Detection of major anomalies during the first and early second trimester: Single-center results of six years

The study provides valuable information forfuture studies in Turkey and shows the need for an anatomic scan protocol while performing aneuploidy screening during early gestation. (JTurk Ger Gynecol Assoc 2018; 19: 142-5)

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Fetal structural malformations affect approximately 2-3% of all pregnancies.

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Key Findings & Data:Only focusing on trisomy screening in first trimesterand deferring the anatomic screening to second trimester may result with late detection of major anomalies that can be diagnosed earlier withcareful examination.Material and Methods: This was a descriptive study of retrospective data that were obtained from all terminated single pregnancies due toultrasonographic findings of major anomalies from 2011 to 2016 in our department.

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Conclusion & Impact:The study provides valuable information forfuture studies in Turkey and shows the need for an anatomic scan protocol while performing aneuploidy screening during early gestation. (JTurk Ger Gynecol Assoc 2018; 19: 142-5)

🔬Design:Review & Systematic Survey

📍Scope:2011 Verileri

⚙️Variables:Domain Parameters

Abstract

Objective: Fetal structural malformations affect approximately 2-3% of all pregnancies. Only focusing on trisomy screening in first trimesterand deferring the anatomic screening to second trimester may result with late detection of major anomalies that can be diagnosed earlier withcareful examination.Material and Methods: This was a descriptive study of retrospective data that were obtained from all terminated single pregnancies due toultrasonographic findings of major anomalies from 2011 to 2016 in our department. The study was based on a chart review and only abnormalitiesthat were diagnosed before the 16th week were included.Results: Two hundred forty-four first trimester pregnancy terminations were performed. In total, 273 anomalies were detected in the 244patients. Cranial NTD comprised 32% of all anomalies (n=89). Fifteen percent of anomalies (n=41) needed detailed anatomic scanning for earlydiagnosis.Conclusion: In this study, we presented the number and percentage of our early diagnosed anomalies by years, as well showed our diagnosticperformance for specific anomalies such as atrioventricular septal defect during a 5-year period. The study provides valuable information forfuture studies in Turkey and shows the need for an anatomic scan protocol while performing aneuploidy screening during early gestation. (JTurk Ger Gynecol Assoc 2018; 19: 142-5)

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Cite This Article

ARSLAN, E., DEMİR, S. C., MISIRLIOĞLU, S., ÖZSÜRMELİ, M., EVRÜKE, İ. C., SUCU, M., BÜYÜKKURT, S. (2022). Detection of major anomalies during the first and early second trimester: Single-center results of six years. Journal of the Turkish-German Gynecological Association, Cilt: 19 - Sayı: 3, 142–145. https://ajindex.com/articles/567513

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References (9)

Cunningham FG, Leveno KJ, Bloom SL (edts). Williams Obstetrics. (24th edition). New York; USA: McGraw-Hill Education; 2014. p. 283. Pilu G, Nicolaides KH. Standard views for examination of the fetus. In Diagnosis of fetal abnormalities: The 18–23 Weeks Scan. In: Pilu G, Nicolaides KH, editors. London; England: CRC press; 1999. p. 3-4.
Syngelaki A, Chelemen T, Dagklis T, Allan L, Nicolaides KH. Challenges in the diagnosis of fetal non-chromosomal abnormalities at 11-13 weeks. Prenat Diagn 2011; 31: 90-102.
Salomon LJ, Alfirevic Z, Bilardo CM, Chalouhi GE, Ghi T, Kagan KO, et al. ISUOG practice guidelines: performance of first-trimester fetal ultrasound scan. Ultrasound Obstet Gynecol 2013; 41: 102-3.
Luchi C, Schifano M, Sacchini C, Nanini C, Sceusa F, Capriello P, et al. Detailed fetal anatomy assessment in the first trimester at 11, 12 and 13 weeks of gestation. J Matern Fetal Neonatal Med 2012; 25: 675-8.
Farraposo S, Montenegro N, Matias A. Evaluation of the role of firsttrimester obstetric ultrasound in the detection of major anomalies: a systematic review. J Perinat Med 2014; 42: 141-9.
Clur SA, Bilardo CM. Early detection of fetal cardiac abnormalities: how effective is it and how should we manage these patients. Prenat Diagn 2014; 34: 1235-45.
Abu-Rustum RS, Daou L, Abu-Rustum SE. Role of First-trimester sonography in the diagnosis of aneuploidy and structural fetal anomalies. J Ultrasound Med 2010; 29: 1445-52.
Karim JN, Roberts NW, Salomon LJ, Papageorghiou AT. Systematic review of first trimester ultrasound screening in detecting fetal structural anomalies and factors affecting screening performance. Ultrasound Obstet Gynecol 2017; 50: 429-41.
Demianczuk NN, Van Den Hof MC, Farquharson D, Lewthwaite B, Gagnon R, Morin L, et al. The use of first trimester ultrasound. J Obstet Gynaecol Can 2003; 25: 864-75. Hoffman J. The global burden of congenital heart disease. Cardiovasc J Afr 2013; 24: 141-5.