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Journals / Journal of the Turkish-German Gynecological Association / 2007 / Cilt: 8 - Sayı: 4

Yumurtlama başlatılması için klomifen sitrata ek olarak rekombinant folikül uyarıcı hormon ile yeni bir düşük doz stimülasyon protokolünün sadece rekombinant folikül uyarıcı hormon kullanımı ile karşılaştırılması: Prospektif bir çalışma

Comparison of a novel minimal stimulation protocol with clomiphene citrate plus recombinant follicle-stimulating hormone to recombinant follicle-stimulating hormone alone for ovulation induction: A prospective study

Gülay BEYDİLİ
Berfu DEMİR
Ali HABERAL
Müberra KOÇAK
Orhan GELİŞEN
Metin ALTAY
Pages
397–401
Publication Date
2022-10-18
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The cost was significantly different between the groups (p

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The aim of this study has been to compare a combined minimal stimulation protocol with clomiphene citrate (CC) plus recombinant FSH (recFSH) to the standard protocol using recFSH only.
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Key Findings & Data:Materials and Methods: In the study group (n=34), CC 100 mg/day, was used between the cycle days of three to seven, and recFSH was used on cycle days 5, 7, and 9 at a fixed dosage of 75 units.
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Conclusion & Impact:The cost was significantly different between the groups (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: The aim of this study has been to compare a combined minimal stimulation protocol with clomiphene citrate (CC) plus recombinant FSH (recFSH) to the standard protocol using recFSH only. Materials and Methods: In the study group (n=34), CC 100 mg/day, was used between the cycle days of three to seven, and recFSH was used on cycle days 5, 7, and 9 at a fixed dosage of 75 units. In the control group (n=31), 75 units of recFSH was started on cycle day 3, and dosage was adjusted to the ovarian response. Results: Total dose per treatment cycle was 225 units of recFSH in the study group, and 805.64±515.00 units of recFSH in the control group. The cost was significantly different between the groups (p

Özet

Amaç: Bu çalışmanın amacı, klomifen sitrat (CC) ve rekombinant FSHnin (recFSH) birlikte kullanıldığı düşük dozlu stimülasyon protokolünün tek başına recFSHnin kullanıldığı standart protokol ile karşılaştırmaktır. Materyal ve Metot: Çalışma grubunda (n=34), siklusun üçüncü ila yedinci günleri arasında 100 mg/gün CC kullanıldı. Buna ek olarak siklusun 5, 7 ve 9. günlerinde 75 ünite sabit dozda recFSH eklendi. Kontrol grubunda (n=31) siklusun 3. gününde 75 ünite recFSH başlanarak doz yumurtalık yanıtına göre ayarlandı. Sonuçlar: Çalışma grubunda recFSH dozu tedavi siklusu başına 225 ünite iken, kontrol grubunda bu doz 805.64±515.00 ünite idi. Tedavi maliyeti, gruplar arasında anlamlı şekilde farklıydı (p

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Cite This Article

BEYDİLİ, G., DEMİR, B., HABERAL, A., KOÇAK, M., GELİŞEN, O., ALTAY, M. (2022). Yumurtlama başlatılması için klomifen sitrata ek olarak rekombinant folikül uyarıcı hormon ile yeni bir düşük doz stimülasyon protokolünün sadece rekombinant folikül uyarıcı hormon kullanımı ile karşılaştırılması: Prospektif bir çalışma. Journal of the Turkish-German Gynecological Association, Cilt: 8 - Sayı: 4, 397–401. https://ajindex.com/articles/567930

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References (11)

  1. Diamond MP, Hill GA, Webster BW et al. Comparison of human menopausal gonadotropin, clomiphene citrate, and combined human menopausal gonadotropin-clomiphene citrate stimulation protocols for in vitro fertilization. Fertil Steril 1986;46:1108-12
  2. Corfman RS, Milad MP, Bellavance TL et al. A novel ovarian stimulation protocol for use with the assisted reproductive technologies. Fertil Steril 1993;60:864-70
  3. Dhaliwal LK, Sialy RK, Gopalan S, Majumdar S. Minimal stimulation protocol for use with intrauterine insemination in the treatment of infertility. J Obstet Gynecol Res 2002 Dec;28(6):295-9
  4. Weigert M, Krischker U, Pohl M et al. Comparison of stimulation with clomiphene citrate in combination with recombinant follicle stimulating hormone and recombinant luteinizing hormone to stimulation with a gonadotropin releasing hormone agonist protocol: a prospective, randomized study. Fertil Steril 2002 Jul;78(1):34-9
  5. Houmard BS, Juang MP, Soules MR, Fujimoto VY. Factors influencing pregnancy rates with a combined clomiphene citrate/gonadotropin protocol for non-assisted reproductive technology fertility treatment. Fertil Steril 2002 Feb;77(2):384-6
  6. Frydman R, Rainhorn J, Forman R et al. Pregnancies following fixed schedule ovulation induction and embryo cryopreservation during diagnostic infertility laparoscopy. In: Future aspects in human in vitro fertilization. Frichlinger W, Keureter D, eds. Berlin, Germany: Springer Verlag 1987:82-90
  7. Williams SC, Gibbons WE, Muasher SJ, Oehninger S. Minimal ovarian hyperstimulation for in vitro fertilization using sequential clomiphene citrate and gonadotropin with or without the addition of a gonadotropinreleasing hormone antagonist. Fertil Steril 2002;78(5):1068-72
  8. Glazener CM, Coulson C, Lambert PA et al. Clomiphene treatment for women with unexplained infertility: placebo-controlled study of hormonal responses and conception rates. Gynecol Endocrinol 1990;4:75-83
  9. Biljan MM, Mahutte NG, Tulandi T, Tan SL. Prospective randomized double-blind trial of the correlation between time of administration and antiestrogenic effects of clomiphene citrate on reproductive end organs. Fertil Steril 1999;71:633-8
  10. Ovulation Induction. In: Gordon JD, Speroff L, editors. Handbook for Clinical Gynecologic Endocrinology and Infertility. Philadelphia, USA: Lippincott Williams&Wilkins; 2002. p. 461-2
  11. Hughes E, Collins J, Vandekerckhove P. Ovulation induction with urinary follicle stimulating hormone vs h