Journals / Journal of Mood Disorders / 2013 / Cilt: 3 - Sayı: 2

Akut stres reaksiyonu ile ilişkili olarak intihar giri- şiminde bulunan hastalarda lökosit ve trombosit aktiviteleri üzerine bir çalışma

A Study of Leukocyte and Platelet Activity in Patients with Suicide Attempt Related to Acute Stres Reaction

Pages
52–57
Publication Date
2022-10-18
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Atfollow-up, the platelet count was lower in patients than incontrols (p= 0.001), which was related to suicide attempts byusing anti-depressants (p= 0.003).Conclusion: ASR did not increase platelet count or MPV, butwe found an increase in leukocyte counts following ASR.Additionally, our study supported the antiplatelet effect ofantidepressant medications.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: Acute stress reaction (ASR) is often seen with depression,and stress-related hormones may play an important role inacute arterial thrombosis by increasing platelet aggregation.
📊
Key Findings & Data:Using a case- control design, we examined 30 suicide cases and 33 controlsmatched for gender and age.Results: The 30 subjects diagnosed with ASR related suicideshowed increased white blood cell counts but similar plateletcounts and mean platelet volume compared with controls.
💡
Conclusion & Impact:Atfollow-up, the platelet count was lower in patients than incontrols (p= 0.001), which was related to suicide attempts byusing anti-depressants (p= 0.003).Conclusion: ASR did not increase platelet count or MPV, butwe found an increase in leukocyte counts following ASR.Additionally, our study supported the antiplatelet effect ofantidepressant medications.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: Acute stress reaction (ASR) is often seen with depression,and stress-related hormones may play an important role inacute arterial thrombosis by increasing platelet aggregation. Tothe best of our knowledge, no study has examined leukocyteand platelet counts following a suicide attempt with ASR.Method: The present study examined blood leukocyte, plateletand mean platelet volume (MPV) levels. In addition, weexamined the factors affecting these parameters. Data forpatients who were admitted to the emergency room andevaluated by same psychiatrist after a suicide attempt wereobtained from the health registries. Controls were selectedfrom all residents living in the same area. Using a case- control design, we examined 30 suicide cases and 33 controlsmatched for gender and age.Results: The 30 subjects diagnosed with ASR related suicideshowed increased white blood cell counts but similar plateletcounts and mean platelet volume compared with controls. Atfollow-up, the platelet count was lower in patients than incontrols (p= 0.001), which was related to suicide attempts byusing anti-depressants (p= 0.003).Conclusion: ASR did not increase platelet count or MPV, butwe found an increase in leukocyte counts following ASR.Additionally, our study supported the antiplatelet effect ofantidepressant medications.

Özet

Amaç: Akut stres reaksiyonu (ASR) sıklıkla depresyonla birliktegörülür ve stresle ilişkili hormonlar trombosit birikimiyle ilişkiliarteriyel trombozda önemli rol oynarlar. Bilgimize göre ASRile ilişkili bir intihar girişimi sonrasında lökosit ve trombositsayımını değerlendiren çalışma yoktur. Yöntem: Bu çalışmada kan lökosit, trombosit ve ortalamatrombosit hacim (MPV) düzeyleri incelendi. İlave olarak, buparametreleri etkileyen etmenler değerlendirildi. Acile başvuran ve intihar girişimi sonrasında aynı psikiyatrist tarafındandeğerlendirilen hastalara ait veriler toplandı. Aynı bölgedeyaşayan sağlıklı örneklem grubu kontrol grubu olarak kabuledildi. Vaka-kontrol çalışması olarak dizayn edilen bu çalışmada 30 intihar girişimi vakası ve yaş ve cinsiyet olarak uygun 33kontrol vakası analize tabi tutuldu. Bulgular: İntiharla ilişkili ASR tanısı olan 30 kişinin kontrollerle karşılaştırılmasında kan sonuçları artmış lökosit düzeyisaptanırken trombosit sayısı ve MPV düzeyleri benzer bulundu. Takipte, trombosit düzeyi hasta grubunda daha düşükdüzeylerde bulundu (p=0.001) ve bu düşüklük intihar amaçlıantidepresan kullanımı ile ilişkiliydi (p=0.003).Sonuç: ASR sonrasında trombosit sayısı veya MPV düzeyiartmadı, fakat lökosit sayısında artış gözlemlendi. İlaveten,çalışmamız antidepresan ilaçlarla ilişkili anti-trombosit etkininvarlığını da desteklemekteydi.

🔖

Cite This Article

ALÇELİK, A., KOÇER, A., KOÇER, E., KOCAMAN, G. (2022). Akut stres reaksiyonu ile ilişkili olarak intihar giri- şiminde bulunan hastalarda lökosit ve trombosit aktiviteleri üzerine bir çalışma. Journal of Mood Disorders, Cilt: 3 - Sayı: 2, 52–57. https://ajindex.com/articles/564651

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (13)

  1. World Health Organization. The ICD-10 classification of mental and behavioral disorders: diagnostic criteria for research. Geneva: World Health Organization, Division of Mental Health, 1993
  2. Okulate GT. Suicide attempts in a Nigerian military setting. East Afr Med J. 2001;78:493-6
  3. Kim CK, McGorray SP, Bartholomew BA, Marsh M, Dicken T, Wassertheil-Smoller S, Curb JD, Oberman A, Hsia J, Gardin J, Wong ND, Barton B, McMahon RP, Sheps DS. Depressive symptoms and heart rate variability in postmenopausal women. Arch Intern Med. 2005;165:1239-44
  4. Gradus JL, Qin P, Lincoln AK, Miller M, Lawler E, Sørensen HT, Lash TL. Acute stress reaction and completed suicide. Int J Epidemiol. 2010;39:1478-84
  5. Maes M, Van Bockstaele DR, Gastel A, Song C, Schotte C, Neels H, DeMeester I, Scharpe S, Janca A. The effects of psychological stress on leukocyte subset distribution in humans: evidence of immune activation. Neuropsychobiology. 1999;39:1-9
  6. Ots I, Murumagi A,Horak P. Haematological health state indices of reproducing Great Tits: methodology and sources of natural variation. Functional Ecology. 1998;12:700-7
  7. Davis AK, Maney DL, Maerz JC. The use of leukocyte profiles to measure stress in vertebrates: a review for ecologists. Funct. Ecol. 2008;22:760-72
  8. Williams L. Depression and Stroke: Cause or Consequence ? Semin Neurol. 2005;25:396-409
  9. Serebruany VL, Glassman AH, Malinin AI, Nemeroff CB, Musselman DL, van Zyl LT, Finkel MS, Krishnan KR, Gaffney M, Harrison W, Califf RM, O’Connor CM. Sertraline AntiDepressant Heart Attack Randomized Trial Study Group. Platelet/endothelial biomarkers in depressed patients treated with the selective serotonin reuptake inhibitor sertraline after acute coronary events: the Sertraline AntiDepressant Heart Attack Randomized Trial (SADHART) Platelet Substudy. Circulation. 2003;108:939-44
  10. Ataoglu A, Canan F. Mean platelet volume in patients with major depression: effect of escitalopram treatment. J Clin Psychopharmacol. 2009;29:368-71
  11. Pozzi AO, Bernardo E, Coronado MT, Punchard MA, González P, Fantidis P. Acute arterial thrombosis in the absence of inflammation: the stress-related anti-inflammatory hormone ACTH participates in platelet-mediated thrombosis. Atherosclerosis. 2009;204:79-84
  12. Yetkin E. Mean platelet volume not so far from being a routine diagnostic and prognostic measurement. Thromb Haemost. 2008;100:3-4
  13. Muscari A, De Pascalis S, Cenni A, Ludovico C, Castaldini N, Antonelli S, Bian