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Journals / Journal of Clinical and Experimental Investigations / 2013 / Cilt: 4 - Sayı: 1

Fluoksetine bağlı, geçici normoprolaktinemik galaktore

Transient normoprolactinemic galactorrhea induced by fluoxetine

Fatih CANAN
Gjergji SINANI
Ünsal AYDINOĞLU
Pages
105–106
Publication Date
2022-10-18
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This report highlightsthe presence of unidentified mechanisms of selectiveserotonin reuptake inhibitor induced galactorrhea.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Hormonal side effects of antidepressants are infrequent.Galactorrhea is rarely reported among antidepressantrelated side effects.
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Key Findings & Data:Antidepressants can directly stimu-late postsynaptic 5- Hydroxytryptamine (5-HT) receptorsin the hypothalamus or indirectly inhibit the tuberoinfun-dibular dopaminergic neurons through 5-HT, which mayincrease prolactin levels and later cause galactorrhea.However, galactorrhea may develop despite normal prolactin levels during antidepressant treatment.
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Conclusion & Impact:This report highlightsthe presence of unidentified mechanisms of selectiveserotonin reuptake inhibitor induced galactorrhea.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Hormonal side effects of antidepressants are infrequent.Galactorrhea is rarely reported among antidepressantrelated side effects. Antidepressants can directly stimu-late postsynaptic 5- Hydroxytryptamine (5-HT) receptorsin the hypothalamus or indirectly inhibit the tuberoinfun-dibular dopaminergic neurons through 5-HT, which mayincrease prolactin levels and later cause galactorrhea.However, galactorrhea may develop despite normal prolactin levels during antidepressant treatment. We presenta case of normoprolactinemic galactorrhea in a woman,related with fluoxetine treatment. This report highlightsthe presence of unidentified mechanisms of selectiveserotonin reuptake inhibitor induced galactorrhea.

Özet

Antidepresanlara bağlı hormonal yan etkiler sık görülmemektedir. Galaktore, antidepresanlara bağlı yan etkilerarasında nadiren bildirilmiştir. Antidepresanlar, hipotalamustaki postsinaptik 5-Hidroksitriptamin (5-HT) reseptörlerini doğrudan uyararak veya tuberoinfindibuler dopaminerjik nöronları 5-HT üzerinden dolaylı olarak inhibe ederek prolaktin seviyelerinde artışa ve sonuçta galaktoreye neden olabilirler. Ancak antidepresan tedavisi sırasında normal prolaktin seviyelerine rağmen galaktore gelişebilir.Bu çalışmada fluoksetin tedavisi ile ilişkili normoprolaktinemik galaktore gelişen bir kadın olgu sunulacaktır. Buolgu sunumu ile selektif serotonin gerialım inhibitörlerine bağlı galaktorenin tanımlanmamış mekanizmalarının varlığı üzerine vurgu yapılacaktır.

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Cite This Article

CANAN, F., SINANI, G., AYDINOĞLU, Ü. (2022). Fluoksetine bağlı, geçici normoprolaktinemik galaktore. Journal of Clinical and Experimental Investigations, Cilt: 4 - Sayı: 1, 105–106. https://ajindex.com/articles/561863

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