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Journals / Journal of the Turkish-German Gynecological Association / 2006 / Cilt: 7 - Sayı: 3

Yardımla üreme teknikleri sikluslarında ovaryen yanıtının prediksiyonunda altıncı gün serum artış oranının önemi

Predicting the ovarian response in ART cycles using rate of increase in serum estradiol on day six of controlled ovarian hyperstimulation

Rajesh BHAKTA
Satish Kumar ADIGA
Pratap KUMAR
Pages
224–228
Publication Date
2022-10-18
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Discussion: In a COH cycle, there is significant predictive association between ROI-E2 on day six and good ovarian response and hyper-response.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Although, earlier studies have evaluated the significance of various estradiol patterns during controlled ovarian hyperstimulation (COH), their prognostic significance remains unclear.
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Key Findings & Data:The objective of this study is to investigate the rate of increase in estradiol (ROI-E2) during COH and evaluate it as a predictor of ovarian response.
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Conclusion & Impact:Discussion: In a COH cycle, there is significant predictive association between ROI-E2 on day six and good ovarian response and hyper-response.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Although, earlier studies have evaluated the significance of various estradiol patterns during controlled ovarian hyperstimulation (COH), their prognostic significance remains unclear. The objective of this study is to investigate the rate of increase in estradiol (ROI-E2) during COH and evaluate it as a predictor of ovarian response. Materials and Methods: In this retrospective study, 130 patients undergoing COH for IVF/ICSI cycles were reviewed. The E2 level during COH was evaluated on day 1, 5, 6, 7 & 8 and the ROI-E2 was determined. Age, basal FSH, number of mature follicles, number and maturity of oocytes, and incidence of ovarian hyperstimulation syndrome (OHSS) were recorded and their relationship with ROI-E2 was determined. Results: Patients with elevated basal FSH have shown poor ROI-E2 on day six and a significant negative correlation was observed. Similarly, patients with advanced age group demonstrated poor ROI-E2 on day six. The average ROI-E2 on day six was significantly higher in patients who developed OHSS than non-OHSS group. The number of follicles, oocytes and maturity of the oocytes were maximum among the patients with higher ROI-E2 on day six. Discussion: In a COH cycle, there is significant predictive association between ROI-E2 on day six and good ovarian response and hyper-response.

Özet

Amaç: Her ne kadar önceki çalışmalarda kontrollü ovaryen hiperstimülasyon esnasında değişik östrojen paternlerinin önemi araştırılşmış olsa da, prognostik önemleri halen bilinmemektedir. Bu çalışmanın amacı ovaryen yanıtın prediksiyonunda östrojen artış oranının (ROI-E2) önemini araştırmaktır. Materyal ve Metot: Bu retrospektif çalışmada, IVF/ICSI siklusu için kontrollü ovaryen hiperstimülasyon yapılan 130 hasta tekrar gözden geçirilmiştir. Kontrollü ovaryen hiperstimülasyon esnasında, serum E2 düzeyi 1., 5., 6., 7. ve 8. günlerde incelenmiş ve ROI-E2 değerleri hesaplanmıştır. Yaş, bazal FSH, matür folikül sayısı, oosit matürasyonu ve sayıs› ile ovaryen hiperstimülasyon sendromu (OHSS) insidansı rapor edilmiş ve bunların ROI-E2 ile ilişkileri araştırılmıştır. Sonuç: Artmış bazal FSH düzeyi olan hastalar, altıncı günde zayıf ROI-E2 göstermiş ve bu hastalarda anlamlı bir negatif korelasyon tespit edilmiştir. Ayrıca, ileri yaştaki hastalarda da zayıf ROI-E2 değerleri 6. günde gözlenmiştir. Altıncı gündeki ortalama ROI-E2 değerleri, OHSS olan hastalarda olmayanlara göre anlamlı olarak yüksek bulunmuştur. Folikül sayısı, oosit sayı ve matürasyonu, altıncı günde yüksek ROI-E2 olan hastalarda yine anlamlı olarak yüksektir. Tartışma: Kontrollü ovaryen hiperstimülasyonda altıncı günde elde edilen ROI-E2 değerleri ile iyi ve aşırı ovaryen yanıt arası nda anlamlı bir prediktif ilişki mevcuttur

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Cite This Article

BHAKTA, R., ADIGA, S. K., KUMAR, P. (2022). Yardımla üreme teknikleri sikluslarında ovaryen yanıtının prediksiyonunda altıncı gün serum artış oranının önemi. Journal of the Turkish-German Gynecological Association, Cilt: 7 - Sayı: 3, 224–228. https://ajindex.com/articles/567977

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