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Journals / Journal of the Turkish-German Gynecological Association / 2007 / Cilt: 8 - Sayı: 1

Hipoksik-iskemik ensefalopatili term bebeklerde, serebral hemodinamiğin düzenlenmesinde IL-6, IL-8 ve TNF-α’nin rolü ve mekanizması

The role and mechanisms of IL-6, IL-8 and TNF-α for regulating cerebral hemodynamics in term infants with hypoxic-ischemic encephalopathy

Ying Hai CAO
Hang Fan MENG
Ping Xiao RONG
Jing LIU
Pages
63–66
Publication Date
2022-10-18
DOI
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⚡ TL;DR(Too Long; Didn't Read)

RESULTS: The results showed in infants with hypoxic-ischemic encephalopathy, the plasma levels of IL-8 and TNF-α were increased while the serum levels of IL-6 were decreased, which were correlated with disturbed cerebral hemodynamics and the changes of plasma levels ET-1 and cGRP.

📌 3 Key Takeaways

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Objective & Hypothesis:OBJECTIVE: It is well known that cytokines play important role in the pathophysiologic mechanisms of neonatal hypoxic-ischemic encephalopathy (HIE).
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Key Findings & Data:STUDY DESIGN: The levels of peripheral blood interleukin-6 (IL-6), interleukin-8(IL-8), tumor necrosis factor-alpha (TNF-α), and endothelin-1(ET-1), calcitonin gene-related peptide (cGRP) in 30 hypoxic-ischemic encephalopathic and 30 healthy neonates were detected on the1st day of life using radioimmunoassay.
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Conclusion & Impact:RESULTS: The results showed in infants with hypoxic-ischemic encephalopathy, the plasma levels of IL-8 and TNF-α were increased while the serum levels of IL-6 were decreased, which were correlated with disturbed cerebral hemodynamics and the changes of plasma levels ET-1 and cGRP.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

OBJECTIVE: It is well known that cytokines play important role in the pathophysiologic mechanisms of neonatal hypoxic-ischemic encephalopathy (HIE). Cytokines can regulate the cerebral hemodynamics, however their mechanisms have been reported rarely. This study was to explore the role and the mechanisms of cytokines on regulating cerebral hemodynamics in neonates with HIE. STUDY DESIGN: The levels of peripheral blood interleukin-6 (IL-6), interleukin-8(IL-8), tumor necrosis factor-alpha (TNF-α), and endothelin-1(ET-1), calcitonin gene-related peptide (cGRP) in 30 hypoxic-ischemic encephalopathic and 30 healthy neonates were detected on the1st day of life using radioimmunoassay. And hemodynamic parameters of middle cerebral artery including peak systolic flow velocity (PSFV, cm/s), end-diastolic flow velocity (EDFV, cm/s),time-averaged mean velocity(TMFV, cm/s), pulsatility index (PI) and resistance index (RI) in both groups were measured by pulsed Doppler ultrasound after the blood samples had been collected immediately. RESULTS: The results showed in infants with hypoxic-ischemic encephalopathy, the plasma levels of IL-8 and TNF-α were increased while the serum levels of IL-6 were decreased, which were correlated with disturbed cerebral hemodynamics and the changes of plasma levels ET-1 and cGRP. Linear correlation analysis showed RI was positively correlated with IL-8 (r=0.80; p

Özet

AMAÇ: Sitokinlerin, neonatal hipoksik-iskemik ensefalopatisinin (HIE) patofizyolojik mekanizmalarında önemli bir rolü olduğu bilinmektedir. Ancak sitokinlerin serebral hemodinamiği düzenleyip düzenlemedikleri ve mekanizmalarına dair bilgiler çok azdır. Bu çalışmanın amacı sitokinlerin HIE’li yenidoğanlarda serebral hemodinamiği düzenlemedeki rolünü ve mekanizmalarını araştırmaktır. METOD: 30 hipoksik-iskemik ensefalopatili ve 30 sağlıklı yenidoğanda doğdukları gün radioimunoassay kullanılarak periferal kan interlökin-6 (IL-6), interlökin-8 (IL-8), tümör nekrozis faktör- alfa (TNF-α), endotelin-1 (ET-1) ve kalsitonin gen ilişkili peptit (CGRP) seviyeleri belirlenmiştir. Ayrıca kan örneklerinin hemen alınmasından sonra pulsed Doppler ulrason ile iki gruptaki pik sistolik akım hızı (PSFV, cm/s), son-diyastolik akım hızı (EDFV, cm/s), zaman-ortalamalı ortalama akım hızı (TMFV, cm/s), pulsatilite endeksi (PI) ve rezistans endeksi (RI) dahil olmak üzere orta serebral arterin hemodinamik parametreleri ölçülmüştür. SONUÇ: Bulgular hipoksik-iskemik ensefalopatisi olan çocuklarda IL-8, TNF-α plazma seviyeleri artarken, IL-6 serum seviyelerinin azaldığını göstermiştir. Bu sonuçlar bozulmuş serebral hemodinami ve ET-1 ve cGRP plazma seviyelerindeki değişikliklerle korele idi. Lineer korelasyon analizi RI’nın IL-8 (r=0.80, p

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Cite This Article

CAO, Y. H., MENG, H. F., RONG, P. X., LIU, J. (2022). Hipoksik-iskemik ensefalopatili term bebeklerde, serebral hemodinamiğin düzenlenmesinde IL-6, IL-8 ve TNF-α’nin rolü ve mekanizması. Journal of the Turkish-German Gynecological Association, Cilt: 8 - Sayı: 1, 63–66. https://ajindex.com/articles/567917

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