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Journals / Journal of the Turkish-German Gynecological Association / 2007 / Cilt: 8 - Sayı: 4

Hipogonadotrofik hipogonadizmi olan bir kadında IVF siklusunda rekombinant FSH ile indüksiyon sonrası Düşük doz hCG ile elde edilen başarılı gebelik

Successful pregnancy in a woman with hypogonadotrophic hypogonadism using low dose hCG after priming with recombinant FSH in an IVF cycle

Elvan OK
Fulya AYDINER
Karagöz Fulya AKIN
Erbil DOĞAN
Bülent GÜLEKLİ
Pages
428–430
Publication Date
2022-10-18
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Randomized controlled studies are needed to support this conclusion.

📌 3 Key Takeaways

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Objective & Hypothesis:In this case report, we present a 34-year old woman with hypogonadotrophic hypogonadism in which we used low dose human chorionic gonadotrophin (150 IU/day) as luteinizing hormone supplement after priming with recombinant follicle stimulating hormone in an assisted reproduction cycle.
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Key Findings & Data:Twenty-five oocytes were retrieved, 14 oocytes underwent intracytoplasmic sperm injection and 13 were fertilized and all of them cleaved.
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Conclusion & Impact:Randomized controlled studies are needed to support this conclusion.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

In this case report, we present a 34-year old woman with hypogonadotrophic hypogonadism in which we used low dose human chorionic gonadotrophin (150 IU/day) as luteinizing hormone supplement after priming with recombinant follicle stimulating hormone in an assisted reproduction cycle. Twenty-five oocytes were retrieved, 14 oocytes underwent intracytoplasmic sperm injection and 13 were fertilized and all of them cleaved. Four embryos were transferred on day 2. The result was a twin pregnancy. The patient had an uneventful pregnancy and at 38th weeks of gestation delivered two healthy female and male infants weighing 3015 g and 2876 g, respectively. As a conclusion, low dose human chorionic gonadotrophin administration in the late follicular phase of the ovulation induction cycle may be an effective way to provide luteinizing hormone like activity in hypogonadotrophic patients. Randomized controlled studies are needed to support this conclusion.

Özet

Otuz dört yaşında ve hipogonadotrofik hipogonadizme bağlı primer infertilitesi olan bir hastaya yardımcı üreme tekniği sırasında ovülasyon indüksiyonu için rekombinant folikül stimüle edici hormon (recFSH) ile indüksiyon sonrası luteinizan hormon (LH) desteği amacıyla düşük doz insan koryonik gonadotropini (150 IU/gün) uygulaması yapılmıştır. Yazımızda bu olguyu sunuyoruz. Hastadan 25 oosit elde edildi, 14’üne sitoplazma içine sperm enjeksiyonu uygulandı, 13’ü döllendi ve bunların hepsinde klivaj elde edildi. İkinci günde transfer edilen 4 embriyo ikiz gebelikle sonuçlandı. Hastanın gebeliği sorunsuz geçti ve 38. gebelik haftasında 3015 g kuz ve 2876 g erkek sağlıklı bebek doğurtuldu. Sonuç olarak, yumurtlama sürecinin geç folikül süresinde uygulanan düşük doz insan koryonik gonadotropini, hipogonadotropik hastalarda luteinizan hormon aktivitesini elde etmede etkili bir yöntem olabilir. Bu sonucu desteklemek için rasgele yöntemli, kontrollü çalışmalara gerek vardur.

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Cite This Article

OK, E., AYDINER, F., AKIN, K. F., DOĞAN, E., GÜLEKLİ, B. (2022). Hipogonadotrofik hipogonadizmi olan bir kadında IVF siklusunda rekombinant FSH ile indüksiyon sonrası Düşük doz hCG ile elde edilen başarılı gebelik. Journal of the Turkish-German Gynecological Association, Cilt: 8 - Sayı: 4, 428–430. https://ajindex.com/articles/567943

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References (10)

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