SavedAdd your journal

Journals / Journal of research in veterinary medicine (Online) / 2019 / Cilt: 38 - Sayı: 2

Effect of Long-Term Centrally Injected Histamine and Its Receptors Antagonist on The Hypothalamic Cyclooxygenase and Lipoxygenase Enzymes in Rats

Burcu ERBAYKENT TEPEDELEN
Ebru YALÇIN
Ayşenur BAŞ
Gökcen GUVENÇ BAYRAM
Burcin ALTINBAŞ
Ebru ÖZYURT
Figen ERSOY
Murat YALCIN
Pages
10–16
Publication Date
2022-10-19
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Central chronic treatments with all three histaminergic receptors antagonists reduced the hypothalamic COX-1 levels andraised the hypothalamic COX-2 and LOX levels.In conclusion, our findings show that the central histamine has a possible role to affect the central COX and LOX pathways.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:The current study was designed to determine the effect of centrally chronic-administrated histamine and histaminergic receptors antagoniston the level of hypothalamic cyclooxygenase (COX) and lipoxygenase (LOX) enzymes.Studies were performed in male Sprague–Dawley rats.
📊
Key Findings & Data:Histamine (100 nmol), histaminergic H1 receptor antagonist chlorpheniramine (100nmol), histaminergic H2 receptor antagonist ranitidine (100 nmol) or histaminergic H3/H4 receptor antagonist thioperamide (100 nmol)was injected intracerebroventricularly for 7 days.
💡
Conclusion & Impact:Central chronic treatments with all three histaminergic receptors antagonists reduced the hypothalamic COX-1 levels andraised the hypothalamic COX-2 and LOX levels.In conclusion, our findings show that the central histamine has a possible role to affect the central COX and LOX pathways.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

The current study was designed to determine the effect of centrally chronic-administrated histamine and histaminergic receptors antagoniston the level of hypothalamic cyclooxygenase (COX) and lipoxygenase (LOX) enzymes.Studies were performed in male Sprague–Dawley rats. Histamine (100 nmol), histaminergic H1 receptor antagonist chlorpheniramine (100nmol), histaminergic H2 receptor antagonist ranitidine (100 nmol) or histaminergic H3/H4 receptor antagonist thioperamide (100 nmol)was injected intracerebroventricularly for 7 days. Central chronic histamine treatment caused increases in the levels of all three enzymes inthe hypothalamus. Central chronic treatments with all three histaminergic receptors antagonists reduced the hypothalamic COX-1 levels andraised the hypothalamic COX-2 and LOX levels.In conclusion, our findings show that the central histamine has a possible role to affect the central COX and LOX pathways. This could beinterpreted as that central histaminergic system might have a potential to activate central COX and LOX pathways to regulate central nervoussystem functions.

🔖

Cite This Article

TEPEDELEN, B. E., YALÇIN, E., BAŞ, A., BAYRAM, G. G., ALTINBAŞ, B., ÖZYURT, E., ERSOY, F., YALCIN, M. (2022). Effect of Long-Term Centrally Injected Histamine and Its Receptors Antagonist on The Hypothalamic Cyclooxygenase and Lipoxygenase Enzymes in Rats. Journal of research in veterinary medicine (Online), Cilt: 38 - Sayı: 2, 10–16. https://ajindex.com/articles/566253

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (17)

  1. Haas HL, Sergeeva OA, Selbach O. Histamine in the Nervous System. Physiol Rev. 2008;88:1183–1241
  2. Brown RE, Stevens DR, Haas HL. The physiology of brain histamine. Prog Neurobiol. 2001;63:637–672
  3. Yalcin M, Savci V. J. Jochem Involvement of the cholinergic system in the central histamine-induced reversal of critical haemorrhagic hypotension in rats J Physiol Pharmacol. 2009;60:133-137
  4. Altinbas B, Yilmaz MS, Savci V, et al. Centrally injected histamine increases posterior hypothalamic acetylcholine release in hemorrhage-hypotensive rats. Auton Neurosci. 2015;187:63–69
  5. Altinbas B, Guvenc G, Erkan LG, et al. Histamine restores hemorrhage induced hypotension by activating cholinergic neurons in nucleus tractus solitarius. Brain Res. 2016;1649:132–140
  6. Schwartz JC, Arrang JM, Garbarg M, et al. Histaminergic transmission in the mammalian brain. Physiol Rev. 1991;71:1–51
  7. Bugajski J, Janusz Z. Central histaminergic stimulation of pituitary-adrenocortical response in the rat. Life Sci. 1983;33:1179–1189
  8. Knigge U, Warberg J. Neuroendocrine functions of histamine. Agents Actions Suppl. 1991;33:29-53
  9. Kjaer A, Larsen PJ, Knigge U, et al. Histaminergic activation of the hypothalamic-pituitary-adrenal axis. Endocrinology. 1994;135:1171-1177
  10. Kjaer U, Knigge FW, Bach J, et al. Histamine- and stress-induced secretion of ACTH and beta-endorphin: involvement of corticotropin-releasing hormone and vasopressin. Neuroendocrinology. 1992;56:419- 428
  11. Mitsuma T, De Heng S, Nogimori T, et al. Effect of histamine and its blockers on plasma beta-endorphin-like immunoreactivity in rats. Endocrinol Exp. 1987;21:95-102
  12. Knigge UP. Histaminergic regulation of prolactin secretion. Dan Med Bull. 1990;37:109-124
  13. Radacs M, Galfi M, Juhasz A, et al. Histamine-induced enhancement of vasopressin and oxytocin secretion in rat neurohypophyseal tissue cultures. Regul Pept. 2006;134:82-88
  14. Knigge U, Warberg J. The role of histamine in the neuroendocrine regulation of pituitary hormone secretion. Acta Endocrinol. 1991;124:609–619
  15. Niaz N, Guvenc G, Altinbas B, et al. Intracerebroventricular injection of histamine induces the hypothalamic-pituitary-gonadal axis activation in male rats. Brain Res. 2018;1699:150-157
  16. Jochem J. Cardiovascular effects of histamine administered intracerebroventricularly in critical haemorrhagic hypotension in rats. J Physiol Pharmacol. 2000;51:229–239
  17. Jochem J. Central histamine-induced reversal of haemorr