AI Summary & Key Takeaways
AI InsightConclusion: When single and two courses of antenatal steroid therapy were compared, there was no statistically significant difference between groups regarding the incidence of RDS and mechanical ventilator treatment.
📌 3 Key Takeaways
Abstract
Objective: We aimed to evaluate the effects of single and double courses of antenatal corticosteroid administration on neonatal mortality and morbidity. Material and Methods: 232 preterm babies delivered between 01.April 2007 and 31. March 2008 with gestational ages of 26- 34 weeks were evaluated prospectively. Infants were divided into three groups. The first group did not receive any antenatal betamethasone therapy. The second group received single (two doses of 12 mg betamethasone administered at 24 hour intervals) and the third group received double (repeated course after one week) courses of betamethasone therapy. Results: 156 (67.2%) infants received at least one dose of corticosteroid treatment where 76 (37.8%) did not. Of 156 infants who had received antenatal betamethasone, 36 (23.1%) developed respiratory distress syndrome (RDS), while the incidence of RDS was 35.5% in 76 preterms who didn’t receive antenatal betamethasone (27/76) (p0.05). Conclusion: When single and two courses of antenatal steroid therapy were compared, there was no statistically significant difference between groups regarding the incidence of RDS and mechanical ventilator treatment.
Özet
Amaç: Tek ve çift doz antenatal kortikosteroid uygulamasının neonatal mortalite ve morbiditesi üzerine olan etkisini incelemeyi amaçladık. Materyal ve Metod: 1 Nisan 2007 ve 31 Mart 2008 tarihleri arasında gestasyonel yaşları 26 – 34 hafta arasında olup doğurtulan 232 preterm bebek prospektif olarak değerlendirildi. İnfantlar üç gruba ayrıldı. Birinci grup antenatal betametazon tedavisi almadı. İkinci grup yirmidört saat arayla iki doz 12 mg betametazon alırken üçüncü grup bir hafta arayla ikinci betametazon tedavisi aldı. Bulgular: 156 (%67.2) infant en az tek doz kortikosteroid tedavisi alırken 76’sı (%37.8) kortikosteroid almadı. Antenatal betametazon alan 156 infanttan 36’sında (%23.1) respiaratuar distres sendromu (RDS) gelişirken antenatal betametazon almayan 76 pretermden 27’sinde (%35.5) RDS gelişti (p0.05) Sonuç: Tek kür ve iki kür betametazon uygulaması karşılaştırıldığında, RDS insidansı ve mekanik ventilasyon ihtiyacı yönünden iki grup arasında istatistiksel olarak anlamlı bir fark saptanmadı (p>0.05).