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Journals / Cukurova Medical Journal / 2019 / Cilt: 44 - Sayı: 4

Relationship between umbilical cord blood vitamin D levels and thymus size in healthy and term newborns

Sağlıklı term yenidoğanlarda umbilikal kord kanında D vitamini düzeylerinin timus büyüklüğü ile ilişkisi

Selvi GÜLAŞI
Mustafa Kurthan MERT
Gökhan SÖKER
Ümit ÇELİK
Pages
1450–1455
Publication Date
2019-12-29
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

No difference was observed between the thymic index measurements and maternal vitamin D use and cord blood vitamin D level.Conclusion: There was no relationship between cord blood vitamin D level and thymus size.

📌 3 Key Takeaways

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Objective & Hypothesis:Purpose: Thymus is a primary lymphoid organ which contains the vitamin D receptor.
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Key Findings & Data:The aim of this study was to determine the relationship between cord blood 25-hydroxy vitamin D levels and thymus size.Materials and Methods: 149 babies were included in the present study.
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Conclusion & Impact:No difference was observed between the thymic index measurements and maternal vitamin D use and cord blood vitamin D level.Conclusion: There was no relationship between cord blood vitamin D level and thymus size.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:yenidoğan · timus · ultrasonografi

Abstract

Purpose: Thymus is a primary lymphoid organ which contains the vitamin D receptor. Vitamin D has an immunological regulatory effect on the adaptive and innate immune system. The aim of this study was to determine the relationship between cord blood 25-hydroxy vitamin D levels and thymus size.Materials and Methods: 149 babies were included in the present study. The cord blood 25-hydroxy vitamin D level was measured. Mothers’ and infants’ features were recorded. Thymus volume were evaluated with ultrasonography. The thymic index and thymus/weight index were calculated. Results: In the case of irregular use or non-use of maternal vitamin D, the likelihood of vitamin D deficiency in the cord blood was higher. No difference was observed between the thymic index measurements and maternal vitamin D use and cord blood vitamin D level.Conclusion: There was no relationship between cord blood vitamin D level and thymus size.

Özet

Amaç: Timus vitamin D reseptörü içeren primer bir lenfoid organdır. D vitamini adaptif ve doğal immün system üzerine düzenleyici etkilere sahiptir. Bu çalışmanın amacı kord kanı 25-hidroksi vitamin D düzeyi ile timus büyüklüğü arasındaki ilişkiyi tanımlamaktır.Gereç ve Yöntem: Çalışmaya 149 bebek alındı. Kord kanı 25-hidroksi vitamin D düzeyleri ölçüldü. Annelerin ve bebeklerin özellikleri kaydedildi. Timus büyüklüğü ultrasonografi ile değerlendirildi. Timik indeks ve timus/ağırlık indeksi hesaplandı.Bulgular: Annenin D vitaminini düzensiz kullanması veya kullanmaması durumunda kord kanında D vitamin eksikliği olasılığını daha yüksekti. Timik indeks ile annenin vitamin kullanımı ve kord kanı D vitamini düzeyi ile timik indeks arasında ilişki saptanmadı.Sonuç: Kord kanı D vitamini düzeyi ile timik indeks arasında ilişki saptanmamıştır.

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Cite This Article

GÜLAŞI, S., MERT, M. K., SÖKER, G., ÇELİK, Ü. (2019). Relationship between umbilical cord blood vitamin D levels and thymus size in healthy and term newborns. Cukurova Medical Journal, Cilt: 44 - Sayı: 4, 1450–1455. https://ajindex.com/articles/56355

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References (15)

  1. Hossein-Nezhad A, Mirzaei K, Keshavarz SA, Ansar H, Saboori S, Tootee A. Evidences of dual role of vitamin D through cellular energy homeostasis and inflammation pathway in risk of cancer in obese subjects. Minerva Med. 2013;104:295-307
  2. Gonzalez-Molero I, Rojo-Martinez G, Morcillo S, Gutierrez C, Rubio E, Pérez-Valero V et al. Hypovitaminosis D and incidence of obesity: a prospective study. Eur J Clin Nutr. 2013;67:680-2
  3. Sloka S, Silva C, Wang J, Yong VW. Predominance of Th2 polarization by vitamin D through a STAT6- dependent mechanism. J Neuroinflammation. 2011;8:56
  4. Masri OA, Chalhoub JM, Sharara AI. Role of vitamins in gastrointestinal diseases. World J Gastroenterol. 2015;21:5191-209
  5. Dağdeviren-Çakır A, Arvas A, Barut K, Gür E, Kasapçopur Ö. Serum vitamin D levels during activation and remission periods of patients with juvenile idiopathic arthritis and familial Mediterranean fever. Turk J Pediatr. 2016;58:125-31
  6. Deluca HF, Cantorna MT. Vitamin D: its role and uses in immunology. FASEB J. 2001;15:2579-85
  7. Veldman CM, Cantorna MT, DeLuca HF. Expression of 1,25-dihydroxyvitamin D(3) receptor in the immune system. Arch Biochem Biophys. 2000; 374:334-8
  8. Schauber J, Dorschner RA, Coda AB, Büchau AS, Liu PT, Kiken D et al. İnjury enhances TLR2 function and antimicrobial peptide expression through a vitamin Ddependent mechanism. J Clin Invest. 2007;117:803- 11
  9. Liu PT, Stenger S, Li H, Wenzel L, Tan BH, Krutzik SR et al. Toll-like receptor triggering of a vitamin Dmediated human antimicrobial response. Science. 2006;311:1770-3
  10. Clancy N, Onwuneme C, Carroll A, McCarthy R, McKenna MJ, Murphy N et al. Vitamin D and neonatal immune function. J Matern Fetal Neonatal Med. 2013;26:639-46
  11. Sadeghi K, Wessner B, Laggner U, Ploder M, Tamandl D, Friedl J et al. Vitamin D3 downregulates monocyte TLR expression and triggers hyporesponsiveness to pathogen-associated molecular patterns. Eur J Immunol. 2006;36:361-70
  12. Youssef DA, Miller CW, El-Abbassi AM, Cutchins DC, Cutchins C, Grant WB et al. Antimicrobial implications of vitamin D. Dermatoendocrinol. 2011;3:220-9
  13. Savino W. The thymus gland is a target in malnutrition. Eur J Clin Nutr. 2002;56:46-49
  14. Varga I, Pospisilova V, Gmitterova K, Galfiova P, Polak S,Galbavy S et al. The phylogenesis and ontogenesis of the human pharyngeal region focused on the thymus, parathyroid, and thyroid glands. Neuroendcrinol Lett. 2008;29:837-45
  15. Staal FJ, Weerkamp F, Langerak AW, He