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Journals / Journal of the Turkish-German Gynecological Association / 2014 / Cilt: 15 - Sayı: 2

Natural history of prenatal isolated muscular ventricular septal defects

Osman ŞEVKET
Seda KESKİN
Onur EROL
Hasan Fhmi YAZICIOĞLU
Ahmet GÜL
Pages
96–99
Publication Date
2022-10-18
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Overall, spontaneous closure occurred more frequently in the apical defects, but no sig- nificant difference was found for spontaneous closure between the mid-muscular and apical defects (p>0.05).

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: To evaluate the natural history of isolated muscular ventricular septal (m-VSD) defects during gestation and up to 1 year postnatally, as well as the association with chromosomal anomalies.
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Key Findings & Data:Material and Methods: Between August 2007 and July 2012, 76 fetuses with isolated m-VSDs represented the study population.
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Conclusion & Impact:Overall, spontaneous closure occurred more frequently in the apical defects, but no sig- nificant difference was found for spontaneous closure between the mid-muscular and apical defects (p>0.05).
🔬Design:Research Article
📍Scope:2007 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: To evaluate the natural history of isolated muscular ventricular septal (m-VSD) defects during gestation and up to 1 year postnatally, as well as the association with chromosomal anomalies. Material and Methods: Between August 2007 and July 2012, 76 fetuses with isolated m-VSDs represented the study population. The following variables were evaluated: site and size of the m-VSDs, presence of chromosomal anomalies, pregnancy outcome, and spontaneous closure rate from diagnosis up to 1 year postnatally. Results: Of the 76 cases with m-VSD, 1 fetus died after birth and 31 cases were lost to follow-up after birth. Thus, a total of 44 fetuses reached heir first year of postnatal life, and these cases were available for analysis. Three (6.8%) of 44 defects closed spontaneously in utero, 33 (75%) closed within 1 year, and 8 (18.2%) remained patent. Overall, spontaneous closure occurred more frequently in the apical defects, but no sig- nificant difference was found for spontaneous closure between the mid-muscular and apical defects (p>0.05). Also, 83.8% (36 of 44) of defects ≤3 mm closed during gestation or the first year of life. Conclusion: We infer that m-VSDs have a high spontaneous closure rate during the first year of life. Also, small m-VSDs frequently close spon- aneously. (J Turk Ger Gynecol Assoc 2014; 15: 96-9)

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Cite This Article

ŞEVKET, O., KESKİN, S., EROL, O., YAZICIOĞLU, H. F., GÜL, A. (2022). Natural history of prenatal isolated muscular ventricular septal defects. Journal of the Turkish-German Gynecological Association, Cilt: 15 - Sayı: 2, 96–99. https://ajindex.com/articles/567583

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