Testis spectroscopy may predict sperm retrieval rate in men with non-obstructive azoospermia undergoing micro-TESE: A pilot study

For positive sperm retrieval in micro-TESE, the cut-off value of Cho was 1.46 ppm, the cut-off value ofCr was 1.43 ppm, and the cut-off value of MI was 0.79 ppm.Conclusion: Testis spectroscopy can be used as a non-invasive screening method to predict the success or failure of micro-TESE. (J Turk GerGynecol Assoc 2020; 21: 70-8)

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: To investigate whether prior testis magnetic resonance spectroscopy predicts the success or failure of micro-dissection testicularsperm extraction (micro-TESE) in patients with non-obstructive azoospermia (NOA).Material and Methods: Nine men with NOA who were scheduled for micro-TESE for the first time, 9 NOA men with a history of previousmicro-TESE and 5 fertile men were enrolled.

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Key Findings & Data:Ahigh Cho peak was detected in 87% of the NOA men with positive sperm retrieval.

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Conclusion & Impact:For positive sperm retrieval in micro-TESE, the cut-off value of Cho was 1.46 ppm, the cut-off value ofCr was 1.43 ppm, and the cut-off value of MI was 0.79 ppm.Conclusion: Testis spectroscopy can be used as a non-invasive screening method to predict the success or failure of micro-TESE. (J Turk GerGynecol Assoc 2020; 21: 70-8)

🔬Design:Research Article

📍Scope:2020 Verileri

⚙️Variables:Domain Parameters

Abstract

Objective: To investigate whether prior testis magnetic resonance spectroscopy predicts the success or failure of micro-dissection testicularsperm extraction (micro-TESE) in patients with non-obstructive azoospermia (NOA).Material and Methods: Nine men with NOA who were scheduled for micro-TESE for the first time, 9 NOA men with a history of previousmicro-TESE and 5 fertile men were enrolled. All NOA patients and fertile controls underwent testis spectroscopy. A multi-voxel spectroscopysequence was used. Testicular signals of choline (Cho), creatine (Cr), myo-inositol (MI), lactate, and lipids were analyzed quantitatively andcompared with the results of the micro-TESEs.Results: The most prominent peaks were Cho and Cr in the fertile controls and NOA subjects with positive sperm retrieval in the micro-TESE. Ahigh Cho peak was detected in 87% of the NOA men with positive sperm retrieval. NOA men without sperm at the previous micro-TESE showeda marked decrease in Cho and Cr signals. For positive sperm retrieval in micro-TESE, the cut-off value of Cho was 1.46 ppm, the cut-off value ofCr was 1.43 ppm, and the cut-off value of MI was 0.79 ppm.Conclusion: Testis spectroscopy can be used as a non-invasive screening method to predict the success or failure of micro-TESE. (J Turk GerGynecol Assoc 2020; 21: 70-8)

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Cite This Article

KÜÇÜK, T., ÖZENER, V., ÇELİK, Ö., HATIRNAZ, Ş., Erşahin, A., BAŞBUĞ, A., YILDIRIM, G. Y., ÇELİK, S., ÇELİK, N., ÜNLÜ, C., GÜRPINAR, N. (2022). Testis spectroscopy may predict sperm retrieval rate in men with non-obstructive azoospermia undergoing micro-TESE: A pilot study. Journal of the Turkish-German Gynecological Association, Cilt: 21 - Sayı: 2, 70–78. https://ajindex.com/articles/567955

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References (13)

Silber SJ, Van Sterirteghem A, Nagy Z, Liu J, Tournaye H, Devroey P. Normal pregnancies resulting from testicular sperm extraction and ıntracytoplasmic sperm injection for azoospermia due to maturation arrest. Fertil Steril 1996; 66: 110-7.
Chan PT, Schlegel PN. Nonobstructive azoospermia. Curr Opin Urol 2000; 10: 617-24.
Wald M, Niederberger CS, Ross LS. Surgical sperm retrieval for assisted reproduction. Minerva Ginecol 2004; 56: 217-22.
Schlegel PN, Su LM. Physiological consequences of testicular sperm extraction. Hum Reprod 1997; 12: 1688-92.
Brandell RA, Mielnik A, Liotta D, Ye Z, Veeck LL, Palermo GD, et al. AZFb deletions predict the absence of spermatozoa with testicular sperm extraction: preliminary report of a prognostic genetic test. Hum Reprod 1998; 13: 2812-5.
Hopps CV, Mielnik A, Goldstein M, Palermo GD, Rosenwaks Z, Schlegel PN. Detection of sperm in men with y chromosome microdeletions of the AZFa, AZFb and AZFc regions. Hum Reprod 2003; 18: 1660-5.
Huang X, Bai Q, Yan LY, Zhang QF, Geng L, Qiao J. Combination of serum inhibin b and follicle-stimulating hormone levels can not improve the diagnostic accuracy on testicular sperm extraction outcomes in chinese non-obstructive azoospermic men. Chin Med J (Engl) 2012; 125: 2885-9.
AbdelRaheem A, Garaffa G, Rushwan N, De Luca F, Zacharakis E, AbdelRaheem T, et al. Testicular histopathology as a predictor of a positive sperm retrieval in men with non-obstructive azoospermia. BJU Int 2013; 111: 492-9.
Khelaia A, Saker Z, Tsintsadze O, Managadze L. Nonobstructıve azoospermıa, follıcle-stımulatıng hormone as a marker of successful sperm retrıeval. Georgian Med News 2015; 249: 34-7.
Martin-du-Pan RC, Bischof P. Increased follicle stimulating hormone in infertile men. is increased plasma fsh always due to damaged germinal epithelium? Hum Reprod 1995; 10: 1940-5.
Takahira H, Sakatoku J, Fujii M, Nasu T, Cosentino MJ, Cockett AT. Significance of testicular size measurement in andrology. i. a new orchiometer and its clinical application. Fertil Steril 1983; 39: 836- 40. Patel PJ, Pareek SS. Scrotal ultrasound in male infertility. Eur Urol 1989; 16: 423-5.
Tsili AC, Ntorkou A, Goussia A, Astrakas L, Panopoulou E, Sofikitis N, et al. Diffusion tensor imaging parameters in testes with nonobstructive azoospermia. J Magn Reson Imaging 2018; 48: 1318-25.
Ramasamy R, Sterling J, Fisher ES, Li PS, Jain M, Robinson BD, et al. Identification of spermatogenesis with multiphoton microscopy: an evaluation in a rodent