Journals / Cukurova Medical Journal / 2019 / Cilt: 44 Sayı: Ek 1

Role of whole blood markers in carbon monoxide poisoning

Karbonmonoksit zehirlenmesinde tam kan belirteçlerinin rolü

Pages
197–201
Publication Date
2019-12-29
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

However, there was no significant correlation between patient admission time and Glaskow Coma Scale (GCS), carboxyhemoglobin (COHb), RDW, NLR and PLR levels.Conclusion: Our study suggested that RDW, NLR and PLR levels have potential to be a useful marker for the diagnosis of CO poisoning.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Purpose: Carbon monoxide (CO) poisoning is one of the most common causes of fatal suicide or accidental poisoning worldwide.
📊
Key Findings & Data:Therefore, the role of whole blood parameters in CO poisoning was investigated.Material and Methods: A total of 442 patients diagnosed with CO intoxication at the emergency department between January 1, 2014 and January 1, 2016 were included in the study retrospectively.
💡
Conclusion & Impact:However, there was no significant correlation between patient admission time and Glaskow Coma Scale (GCS), carboxyhemoglobin (COHb), RDW, NLR and PLR levels.Conclusion: Our study suggested that RDW, NLR and PLR levels have potential to be a useful marker for the diagnosis of CO poisoning.
🔬Design:Research Article
📍Scope:2014 Verileri
⚙️Variables:Karbonmonoksit · nötrofil lenfosit oranı · platelet lenfosit oranı

Abstract

Purpose: Carbon monoxide (CO) poisoning is one of the most common causes of fatal suicide or accidental poisoning worldwide. There is no specific biomarker in the diagnosis. Therefore, the role of whole blood parameters in CO poisoning was investigated.Material and Methods: A total of 442 patients diagnosed with CO intoxication at the emergency department between January 1, 2014 and January 1, 2016 were included in the study retrospectively. The demographic characteristics of the patient group and the complete blood results were obtained from the hospital registry system. The control group consisted of 100 patients presenting with similar complaints to the emergency department. Leukocyte (WBC), red cell distribution width (RDW), platelet, lymphocyte, neutrophil, neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) values of both groups were compared statistically.Results: The patient and control groups were similar in age and gender. The WBC, RDW, Platelet, Lymphocyte, Neutrophil, NLR and PLR levels of the patient group were significantly higher compared to the control group. However, there was no significant correlation between patient admission time and Glaskow Coma Scale (GCS), carboxyhemoglobin (COHb), RDW, NLR and PLR levels.Conclusion: Our study suggested that RDW, NLR and PLR levels have potential to be a useful marker for the diagnosis of CO poisoning.

Özet

Amaç: Karbonmonoksit (CO) zehirlenmesi dünya çapındaki ölümcül intihar veya kazara zehirlenmelerin en yaygın nedenlerinden birisidir. Tanısında spesifik bir biyobelirteç yoktur. Bu sebeple çalışmada CO zehirlenmesinde tam kan parametreleri’nin rolü araştırılmıştır.Gereç ve Yöntem: Çalışmada 1 Ocak 2014 – 1 Ocak 2016 tarihleri arasında acil serviste CO zehirlenmesi tanısı alan ve dışlama kriterlerini sağlayan toplam 442 hasta retrospektif olarak incelendi. Hasta grubunun demografik özellikleri ve tam kan sonuçlarına hastane kayıt sisteminden ulaşıldı. Kontrol grubu acil servise benzer şikâyetler ile başvuran 100 hastadan oluşturuldu. Her iki grubun lökosit (WBC), kırmızı hücre dağılım genişliği (RDW), platelet, lenfosit, nötrofil, nötrofil-lenfosit oranı (NLR) ve platelet-lenfosit oranı (PLR) değerleri istatistiksel olarak karşılaştırıldı. Bulgular: Hasta ve kontrol grubu yaş ve cinsiyet bakımından birbirleri ile benzerdi. Hasta grubunun WBC, RDW, Platelet, Lenfosit, Nötrofil, NLR ve PLR değerleri kontrol grubu ile kıyaslandığında anlamlı derece yüksek bulundu. Ancak hasta yatış süreleri ile Glaskow Koma Skalası (GKS), karboksihemoglobin (COHb), RDW, NLR ve PLR düzeyleri arasında anlamlı bir korelasyon bulunmamıştır.Sonuç: Çalışmamız RDW, NLR ve PLR düzeylerinin CO zehirlenmesi tanısını öngörmede kullanılabilir bir biyobelirteç olma potansiyeli olduğunu düşündürmüştür.

🔖

Cite This Article

ERTEKİN, B., KOÇAK, S., ACAR, T., ÖZTÜRK, E., DEMİR, L. S. (2019). Role of whole blood markers in carbon monoxide poisoning. Cukurova Medical Journal, Cilt: 44 Sayı: Ek 1, 197–201. https://ajindex.com/articles/56273

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (7)

  1. Raub JA, Mathiue-Nolf M, Hampson NB, Thom SR. Carbon mon¬oxide poisoning-a public health perspective. Toxicology 2000;145:1-14
  2. Weaver LK. Carbon monoxide poisoning. Crit Care Clin 1999;15:297-317 3. Zahorec. Ratio of neutrophil to lymphocyte counts - rapid and simple parameter of systemic inflammation and stress in critically ill. Bratisl Lek Listy. 2001;102:5–14
  3. Sönmez O, Ertas‚ G, Bacaksız A, Tasal A, Erdogan E, Asoglu E et al. Relation of neutrophil-to-lymphocyte ratio with the presence and complexity of coronary artery disease, An observational study. Anatolian Journal of Cardiology 2013;13:662-7 5. Dundar ZD, Ergin M, Koylu R, Ozer R, Cander B, Gunaydin YK. Neutrophil-lymphocyte ratio in patients with pesticide poisoning. J Emerg Med. 2014;47:286-93 6. Kara H, Degirmenci S, Bayir A, Ak A, Akinci M, Dogru A et al. Red cell distribution width and neurological scoring systems in acute stroke patients. Neuropsychiatr Dis Treat. 2015;11:733-9 7. Dündar Z.D, Köylü R, Ergin M, Günaydın Y.K, Özer R, Cander B. Prognostic Value of Red Cell Distribution Width in Patients with Organophosphate Poisoning. JAEM 2015; 14: 65-9 8. Vezzanı G, Socıas S, Bıanco A, Paolı A, Cabertı L, Antadorı L et al. Inflammatory Medıators And Other Bıomarkers In Co-Intoxıcated Patıents After Hyperbarıc Oxygen Therapy (Hbo2). Acta Medica Mediterranea 2016; 32: 189 9. Lippi G, Rastelli G, Meschi T, Borghi L, Cervellin G. Pathophysiology, clinics, diagnosis and treatments of heart involvement in carbon monoxide poisoning. Clin Biochem 2012; 45: 1278-85
  4. Alonso JR, Cardellach F, López S, Casademont J, Miró O. Carbon monoxide specifically inhibits cytochrome c oxidase of human mitochondrial respiratory chain. Pharmacol Toxicol 2003;93:142-6
  5. Kulaksizoglu B, Kulaksizoglu S. Relationship between neutrophil lymphocyte ratio with oxidative stress and psychopathology in patients with schizophrenia. Neuropsychiatr Dis Treat. 2016;12:1999-2005 12. de Jager CP, van Wijk PT, Mathoera RB, de Jongh-Leuvenink J, van der Poll T, Wever PC. Lymphocytopenia and neutrophil-lymphocyte count ratio predict bacteremia better than conventional infection markers in an emergency care unit. Crit Care 2010;14:R192
  6. Ayhan SS, Oztürk S, Erdem A, Ozlü MF, Ozyaşar M, Erdem K et al. Relation of neutrophil/lymphocyte ratio with the presence and severity of coronary artery ectasia. Turk Kardiyol Dern Ars. 2013;41:185–190
  7. Azab B, Jaglall N, Atallah JP, Lamet A, Raja-Surya V, Farah B et al. Neutro