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Journals / Journal of the Turkish-German Gynecological Association / 2013 / Cilt: 14 - Sayı: 2

Lipoik asitin deneysel sıçan modelinde peritoneal adezyon oluşumunu azaltıcı etkisi

Lipoic acid decreases peritoneal adhesion formation in a rat uterine scar model

Aslı GÖKER
Serap MICILI ÇİLAKER
Bekir Uğur ERGÜR
Pınar AKOKAY
Oya SAYIN
Pages
76–80
Publication Date
2022-10-18
DOI
—
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Conclusion: Lipoic acid was found to be effective in reducing postoperative adhesion formation in a rat model. (J Turkish-German Gynecol Assoc 2013; 14: 76-80)

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Objective & Hypothesis:Objective: To investigate the effects of lipoic acid in the preventionof postoperative pelvic adhesions by a visual scoring system and im munohistochemistry in a rat uterine horn model with full thicknessnjury.Material and Methods: Twenty-eight female Wistar albino rats wererandomised into four groups: uterine trauma control, 15 days and 30days, and uterine trauma + lipoic acid, 15 days and 30 days.
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Key Findings & Data:A fullhickness defect was established by incising a segment of approxi mately 1.0 cm in length from each uterine horn, leaving the mesome rium intact.
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Conclusion & Impact:Conclusion: Lipoic acid was found to be effective in reducing postoperative adhesion formation in a rat model. (J Turkish-German Gynecol Assoc 2013; 14: 76-80)
🔬Design:Modeling & Simulation
📍Scope:2013 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: To investigate the effects of lipoic acid in the preventionof postoperative pelvic adhesions by a visual scoring system and im munohistochemistry in a rat uterine horn model with full thicknessnjury.Material and Methods: Twenty-eight female Wistar albino rats wererandomised into four groups: uterine trauma control, 15 days and 30days, and uterine trauma + lipoic acid, 15 days and 30 days. A fullhickness defect was established by incising a segment of approxi mately 1.0 cm in length from each uterine horn, leaving the mesome rium intact. Extension and severity of the adhesions in each groupwere scored by a visual scoring system and evaluated immunohisto chemically. Results: Adhesion scores were 2.00±0.81, 2.14±0.69 0.71±0.75,and 0.85±0.69 for extent and 2.28±0.48, 2.14±0.69, 0.85±0.69, and1.14±0.69 for severity in Groups 1, 2, 3 and 4, respectively. Adhesionextent and severity were significantly less for groups treated by li poic acid but no difference was observed between long and shortadministration. Both Vitronectin and u-PAR staining were significantly ncreased in treatment groups when compared to the control group. Conclusion: Lipoic acid was found to be effective in reducing postoperative adhesion formation in a rat model. (J Turkish-German Gynecol Assoc 2013; 14: 76-80)

Özet

Amaç: Tam kat uterus hasarı yapılmış deneysel sıçan modelinde lipoik asitin postoperatif pelvik adezyonlar üzerindeki etkisinin incelenmesi amaçlanmıştır.Gereç ve Yöntemler: Yirmi sekiz dişi Wistar albino sıçan dört grubarandomize edildi. Uterin hasar grubu kontrol, 15 gün ve 30 gün, uterinhasar + lipoik asit grubu 15 ve 30 gün. Tam kat uterin hasar her biruterin boynuzdan 1.0 cm uzunlukta, mezometriyumu salim bırakarakinsizyon yapılarak ve sütüre edilerek oluşturuldu. Adezyonların yaygınlığı ve şiddeti görsel skorlama sistemi ile ve immunohistokimyasalolarak yapıldı.Bulgular: Adezyon skorları grup 1, 2, 3 ve 4 için sırasıyla yaygınlık: 2.00±0.81, 2.14±0,69 0.71±0.75, 0.85±0.69 ve şiddet: 2.28±0.48,2.14±0.69, 0.85±0.69,1.14±0.69 olarak belirlendi. Adezyon yaygınlıkve şiddeti lipoik asit ile tedavi edilen grupta anlamlı olarak daha azdıancak kısa veya uzun süreli kullanım arasında fark yoktu. Hem Vitro nectin hem u-Par boyanması tedavi grubunda kontrole göre anlamlıolarak artmıştı. Sonuç: Lipoik asit deneysel sıçan modelinde postoperatif adezyon oluşumunu önlemede etkili bulundu. (J Turkish-German Gynecol Assoc 2013; 14: 76-80)

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Cite This Article

GÖKER, A., ÇİLAKER, S. M., ERGÜR, B. U., AKOKAY, P., SAYIN, O. (2022). Lipoik asitin deneysel sıçan modelinde peritoneal adezyon oluşumunu azaltıcı etkisi. Journal of the Turkish-German Gynecological Association, Cilt: 14 - Sayı: 2, 76–80. https://ajindex.com/articles/567610

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