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Journals / Journal of the Turkish-German Gynecological Association / 2022 / Cilt: 23 - Sayı: 1

Comparison of maternal serum NRG-4 levels in healthy and preeclamptic pregnancies

Doğa Fatma ÖCAL
Betül YAKIŞTIRAN
Turhan ÇAĞLAR
Filiz HALICI ÖZTÜRK
Kadriye YAKUT
Fatma Didem YÜCEL YETİŞKİN
Pages
8–13
Publication Date
2022-10-18
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The PE group had higher body mass index, nitrogen urea and creatinine values, and diastolic and systolic blood pressure (p=0.005, p

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The new adipokine, neuregulin-4 (NRG-4), acts as a signaling protein and plays a role in lipogenesis, inflammatory events and atherosclerosis.
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Key Findings & Data:The aim was to investigate maternal levels of NRG-4 in preeclampsia (PE) disease.
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Conclusion & Impact:The PE group had higher body mass index, nitrogen urea and creatinine values, and diastolic and systolic blood pressure (p=0.005, p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: The new adipokine, neuregulin-4 (NRG-4), acts as a signaling protein and plays a role in lipogenesis, inflammatory events and atherosclerosis. The aim was to investigate maternal levels of NRG-4 in preeclampsia (PE) disease. Material and Methods: Pregnant women with PE, divided into severe and mild PE, and gestational age-matched healthy pregnant women, as a control group, were recruited. NRG-4 levels were measured using an ELISA. NRG-4 levels in the groups and the relation between NRG-4 and clinical and laboratory parameters were analyzed. Results: There were 41 women in the PE group, 11 (26.8%) in the severe and 30 (73.2%) in the mild subgroups and 41 controls. There were no significant differences between the groups in terms of maternal age, gravidity, parity, abortion, gestational week at the time of blood sampling, levels of hemoglobin, platelet count, alanine and aspartate transaminases (p=0.067, p=0.819, p=0.957, p=0.503, p=0.054, p=0.217, p=0.306, and p=0.270 respectively). The PE group had higher body mass index, nitrogen urea and creatinine values, and diastolic and systolic blood pressure (p=0.005, p

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Cite This Article

ÖCAL, D. F., YAKIŞTIRAN, B., ÇAĞLAR, T., ÖZTÜRK, F. H., YAKUT, K., YETİŞKİN, F. D. Y. (2022). Comparison of maternal serum NRG-4 levels in healthy and preeclamptic pregnancies. Journal of the Turkish-German Gynecological Association, Cilt: 23 - Sayı: 1, 8–13. https://ajindex.com/articles/567345

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