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Journals / Journal of the Turkish-German Gynecological Association / 2013 / Cilt: 14 - Sayı: 2

Melatonin tedavisi ooferektomize sıçanlar endometriozis modelinde endometriotik odaklarda gerilemeye yol açar

Melatonin treatment results in regression of endometriotic lesions in an ooferectomized rat endometriosis model

Rukset ATTAR
Gazi YILDIRIM
Cem FIÇICIOĞLU
Ferda ÖZKAN
Narter YEŞİLDAĞLAR
Nilüfer KOCADAL ÇE"TİNKAYA
Bayram YILMAZ
Pages
81–86
Publication Date
2022-10-18
DOI
—
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⚡ TL;DR(Too Long; Didn't Read)

Also, when the melatonin group wasanalysed within itself, endometriotic lesion volumes decreased andhistopathological scores increased significantly.Conclusion: Melatonin causes regression of the endometriotic lesions in rats and improvement in their histopathological scores.(J Turkish-German Gynecol Assoc 2013; 14: 81-6)

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: We aimed to determine the effects of melatonin treatment on endometrial implants in an oopherectomized rat endomeriosis model.Material and Methods: This study is a prospective, randomised,controlled experimental study.
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Key Findings & Data:In the melatonin group, rats were treatedwith melatonin (20 mg/kg/day) for two weeks.
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Conclusion & Impact:Also, when the melatonin group wasanalysed within itself, endometriotic lesion volumes decreased andhistopathological scores increased significantly.Conclusion: Melatonin causes regression of the endometriotic lesions in rats and improvement in their histopathological scores.(J Turkish-German Gynecol Assoc 2013; 14: 81-6)
🔬Design:Modeling & Simulation
📍Scope:2013 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: We aimed to determine the effects of melatonin treatment on endometrial implants in an oopherectomized rat endomeriosis model.Material and Methods: This study is a prospective, randomised,controlled experimental study. It was carried out at the Experimenal Research Center of Yeditepe University (YUDETAM). Twenty-two,emale, non-pregnant, nulligravid Spraque-Dawley albino rats werencluded in our study. Endometriosis was surgically induced in oopherectomized rats. Rats were randomised into two groups: controlgroup and melatonin group. In the melatonin group, rats were treatedwith melatonin (20 mg/kg/day) for two weeks. After the operationswere performed to assess the regression of the endometriotic lesions,melatonin treatment was stopped. At the end of the sixth week nec-ropsies were performed to assess the rate of recurrence. The volumeand histopathological scores of endometriotic foci were examined.Results: Volumes of the endometriotic lesions significantly decreased in the melatonin group. Also, when the melatonin group wasanalysed within itself, endometriotic lesion volumes decreased andhistopathological scores increased significantly.Conclusion: Melatonin causes regression of the endometriotic lesions in rats and improvement in their histopathological scores.(J Turkish-German Gynecol Assoc 2013; 14: 81-6)

Özet

Amaç: Ooferektomize sıçan endometriozis modelinde melatoninin endometriotik odaklar üzerine etkisini incelemeyi amaçladık Gereç ve Yöntemler: Bu çalışma prospektif, randomize, kontrollü, deneysel bir çalışmadır. Çalışma Yeditepe Üniversitesi Deneysel Araştırma Merkezinde (YÜDETAM) yapıldı. Deneysel çalışmamıza 22 adet dişi, gebe olmayan, nulligravid Spraque-Dawley albino sıçan dahil edildi. Ooferektomize edilen sıçanlarda cerrahi olarak endometriozis oluşturuldu. Sıçanlar iki gruba ayrıldı: kontrol grubu ve melatonin grubu. Melatonin grubunda 2 hafta boyunca sıçanlara melatonin (20 mg/ kg/gün) tedavisi verildi. Endometriotik regresyonu değerlendirmek için operasyonlar yapıldıktan sonra melatonin tedavisi sonlandırıldı. Rekürrens oranlarını değerlendirmek için altıncı haftanın sonunda nekropsiler yapıldı. Endometriotik odakların hacim ve histopatolojik skorları değerlendirildi. Bulgular: Endometriotik lezyonların hacimleri melatonin grubunda anlamlı derecede azaldı. Ayrıca, melatonin grubu kendi içerisinde incelendiğinde endometriotik lezyonların hacimlerinin anlamlı derecede azaldı ve histopatolojik skorları anlamlı derecede arttı. Sonuç: Melatonin sıçanlarda endometriotik odakların gerilemesine ve histopatolojik skorların iyileşmesine neden olur. (J Turkish-German Gynecol Assoc 2013; 14: 81-6)

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Cite This Article

ATTAR, R., YILDIRIM, G., FIÇICIOĞLU, C., ÖZKAN, F., YEŞİLDAĞLAR, N., ÇE"TİNKAYA, N. K., YILMAZ, B. (2022). Melatonin tedavisi ooferektomize sıçanlar endometriozis modelinde endometriotik odaklarda gerilemeye yol açar. Journal of the Turkish-German Gynecological Association, Cilt: 14 - Sayı: 2, 81–86. https://ajindex.com/articles/567635

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