SavedAdd your journal

Journals / Cukurova Medical Journal / 2019 / Cilt: 44 - Sayı: 1

The role of mean platelet volume and ischemia modified albumin levels in early periods of acute mesenteric ischemia: an experimental study

Akut mesenterik iskeminin erken dönemlerinde ortalama platelet hacmi ve iskemi modifiye albümin düzeylerinin rolü: bir deneysel çalışma

Güvenç CANTİLAV
Tuna BİLECİK
Nurullah BÜLBÜLLER
Pages
154–159
Publication Date
2019-03-31
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Further clinical studies are required to define the role of these parameters in early diagnosis of AMI since AMI is a highly mortal disease if not diagnosed promptly

📌 3 Key Takeaways

🎯
Objective & Hypothesis:The aim of this study was to determine the role of mean platelet volume (MPV) and ischemia modified albumin (IMA) in early diagnosis of acute mesenteric ischemia (AMI).Materials and Methods: In this study, 18 Wistar Albino rats were randomly assigned to 3 experimental groups with 6 rats in each group as; sham group without laparotomy, control group with laparotomy and mesenteric ischemia-induced group.
📊
Key Findings & Data:Platelet count, MPV and IMA were studied at the end of the 120th min of superior mesenteric artery obstruction in AMI group and at the same time in other groups.
💡
Conclusion & Impact:Conclusion: Further clinical studies are required to define the role of these parameters in early diagnosis of AMI since AMI is a highly mortal disease if not diagnosed promptly
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Akut mezenter iskemi · Ortalama trombosit hacmi · İskemi modifiye albumin

Abstract

The aim of this study was to determine the role of mean platelet volume (MPV) and ischemia modified albumin (IMA) in early diagnosis of acute mesenteric ischemia (AMI).Materials and Methods: In this study, 18 Wistar Albino rats were randomly assigned to 3 experimental groups with 6 rats in each group as; sham group without laparotomy, control group with laparotomy and mesenteric ischemia-induced group. Platelet count, MPV and IMA were studied at the end of the 120th min of superior mesenteric artery obstruction in AMI group and at the same time in other groups. Results: In AMI group MPV and IMA values were significantly higher compared with other 2 groups, while platelet count was significantly lower . There was not any statistically significant difference between control and sham groups regarding these parameters. Conclusion: Further clinical studies are required to define the role of these parameters in early diagnosis of AMI since AMI is a highly mortal disease if not diagnosed promptly

Özet

Amaç: Bu çalışmanın amacı akut mezenterik sikeminin (AMİ) erken tanısında ortalama trombosit hacminin (MPV) ve iskemi modifiye albümin (IMA) dğzeylerinin rolünü belirlemekti.Gereç ve Yöntem: Bu çalışmada, 18 Wistar Albino cinsi sıçan, her grupta 6 sıçan olacak şekilde 3 deney grubuna rasgele olarak ayrıldı; laparotomisiz şam grubu, laparotomi yapılan control grubu ve mezenterik iskemi grubu. Trombosit sayısı, MPV ve IMA, AMI grubunda 120. dk.lık superior mezenterik arter tıkanıklığının sonunda ve aynı zamanda diğer gruplarda çalışıldı.Bulgular: AMI grubunda MPV ve IMA değerleri diğer 2 gruba göre anlamlı derecede yüksekti; trombosit sayısı anlamlı olarak düşüktü. Kontrol ve şam grupları arasında bu parametreler açısından istatistiksel olarak anlamlı bir fark yoktu.Sonuç: AMI hızlı tanı konulmazsa oldukça mortal olabilen bir hastalıktır. Bu nedenle erken tanıda bu parametrelerin rolünü tanımlamak için daha fazla klinik çalışma gereklidir.

🔖

Cite This Article

CANTİLAV, G., BİLECİK, T., BÜLBÜLLER, N. (2019). The role of mean platelet volume and ischemia modified albumin levels in early periods of acute mesenteric ischemia: an experimental study. Cukurova Medical Journal, Cilt: 44 - Sayı: 1, 154–159. https://ajindex.com/articles/56482

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (14)

  1. Bala M, Kashuk J, Moore EE, Kluger Y, Biffl W, Gomes CA, Ben-Ishay O et al. Acute mesenteric ischemia: guidelines of the World Society of Emergency Surgery.World J Emerg Surg. 2017;7;12:38
  2. Resch TA, Acosta S, and Sonesson B. Endovascular techniques in acute arterial mesenteric ischemia. Semin Vasc Surg. 2010;23:29-35
  3. Kassahun WT, Schulz T, Richter O, Hauss J. Unchanged high mortality rates from acute occlusive intestinal ischemia: six year review. Langenbecks Arch Surg. 2008;393:163-71
  4. Acosta S. Mesenteric ischemia.Curr Opin Crit Care. 2015;21:171-8
  5. Kim HK, Hwang D, Park S, Huh S, Lee JM, Yun WS et al. Effect of clinical suspicion by referral physician and early outcomes in patients with acute superior mesenteric artery embolism. Vasc Specialist Int. 2017;33:99-107
  6. Ierardi AM, Tsetis D, Sbaraini S, Angileri SA, Galanakis N, Petrillo M et al. The role of endovascular therapy in acute mesenteric ischemia. Ann Gastroenterol. 2017;30:526-33
  7. Kirkpatrick ID, Kroeker MA, Greenberg HM. Biphasic CT with mesenteric CT angiography in the evaluation of acute mesenteric ischemia: initial experience. Radiology. 2003;229:91-8
  8. Lehtimäki TT, Kärkkäinen JM, Saari P, Manninen H, Paajanen H, Vanninen R. Detecting acute mesenteric ischemia in CT of the acute abdomen is dependent on clinical suspicion: Review of 95 consecutive patients. Eur J Radiol. 2015;84:2444-53
  9. Evennett NJ, Petrov MS, Mittal A, Windsor JA. Systematic review and pooled estimates for the diagnostic accuracy of serological markers for intestinal ischemia. World J Surg. 2009;33:1374-83
  10. Cudnik MT, Darbha S, Jones J, Macedo J, Stockton SW, Hiestand BC. The diagnosis of acute mesenteric ischemia: A systematic review and meta-analysis. Acad Emerg Med. 2013;20:1087-100
  11. Mezouar S, Frere C, Darbousset R, Mege D, Crescence L, Dignat-George F et al. Role of platelets in cancer and cancer-associated thrombosis: Experimental and clinical evidences. Thromb Res. 2016;139:65-76
  12. Riedl J, Kaider A, Reitter EM, Marosi C, Jäger U, Schwarzinger I, et al. Association of mean platelet volume with risk of venous thromboembolism and mortality in patients with cancer. Results from the Vienna Cancer and Thrombosis Study (CATS). Thromb Haemost. 2014;111:670-8
  13. Bar-Or D, Lau E, Winkler JV. A novel assay for cobalt-albumin binding and its potential as a marker for myocardial ischemia-a preliminary report. J Emerg Med. 2000;19:311-5
  14. Sbarouni E, Georgiadou P, Voudris V. Ischemia mo