Journals / Journal of the Turkish-German Gynecological Association / 2013 / Cilt: 14 - Sayı: 4

Endometrioma bulunan ileri evre endometrioziste ortalama trombosit hacmi, nötrofil/lenfosit oranı ve trombosit/lenfosit oranının değerlendirilmesi

Evaluation of mean platelet volume, neutrophil/ lymphocyte ratio and platelet/lymphocyte ratio in advanced stage endometriosis with endometrioma

Pages
210–215
Publication Date
2022-10-18
DOI
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We demonstrate that MPV, NLR and PLR values are not useful for this purpose in pa- tients with advanced stage endometriosis that are proven to develop severe inflammation at either the cellular or molecular level. (J Turkish-German Gynecol Assoc 2013; 14: 210-5)

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: We compared the preoperative values of mean platelet volume (MPV) and peripheral systemic inflammatory response (SIR) markers (neutrophil/lymphocyte ratio and platelet/lymphocyte ratio) between patients with advanced-stage (stage 3/4) endometriosis hav- ing endometrioma (OMA) and patients with a non-neoplastic adnexal mass other than endometrioma (non-OMA).
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Key Findings & Data:Results: Haemoglobin levels, leucocyte count, platelet count, neu- trophil count and lymphocyte count were not significantly different between patients with advanced stage endometriosis having OMA, patients with non-OMA and patients in the control group (p=0.970, p=0.902, p=0.373, p=0.501 and p=0.463, respectively).
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Conclusion & Impact:We demonstrate that MPV, NLR and PLR values are not useful for this purpose in pa- tients with advanced stage endometriosis that are proven to develop severe inflammation at either the cellular or molecular level. (J Turkish-German Gynecol Assoc 2013; 14: 210-5)
🔬Design:Research Article
📍Scope:2013 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: We compared the preoperative values of mean platelet volume (MPV) and peripheral systemic inflammatory response (SIR) markers (neutrophil/lymphocyte ratio and platelet/lymphocyte ratio) between patients with advanced-stage (stage 3/4) endometriosis hav- ing endometrioma (OMA) and patients with a non-neoplastic adnexal mass other than endometrioma (non-OMA). Material and Methods: Patients who underwent operations with the pre-diagnosis of infertility or adnexal mass and who underwent laparoscopic tubal ligation were included. Results: Haemoglobin levels, leucocyte count, platelet count, neu- trophil count and lymphocyte count were not significantly different between patients with advanced stage endometriosis having OMA, patients with non-OMA and patients in the control group (p=0.970, p=0.902, p=0.373, p=0.501 and p=0.463, respectively). Patients with stage 3/4 endometriosis having OMA, patients with non-OMA and control patients were also not significantly different in terms of MPV (p=0.836), neutrophil/lymphocyte ratio (NLR) (p=0.555) and plate- let/lymphocyte ratio (PLR) (p=0.358). Preoperative cancer antigen 125 (Ca-125) levels were significantly higher in patients with OMA (p=0.006). Mean size of the OMAs was significantly lower than non- OMAs (p=0.000). Conclusion: It is very important to determine advanced stage endo- metriosis and OMAs during preoperative evaluation in order to inform patients and plan an appropriate surgical approach. We demonstrate that MPV, NLR and PLR values are not useful for this purpose in pa- tients with advanced stage endometriosis that are proven to develop severe inflammation at either the cellular or molecular level. (J Turkish-German Gynecol Assoc 2013; 14: 210-5)

Özet

Amaç: Biz endometrioma bulunan ileri evre endometriozise sahip hastalar (evre 3/4) ve endometrioma dışı non-neoplastik adneksiyel kitle bulunan hastalar arasında preoperatif ortalama trombosit hac- mi (MPV) ve periferik sistemik inflamatuvar yanıt (SIR) belirteçlerinin (nötrofil / lenfosit oranı ve lenfosit/trombosit oranı) değerlerini karşı- laştırdık. Gereç ve Yöntemler: İnfertilite veya adneksiyel kitle ön tanısı ile opere edilen hastalar ile laparaskopik bilateral tubal ligasyon yapılan hastalar çalışmaya dahil edilmiştir. Bulgular: Hemoglobin düzeyi, lökosit sayısı, trombosit sayısı, nötrofil sayısı ve lenfosit sayısı açısından endometrioma saptanan ileri evre endometriosis hastaları (evre 3/4), endometrioma dışı adneksiyel kitle saptanan ve kontrol grubu hastaları arasında anlamlı farklılık saptan- mamıştır (p=0.970, p=0.902, p=0.373, p=0.501 ve p=0.463; sırasıyla). Endometrioma saptanan ileri evre endometriosis hastaları (evre 3/4), endometrioma dışı adneksiyel kitle saptanan ve kontrol grubu has- taları arasında aynı zamanda MPV (p=0.836), nötrofil / lenfosit oranı (NLR) (p=0.555) ve lenfosit/trombosit oranı (PLR) (p=0.358) açısın- dan istatistiksel olarak anlamlı farklılık tespit edilmemiştir. Ameliyat öncesi kanser antijen 125 (Ca 125) seviyeleri operasyonda endometri- oma saptanan (p=0.006) hastalarda anlamlı olarak yüksek bulunmuş- tur. Endometriomaların ortalama boyutu endometrioma dışı kitlelere göre daha düşük tespit edilmiştir (p=0.000). Sonuç: İleri evre endometriozis ve endometrioma bulunan hastaları preoperatif değerlendirme sırasında belirlemek; hastayı bilgilendir- mek ve uygun cerrahi yaklaşımı planlamak için çok önemlidir. Bu çalışmada MPV, NLR ve PLR değerlerininin hücresel veya moleküler düzeyde şiddetli inflamasyon varlığı kanıtlanmış olan ileri evre endo- metriozis hastalarında bu amaç için yararlı olmadığını gösterilmiştir. (J Turkish-German Gynecol Assoc 2013; 14: 210-5)

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Cite This Article

YAVUZCAN, A., ÜSTÜN, Y., ÖZDEMİR, İ., DİLBAZ, S., KUMRU, S., YILDIZ, E., ÇAĞLAR, M., ÖZKARA, A. (2022). Endometrioma bulunan ileri evre endometrioziste ortalama trombosit hacmi, nötrofil/lenfosit oranı ve trombosit/lenfosit oranının değerlendirilmesi. Journal of the Turkish-German Gynecological Association, Cilt: 14 - Sayı: 4, 210–215. https://ajindex.com/articles/567607

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