AI Summary & Key Takeaways
AI InsightWe considered that optimal cut-off values defining significant fibrosis for serum HBV DNA level was 4.5 log10 IU/ml (sensivity:71.8%, specificity:70.9%), for APRI was 0.45 (sensivity:63.4%, specificity: 63.3%), for FIB-4 index was 0.45 (sensivity:64.8%, specificity:64.3%) and lastly for King’s score was 4.00 (sensivity:67.6%, specificity:60.8%).Conclusion: We identified that the scoring systems such as APRI, FIB-4 index and ing’s score are not superior to each other, but serum HBV DNA level is a little better compared with those to predict significiant fibrosis in treatment naive young male patients with non-cirrhotic HBV infection.
📌 3 Key Takeaways
Abstract
Purpose: We aimed to assess serum levels of AST and ALT, platelet counts, INR or serum HBV DNA levels, especially in score systems such as APRI (AST/platelet ratio), FIB-4 index and King’s score, for predicting severity of fibrosis.Material and Methods: One hundred fifty treatment naive male HBV patients underwent percutaneous liver biopsy were evaluated retrospectively. For evaluating the difference in variables and scores, patients were divided into 2 groups such as no or minimal fibrosis group (fibrosis score<2) and significiant fibrosis group (fibrosis score≥2). Results: There were 79 patients (52.7%) with minimal fibrosis and 71 patients (42.3%) with significiant fibrosis. We considered that optimal cut-off values defining significant fibrosis for serum HBV DNA level was 4.5 log10 IU/ml (sensivity:71.8%, specificity:70.9%), for APRI was 0.45 (sensivity:63.4%, specificity: 63.3%), for FIB-4 index was 0.45 (sensivity:64.8%, specificity:64.3%) and lastly for King’s score was 4.00 (sensivity:67.6%, specificity:60.8%).Conclusion: We identified that the scoring systems such as APRI, FIB-4 index and ing’s score are not superior to each other, but serum HBV DNA level is a little better compared with those to predict significiant fibrosis in treatment naive young male patients with non-cirrhotic HBV infection.
Özet
Amaç: Bu çalışmada fibrozis ciddiyetini öngörmede, serum aspartat aminotransferaz (AST) ve alanin aminotransferaz (ALT) seviyeleri, platelet sayısı, INR değeri veya serum Hepatit B virüs (HBV) deoksiribonükleik asit (DNA) seviyelerinin, özellikle AST-platelet oranı (APRI), FIB-4 indeks ve King’s skoru gibi skorlama sistemleri içinde değerlendirilmesi amaçlanmıştır. Gereç ve Yöntem: Yüzelli karaciğer iğne biyopsisi olan tedavi naif erkek HBV hastaları geriye dönük olarak değerlendirildi. Değişkenler arasında farkı değerlendirmek amacıyla, hastalar minimal fibrozisi olanlar (fibrozis skoru<2) ve anlamlı fibrozisi olanlar (fibrozis skoru≥2) olmak üzere iki gruba ayrıldı. Bulgular: Minimal fibrozisi olan 79 hasta (52.7%) ve anlamlı fibrozisi olan 71 hasta (42.3%) vardı. Anlamlı fibrozisi tanımlayan optimal değeri, HBV DNA seviyesi için 4.5 log10 IU/ml (duyarlılık:71.8%, özgüllük:70.9%), APRI için 0.45 (duyarlılık:63.4%, özgüllük:63.3%), FIB-4 indeks için 0.45 (duyarlılık:64.8%, özgüllük:64.3%) ve son olarak King’s skor için 4.00 (duyarlılık: 67.6%, özgüllük:60.8%) olarak belirledik.Sonuç: Tedavi görmemiş sirozu olmayan HBV enfeksiyonu olan erkek hastalarda fibrozis ciddiyetini öngörmede APRI, FIB-4 index ve King’s skorun birbirlerine üstünlüğünün olmadığını, ancak serum HBV DNA seviyelerinin bu skorlara kıyasla biraz daha iyi olduğunu değerlendirmekteyiz.