Journals / Cukurova Medical Journal / 2019 / Cilt: 44 - Sayı: 4

Relation of complete blood count parameters and derivatives with radiologic staging of knee osteoarthritis

Diz osteoartriti radyolojik evrelemesi ile tam kan sayım parametreleri ve türevleri ilişkisi

Pages
1364–1370
Publication Date
2019-12-29
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In the future, these parameters may be used as a guide to OA progression.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Purpose: In this study, the relationship between radiologic progression and complete blood count parameters and derivatives, which have appeared as biomarkers for systemic inflammation in recent years, were evaluated in patients with knee osteoarthritis (OA).
📊
Key Findings & Data:Materials and Methods: This retrospective study included 209 consecutive patients 40 to 80 years of age diagnosed with knee OA according to 2010 American College of Rheumatology clinical criteria.
💡
Conclusion & Impact:In the future, these parameters may be used as a guide to OA progression.
🔬Design:Research Article
📍Scope:2010 Verileri
⚙️Variables:Osteoartrit · inflamasyon · inflamatuar belirteçler

Abstract

Purpose: In this study, the relationship between radiologic progression and complete blood count parameters and derivatives, which have appeared as biomarkers for systemic inflammation in recent years, were evaluated in patients with knee osteoarthritis (OA). Materials and Methods: This retrospective study included 209 consecutive patients 40 to 80 years of age diagnosed with knee OA according to 2010 American College of Rheumatology clinical criteria. Participants’ demographic characteristics, complete blood parameters and derivatives were recorded. Blood platelet to lymphocyte ratio (PLR), neutrophil to lymphocyte ratio (NLR), and monocyte to neutrophil ratio (MNR) levels were calculated. Results: The majority of patients with high-grade knee OA were determined to be females of an advanced agewith higher patellar tendon length (PTL). Their leukocyte (WBC), neutrophil, and NLR levels were significantly higher than others. When we compared this group of patients to four groups (grades 1-4), advanced age, female gender, PTL, Q angle, WBC, neutrophils, mean platelet volume (MPV), and NLR were significantly higher in patients with grade 4 knee OA. Conclusion: In advanced knee OA, patellofemoral Q angle and PTL increased along with serum WBC, neutrophil, NLR, and MPV levels while RBC, Hb, lymphocyte, monocyte, basophil, and eosinophil levels were reduced. In the future, these parameters may be used as a guide to OA progression.

Özet

Amaç: Bu çalışmada diz osteoartritli (OA) hastalarda, son yıllarda sistemik inflamasyon için biyobelirteç olarak ortaya çıkan, tam kan sayımı parametre ve türevleri ile radyolojik ilerleme arasındaki ilişki değerlendirildi. Gereç ve Yöntem: Bu retrospektif çalışma 2010 Amerikan Romatoloji Koleji klinik kriterlerine göre diz OA tanısı konmuş 40 ila 80 yaşları arasındaki 209 ardışık hastayı içermektedir. Katılımcıların demografik özellikleri, tam kan parametreleri ve türevleri kaydedildi. Kan trombosit / lenfosit oranı (PLR), nötrofil / lenfosit oranı (NLR) ve monosit / nötrofil oranı (MNR) seviyeleri hesaplandı.Bulgular: Yüksek dereceli diz OA'sı olan hastaların çoğunluğunun, ileri yaşta, artmış patellar tendon uzunluğu (PTL) olan kadın olduğu belirlendi. Lökosit (WBC), nötrofil ve NLR düzeyleri diğer hastalardan anlamlı derecede yüksekti. Bu hasta grubunu dört gruba (örn. evre 1-4 arası) ayırdığımızda, 4. evre diz OA'lı hastalarda ileri yaş, kadın cinsiyet, PTL, Q açısı; WBC, nötrofiller ortalama trombosit hacmi (MPV) ve NLR anlamlı olarak yüksek bulundu.Sonuç: İleri diz OA olgularında patellofemoral Q açısı ve PTL, serum WBC, nötrofil, NLR ve MPV ile birlikte artmış; RBC, Hb, lenfosit, monosit, bazofil ve eozinofil düzeyleri azalmıştır. Gelecekte, bu parametreler hastalığın ilerlemesinde bir rehber olarak kullanılabilir.

🔖

Cite This Article

KOCA, T. T., BAYKARA, M., KOÇYİĞİT, B. F. (2019). Relation of complete blood count parameters and derivatives with radiologic staging of knee osteoarthritis. Cukurova Medical Journal, Cilt: 44 - Sayı: 4, 1364–1370. https://ajindex.com/articles/56343

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (16)

  1. Zhai G, Randell EW, Rahman P. Metabolomics of osteoarthritis: emerging novel markers and their potential clinical utility. Rheumatology(Oxford). 2018
  2. 95 2. Taşoğlu Ö, Bölük H, Şahin Onat Ş, Taşoğlu İ, Özgirgin N. Is blood neutrophil-lymphocyte ratio an independent predictor of knee osteoarthritis severity? Clin Rheumatol. 2016
  3. Aktürk S, Büyükavcı R. Evaluation of blood neutrophil-lymphocyte ratio and platelet distribution width as inflammatory markers in patients with fibromyalgia. Clin Rheum 2017
  4. Fang Y-N, Tong M-S, Sung P-H, Chen YL, Chen CH, Tsai NW, et al. Higher neutrophil counts and neutrophil-to-lymphocyte ratio predict prognostic outcomes in patients after non-atrial fibrillationcaused ischemic stroke. Biomed J. 2017
  5. 154–62. 5. Gundogdu Meydaneri G, Meydaneri S. Can neutrophil lymphocyte ratio predict the likelihood of suicide in patients with major depression? Cureus. 2018
  6. e2510. 6. Koca TT, Arslan A, Özdemir FÇ, Berk E. The importance of red cell distribution width and neutrophil-lymphocyte ratio as a new biomarker in rheumatoid arthritis. Eur Res J. 2019
  7. Petersson IF, Boegård T, Saxne T, Silman AJ, Svensson B. Radiographic osteoarthritis of the knee classified by the Ahlbäck and Kellgren & Lawrence systems for the tibiofemoral joint in people aged 35- 54 years with chronic knee pain. Ann. Rheum. Dis. 1997
  8. Kellgren JH, Lawrence JS. Radiological assessment of osteo-arthrosis. Ann Rheum Dis 2000
  9. Raveendranath R, Shankar N, Narayanan S, Ranganath P, Devi R. Bilateral variability of the quadriceps angle (q angle) in an adult indian population. Iran J Basic Med Sci. 2011
  10. 465–71. 10. Lu W, Yang J, Chen S, Zhu Y, Zhu C. Abnormal Patella Height based on Insall-salvati ratio and its correlation with patellar cartilage lesions: an extremity-dedicated low-field magnetic resonance imaging analysis of 1703 chinese cases. Scand J Surg. 2016
  11. Pereira D, Ramos E, Branco J. Osteoarthritis. Acta Med Port. 2015
  12. Pavelka K. Osteoarthritis as part of metabolic syndrome? Vnitr Lek. 2017
  13. Urban H, Little CB. The role of fat and inflammation in the pathogenesis and management of osteoarthritis. Rheumatology (Oxford). 2018
  14. Patra D, Sandell LJ. Evolving biomarkers in osteoarthritis. J Knee Surg. 2011
  15. Rousseau JCh, Garnero P. Biological markers in osteoarthritis. Bone. 2012
  16. Wang X, Oo WM, Linklat