetron tabletin etkinlik ve maliyet açısından karşılaştırılması

Comparison of costs and efficacy of intravenous and orally disintegrating ondansetron tablet as a prophylactic antiemetic therapy in major gynecologic operations

İsmail ÖZDEMİR
Buket KOCAMAN
Fuat DEMİRCİ
Feray HAYIT
Yavuz DEMİRARAN
Pages
134–138
Publication Date
2022-10-18
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The incidence rates of nausea, vomiting and the need of metoclopropamide were higher in placebo group than intravenous and oral ondansetron groups (P

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The aim of the study is to compare the antiemetic efficacy and costs of oral rapid disintegrating ondansetron tab¬lets and intravenously administered ondansetron in patients undergoing major gynecologic surgery.
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Key Findings & Data:Patients were prospectively randomized into three groups of 30 patients each, receiv¬ing either ondansetron 8 mg intravenously or saline infusion only or oral rapid disintegrating tablets of 8 mg ondansetron.
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Conclusion & Impact:The incidence rates of nausea, vomiting and the need of metoclopropamide were higher in placebo group than intravenous and oral ondansetron groups (P
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: The aim of the study is to compare the antiemetic efficacy and costs of oral rapid disintegrating ondansetron tab¬lets and intravenously administered ondansetron in patients undergoing major gynecologic surgery. Materials and Methods: Anesthesia was induced with thiopenthone, vecuronium and fentanyl. Nitrous oxide and sevoflu-rane were used to maintain anesthesia. Patients were prospectively randomized into three groups of 30 patients each, receiv¬ing either ondansetron 8 mg intravenously or saline infusion only or oral rapid disintegrating tablets of 8 mg ondansetron. The patients were evaluated for nausea and vomiting at 1st, 5th, 10th, 20th, 30th, 60th, and 120th minutes and 6th hours posto-peratively. Results: There were no significant differences in adverse effects between placebo group, intravenous ondansetron group and oral ondansetron group (P>0.05). The incidence rates of nausea, vomiting and the need of metoclopropamide were higher in placebo group than intravenous and oral ondansetron groups (P

Özet

Amaç: Çalışmanın amacı, majör jinekolojik operasyon yapılan hastalarda, hızlı çözünen oral ondansetron tablet ile intrave-nöz ondansetron infüzyonunun antiemetik etkinliklerini ve maliyetlerini karşılaştırmaktır. Materyal ve Metot: Anestezi indüksiyonu pentotal, vekuronyum ve fentanil ile yapıldı. Azot protoksit ve sevofloran idame olarak verildi. Hastalar prospektif olarak, yalnız 8 mg ondansetron infüzyonu alan veya yalnız izotonik infüzyonu alan ya da oral hızlı çözünen 8 mg ondansetron içeren tablet alan her biri 30'ar denek içeren üç gruba ayrıldılar. Ameliyattan sonraki 1., 5., 10., 20., 30., 60., 120. dakikalarda ve 6. saatte hastalar bulantı ve kusma şikâyetleri açısından değerlendirilirdi. Sonuçlar: Plasebo, intravenöz ondansetron ve oral ondansetron grupları arasında yan etkiler açısından anlamlı fark bulun¬madı. Bulantı, kusma ve metoklopropamid ihtiyacı plasebo grubunda oral ve intravenöz ondansetron gruplarına göre istatis¬tiksel olarak daha yüksek orandaydı (P

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Cite This Article

ÖZDEMİR, İ., KOCAMAN, B., DEMİRCİ, F., HAYIT, F., DEMİRARAN, Y. (2022). Büyük jinekolojik operasyonlarda profilatik antiemetik tedavi olarak intravenöz ondansetron infüzyonu ve dil üstü hızlı çözünen ondansetron tabletin etkinlik ve maliyet açısından karşılaştırılması. Journal of the Turkish-German Gynecological Association, Cilt: 6 - Sayı: 2, 134–138. https://ajindex.com/articles/568028

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References (13)

  1. Watcha MF, White PF. Postoperative Nausea and Vomiting-do they matter? Eur J Anaesthesiol 1995;12:18-23
  2. Larsson S, Lundberg D. A prospective survey of postoperative nausea and vomiting with special regard to incidence and relations to patient characteristics, anaesthetic routines and surgical procedures. Acta Anaesthesiol Scand 1995;39:539-45
  3. Kenny GN. Risk factors for postoperative nausea and vomiting. Anaesthesia 1994;49:6-10
  4. Cohen MM, Duncan PG, De Boer DP, Tweed WA. The postoperative interview: Assesing Risk Factors for nausea and vomiting. Anesth Analg 1994:78:7-16
  5. Altıntaş A, Vardar MA, Dilci E. Sisplatin içeren kanser kemoterapisinde ondansetron ve tropisetronun antiemetik etkinliklerinin karşılaştırılması. Çukurova Üniversitesi Tıp Fakültesi Dergisi 1998;2:72-5
  6. Gürşes E, Serin S, Tomatır E, Balcı E, Gönüllü M. Tramadola bağlı bulan¬ tı kusmayı önlemede metoklopramid, droperidol ve ondansetronun karşılaş¬ tırılması. Kocatepe Tıp Dergisi 2003;2:23-8
  7. Alon E, Himmelseher S. Ondansetron in the treatment of postoperative vomiting: a randomized, double-blind comparison with droperidol and metoclopramide. Anesth Analg 1992;75:561-5
  8. LeBourgeois JP, McKenna CJ, Coster B, Feyer P, Franzen L, Goedhals L, Marzecki Z, Souhami L, Stewart A, Tonnessen F, Haigh C, Mitchell T, Wilkinson JR, Graham E. Efficacy of an ondansetron orally disintegrating tablet: a novel oral formulation of this 5-HT(3) receptor antagonist in the treatment of fractionated radiotherapy-induced nausea and emesis. Emesis Study Group for the Ondansetron Orally Disintegrating Tablet in Radiotherapy Treatment. Clin Oncol 1999; 11:340-7
  9. Melnick BM. Ekstrapramidal reactions to low-dose droperidol. Anesthesiology 1988;69:424-6
  10. Fox-Geiman MP, Fisher SG, Kiley K, Fletcher-Gonzalez D, Porter N, Stiff P. Double-blind comparative trial of oral ondansetron versus oral granisetron versus IV ondansetron in the prevention of nausea and vomiting associated with highly emetogenic preparative regimens prior to stem cell transplantation. Biol Blood Marrow Transplant 2001;7:596-603
  11. Bilgin T, İşler C. Cisplatin içerikli kanser kemoterapisinde ondansetron ve tropisetronun antiemetik etkinliği. Jinekoloji ve Obstetrik Bülteni 1997;6:10-3
  12. Bodner M, White PF. Antiemetic efficacy of ondansetron after outpatient laparoscopy. Anesth Analg 1991;73:250-4
  13. Leeser J, Lip H. Prevention of postoperative nausea and vomiting using ondansetron, a new, selective, 5-HT3 recepto